A5101963458- Gastrointestinal motility and disorders
- Mitochondrial Function and Pathology
- Inflammatory Bowel Disease
- Gut microbiota and health
- Autophagy in Disease and Therapy
- Renin-Angiotensin System Studies
- Helicobacter pylori-related gastroenterology studies
- Pharmacological Effects of Natural Compounds
- Endoplasmic Reticulum Stress and Disease
- Complementary and Alternative Medicine Studies
- Cardiac Ischemia and Reperfusion
- Protein Hydrolysis and Bioactive Peptides
- MicroRNA in disease regulation
- Hormonal Regulation and Hypertension
- Advanced Glycation End Products research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Immune Response and Inflammation
- Drug Transport and Resistance Mechanisms
- Berberine and alkaloids research
- Eosinophilic Esophagitis
- Gastroesophageal reflux and treatments
- Biomarkers in Disease Mechanisms
- Cardiovascular and Diving-Related Complications
- Connective Tissue Growth Factor Research
- Pathogenesis and Treatment of Hiccups
Changchun University
2025
Guangdong Provincial Hospital of Traditional Chinese Medicine
2022-2024
Innovation Team (China)
2022-2024
Guangzhou University of Chinese Medicine
2019-2024
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2020-2024
University of Electronic Science and Technology of China
2020-2024
Guangdong-Hongkong-Macau Joint Laboratory of Collaborative Innovation for Environmental Quality
2024
Sinopec (China)
2023
Chinese Center For Disease Control and Prevention
2021
Center for Disease Control
2021
ABSTRACT Imbalanced gut microbiota (GM) and abnormal fecal bile acid (BA) are thought to be the key factors for diarrhea-predominant irritable bowel syndrome (IBS-D), but underlying mechanism remains unclear. Herein, we explore influence of GM–BA–Takeda G-protein-coupled receptor 5 (TGR5) axis on IBS-D. Twenty-five IBS-D patients fifteen healthy controls were recruited perform BA-related metabolic metagenomic analyses. Further, microbiota-humanized rat model was established by microbial...
Ulcerative colitis (UC) presents diagnostic and therapeutic difficulties. The primary objective of this study is to identify efficacious biomarkers for diagnosis treatment, as well acquire a deeper understanding the immuneological characteristics associated with disease.
Abstract Parkinson's disease (PD) is a prevalent neurodegenerative disorder with significant negative health and economic implications for individuals, families society. This study utilized an individual‐level time‐stratified case‐crossover design to investigate the relationship between ambient temperatures PD mortality among elderly in China. A combination of conditional logistic regression distributed lag non‐linear model was employed analyze data, burden attributed quantified. The...
Resveratrol displays cardioprotective activity; however, its mechanism of action remains unclear. In the current study, resveratrol-induced myocardial protection from endoplasmic reticulum stress (ERS) was investigated, focusing on roles Zn2+ and mitochondrial permeability transition pore (mPTP). We found, using MTT/LDH kit, that 2-DG-induced ERS significantly decreased H9c2 cell viability. markedly inhibited expression chaperone GRP 78/94 ERS-related apoptosis proteins CHOP, Caspase12, JNK...
QingChang-XiaoPi Decoction (QCXPY), a Chinese herbal prescription, has been employed in the treatment of ulcerative colitis (UC) China. However, its molecular mechanism action UC remains unclear.
Evidence of the advantages Coptidis Rhizoma (CR) for treatment ulcerative colitis (UC) is accumulating. However, research revealing targets and molecular mechanisms CR against UC scarce. In this research, a bioinformatics analysis was performed to carry out physicochemical properties biological activities phytochemicals in analyze binding activities, targets, functions UC. This shows that CR’s key phytochemicals, which are named Coptisine, Berberrubine, Berlambine, Berberine, Epiberberine,...
The brain-gut-microbiota (BGM) axis is known to be essential for diarrhea-predominant irritable bowel syndrome (IBS-D). In order evaluate the effects of IBS-D rat models (the central sensitization model, peripheral model and compound model) on BGM axis, five were induced in Wistar rats with 4% acetic acid (AD, dissolved 0.4 ml AD 9.6 ultrapure water) + wrap restrain stress (WRS), AD, colorectal distention (CRD), WRS, neonatal maternal separation (NMS). Abdominal withdrawal reflex (AWR) scale...
Objective . This study aimed to investigate whether astragaloside IV modulates the mitochondrial permeability transition pore (mPTP) opening through glycogen synthase kinase 3 β (GSK-3 ) in H9c2 cells. Methods cells were exposed for 20 min. GSK-3 (Ser 9 ), Akt 473 and VASP 239 activities determined with western blot. The mPTP was evaluated by measuring membrane potential (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mi...
Aim of the study: To evaluate protective effect and mechanism shenling baizhu powder (SBP) on TNBS-induced colitis. Methods: Rats were given TNBS to establish model colitis subsequently treated with different doses SBP or mesalamine (MES). In addition, expression TLR5/MyD88/NF-κB signaling pathway critical targets intestinal mucosal barrier was detected by immunochemical analysis techniques. Results: significantly ameliorated symptoms in rats reduced secretion pro-inflammatory cytokines....
Soluble receptor for advanced glycation end-products (sRAGE) acts as a decoy to prevent interaction between RAGE and its pro-inflammatory ligands.sRAGE levels have been found decrease in chronic inflammatory diseases, including hypertension.However, few data reported concerning the association serum sRAGE hypertensive left ventricular hypertrophy (LVH).Fasting blood samples were obtained from 209 essential patients, measured using commercially available double-sandwich enzyme-linked...
SUMMARY This cross-sectional study aimed to examine and compare prevalence correlates of whole blood Epstein–Barr virus (EBV) DNA between HIV-positive HIV-negative men who have sex with (MSM). Five hundred four MSM 504 age-matched were recruited from an HIV counseling testing clinic in Shanghai, China November 2014 2015 administered a face-to-face questionnaire interview. Whole EBV was tested by nested polymerase chain reaction assays on EBNA-1 , EBNA-2, LMP-1 genes. The 56·0% (95% CI...
Introduction Solid organ transplant recipients are at high risk for developing severe zoster-associated neuralgia, and the pharmaceutic therapies of pain management these patients with limited function challenging. Intravenous lidocaine infusion showed positive analgesic effects is used neuropathic pain. This case series reports safety effectiveness intravenous in treatment intractable neuralgia solid recipients. Case presentation Five suffering from refractory (numeric rating scale 8–10,...
Background Many clinicians are facing the dilemma about whether they should apply active surveillance (AS) strategy for managing Clinically Node-negative (cN0) PTMC patients in daily clinical practice. This research plans to construct a dynamic nomogram based on network, connected with ultrasound characteristics and data, predict risk of central lymph node metastasis (CLNM) cN0 before surgery. Methods A retrospective analysis 659 who had underwent thyroid surgery compartment neck dissection....
While nitric oxide (NO) induces cardioprotection by targeting the mitochondrial permeability transition pore (mPTP), precise signaling events that mediate action of NO remain unclear. The purpose this study was to test whether against ischemia/reperfusion inhibiting oxidative stress through zinc and Src tyrosine kinase. donor S-nitroso-N-acetyl penicillamine (SNAP) given before onset ischemia reduced cell death in rat cardiomyocytes subjected simulated ischemia/reperfusion, abolished...
Abstract Background: Failed intubation and ventilation during cesarean deliveries are important causes of anesthetic-related maternal mortality. Due to the physiological changes in airway anatomy, parturient had higher incidences difficult than non-obstetric population. Accurate assessment is first step most management. However, common clinical screening tests, shown low sensitivity specificity with a limited predictive value. Ultrasound quick, noninvasive, inexpensive tool, advancement...
Abstract Background Diarrhea-predominant irritable bowel syndrome (IBS-D) is a common chronic digestive disease. Recent observational studies have reported that the Chinese herbal formula Huoxiang Zhengqi (HXZQ) can relieve IBS-D symptoms, but no high-level evidence presented. Therefore, we want to evaluate efficacy and safety of HXZQ for patients. Methods This double-blind, randomized, placebo-controlled trial. The 212 eligible patients with will be randomly assigned receive either oral...
<i>Objective:</i> To study the antihypertensive effects of angiotensin-converting enzyme (ACE)-inhibitory peptide LAP on blood pressure in spontaneously hypertensive rats (SHRs). <i>Methods:</i> A cohort 12-week-old SHRs was randomly divided into 2 distinct groups, and ACE-inhibitory (experimental group) or physiological saline (controls) were administered. Caudal arterial then measured at specific time points (0, 4, 8 12 weeks). <i>Results:</i> Systolic...