A5086437407- HIV/AIDS Research and Interventions
- HIV-related health complications and treatments
- HIV, Drug Use, Sexual Risk
- HIV Research and Treatment
- Sex work and related issues
- Adolescent Sexual and Reproductive Health
- HIV/AIDS drug development and treatment
- Radiomics and Machine Learning in Medical Imaging
- Cardiovascular Disease and Adiposity
- MRI in cancer diagnosis
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Viral Infections and Immunology Research
- Viral-associated cancers and disorders
- Atherosclerosis and Cardiovascular Diseases
- Tryptophan and brain disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- RNA and protein synthesis mechanisms
- Medical Imaging Techniques and Applications
- Hepatitis B Virus Studies
- Cervical Cancer and HPV Research
- Immune cells in cancer
- Sleep and related disorders
- Substance Abuse Treatment and Outcomes
- Genital Health and Disease
Fudan University
2016-2025
Changjiang Water Resources Commission
2025
Wuhan University
2025
Renmin Hospital of Wuhan University
2025
Sir Run Run Shaw Hospital
2018-2025
Zhejiang University
2018-2025
Kunming Medical University
2022-2024
Bengbu Medical College
2024
Anhui Agricultural University
2023-2024
Sino Biological (China)
2024
<p indent=0mm>The black soil region in northeastern China is one of the most important grain production areas country, and plays a key role food security. Large lands have been brought into cultivation last <sc>100 years.</sc> Because these lesser slope gradients compared to those loess plateau other regions China, erosion has ignored this area for long time. Few conservation practices implemented. Serious problems due lengths identified based on recent research observations study area. The...
Streptococcus pneumoniae causes bacterial pneumonia with high mortality and morbidity. The emergency of multidrug-resistant bacteria threatens the treatment disease. Leucyl-tRNA synthetase (LeuRS) plays an essential role in cellular translation is attractive drug target for antimicrobial development. Here we report compound ZCL039, a benzoxaborole-based derivative AN2690, as potent anti-pneumococcal agent that inhibits S. LeuRS (SpLeuRS) activity. We show using kinetic, biochemical analyses...
Little is known about the acceptance and actual uptake of pre-exposure prophylaxis (PrEP) associated factors in men who have sex with (MSM) China. This study baseline survey an intervention designed to evaluate effectiveness tenofovirdisoproxil fumarate (TDF) on a daily use for human immunodeficiency virus (HIV) prevention among MSM Shanghai, From October 2012 December 2013, total 1,033 Shanghai were recruited by local district Centers Disease Control Prevention (CDC) community-based...
Background Although HIV treatment as prevention (TasP) via early antiretroviral therapy (ART) has proven to reduce transmissions among HIV-serodiscordant couples, its full implementation in developing countries remains a challenge. In this study, we determine whether China's current program prevents new infections discordant couples rural China. Methods A prospective, longitudinal cohort study was conducted from June 2009 March 2011, Yunnan. total of 1,618 HIV-discordant were eligible, 1,101...
Abstract Background Etrasimod (ETR) is an oral, once daily (qd), selective sphingosine 1-phosphate (S1P)1,4,5 receptor modulator for the treatment of moderately to severely active ulcerative colitis (UC). ES101002 was a registrational Phase (Ph) 3 study evaluating efficacy and safety ETR in Asian patients (pts) with UC (NCT04176588). has shown significant benefit vs placebo (PBO) as induction maintenance therapy pts UC, including 12-week (wk) period (IP) ES101002.1–4 Here, we report results...
Purpose: The growth and survival of multiple myeloma (MM) cells depend heavily on bone marrow microenvironment, where inflammation emerges as a significant feature is commonly associated with unfavorable prognosis in MM. Our previous study other published studies have shown that MM patients higher neutrophil-to-lymphocyte ratio (NLR) or interleukin (IL)-10 (IL-10), lower lymphocyte-to-monocyte (LMR) platelet-to-lymphocyte (PLR) frequently inferior overall (OS) independent current risk-...
Alveolar macrophages (AMs) are crucial for lung homeostasis, and their dysfunction causes uncontrolled fibrotic responses pulmonary disorders. Protein phosphatases control multiple cellular events. However, whether nuclear cooperate with histone modifiers to affect fibrosis progress remains obscure. Here, we identified pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) as a key protective factor fibrosis. Transcriptomics epigenomics data confirmed that PHLPP1...
Objective: To investigate the sero-conversion rate of HIV antibody and influencing factors in cross-border couples Dehong Dai Jingpo Autonomous Prefecture(Dehong). Methods: A cohort design was used to recruit HIV-negative people 2017. Follow-up conducted 2023, questionnaire survey test were carried out calculate antibody. Univariate multivariate logistic regression models analyze influence for infections. Results: total 36 278 persons included 2017 baseline survey, whom 22 438 (61.9%) tested...
Abstract Conventional methods of measuring water discharge and suspended sediment concentration (e.g., sampling moving acoustic Doppler current profiler [ADCP]) present challenges in large tidal rivers due to temporal spatial constraints. This study introduces a novel approach monitor (SSD) rivers. Total SSD exhibit notable variability the river–tidal interactions; understanding this its causes is essential for effective river management. From June November 2023, field was conducted at...
Objectives: To examine HIV/AIDS-related knowledge, attitudes and behaviours among 'money boys' general male migrants in Shanghai, China. Design: A quantitative cross-sectional design with self-administered paper-and-pencil instruments was used. Methods: total of 239 money boys were enrolled using community popular opinion leader respondent-driven sampling methods, 100 through venue-based sampling. Results: Compared to migrants, significantly younger, better educated, more likely be single,...
Abstract Men having sex with men (MSM) now account for 7% of all HIV/AIDS cases in China and there is growing awareness that internal rural-to-urban migration might shift the HIV epidemic within by broadening social sexual mixing. About 70% infections are among rural residents, whom 80% males 60% aged 16–29. This young, male, migrant population has been identified as 'tipping point' AIDS China. A subgroup these migrants 'money boy' population, i.e. those who engage same-sex transactional...
Methadone maintenance treatment (MMT) was introduced to China in 2004 reduce the harm of injecting drug users (IDUs). However, little is known about continued use, especially methamphetamine (MAMP), among MMT patients.A survey conducted patients attending five major clinics Dehong Prefecture 2014 investigate heroin and MAMP use their associated risk factors. Participants were administered with face-to-face interviews, urine tests for morphine MAMP.A total 2,121 eligible participated study....
This study aimed to investigate the prevalence of abdominal obesity and its association with health-related quality life (HRQOL) in a randomly selected Chinese sample. A population-based sample 3,600 residents aged 18–80 years was from 5 cities. Demographic information, waist hip circumference measurements were obtained. The Mandarin version Short Form 36 Health Survey questionnaire (SF-36) used assess HRQOL. Waist (WC) waist-to-hip ratio (WHR) as measures obesity, HRQOL analysed. Among...
Epigenetic regulation of inflammatory macrophages governs inflammation initiation and resolution in the pathogenesis rheumatoid arthritis (RA). Nevertheless, mechanisms underlying macrophage-mediated injuries remain largely obscure. Here, we found that increased expression lysine acetyltransferase 2A (KAT2A) synovial tissues was closely correlated with joint immunopathology both RA patients experimental mice. Administration MB-3, KAT2A-specific chemical inhibitor, significantly ameliorated...