A5100770222- Shoulder Injury and Treatment
- Renal Diseases and Glomerulopathies
- Tendon Structure and Treatment
- Sports injuries and prevention
- Intraperitoneal and Appendiceal Malignancies
- Calcium signaling and nucleotide metabolism
- Epigenetics and DNA Methylation
- Gastrointestinal motility and disorders
- Poisoning and overdose treatments
- IgG4-Related and Inflammatory Diseases
- Myofascial pain diagnosis and treatment
- BRCA gene mutations in cancer
- Electrospun Nanofibers in Biomedical Applications
- Orthopaedic implants and arthroplasty
- Adipokines, Inflammation, and Metabolic Diseases
- Anesthesia and Sedative Agents
- Genetic Associations and Epidemiology
- Diabetes Treatment and Management
- Abdominal vascular conditions and treatments
- Intestinal Malrotation and Obstruction Disorders
- Atherosclerosis and Cardiovascular Diseases
- Lung Cancer Treatments and Mutations
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Congenital gastrointestinal and neural anomalies
- Sports Dynamics and Biomechanics
Nanjing Medical University
2014-2025
Jiangsu Province Hospital
2025
Shenzhen Second People's Hospital
2014-2025
Shenzhen University
2025
Wenzhou Medical University
2015-2024
Shaoxing People's Hospital
2024
Zhejiang Taizhou Hospital
2023
Zhejiang University
2014-2021
Children's Hospital of Zhejiang University
2018-2021
Second Affiliated Hospital of Zhejiang University
2020
Treatment of lupus nephritis (LN) remains challenging.To assess the efficacy and safety a multitarget therapy consisting tacrolimus, mycophenolate mofetil, steroid compared with intravenous cyclophosphamide as induction for LN.24-week randomized, open-label, multicenter study. (ClinicalTrials.gov: NCT00876616).26 renal centers in China.Adults (aged 18 to 65 years) biopsy-proven LN.Tacrolimus, 4 mg/d, 1.0 g/d, versus starting dose 0.75 (adjusted 0.5 1.0) g/m2 body surface area every weeks 6...
Abstract Bisphenol A (BPA), a typical environmental endocrine-disrupting chemical, induces epigenetic inheritance. Whether histone acetylation plays role in these effects of BPA is largely unknown. Here, we investigated male rats after long-term exposure to ‘safe’ dose BPA. Twenty adult received either (50 μg/kg·bw/day) or vehicle diet for 35 weeks. Decreased protein lysine-acetylation levels at approximately ~17 kDa and ~25 kDa, as well decreased H3K9, H3K27 H4K12, were detected by Western...
Abstract Peripheral nerve injuries are one of the most common types traumatic damage to nervous system. Treatment peripheral aims promote axon regrowth by imitating and improving microenvironment for sciatic regeneration. In this study, regeneration efficiency behavior nerves compared under three treatment strategies: 1) transplantation Schwann cell progenitors induced from purified neural crest stem cells; 2) implantation a multiscale scaffold based on high‐resolution 3D printing; 3) bionic...
Defective lipid metabolism is associated with increased risk of various chronic diseases, such as obesity, cardiovascular and diabetes. Resveratrol (RSV), a natural polyphenol, has been shown the potential ameliorating disregulations metabolism. The objective this study was to investigate effects feed intake RSV on in zebrafish (Danio rerio). adult males were randomly allocated 6 groups: control (Con, 8 mg cysts/fish/day), 20 μmol/L (Con+RSV), calorie restriction (CR, 5 (CR+RSV), overfeed...
Abstract Background Etrasimod (ETR) is an oral, once daily (qd), selective sphingosine 1-phosphate (S1P)1,4,5 receptor modulator for the treatment of moderately to severely active ulcerative colitis (UC). ES101002 was a registrational Phase (Ph) 3 study evaluating efficacy and safety ETR in Asian patients (pts) with UC (NCT04176588). has shown significant benefit vs placebo (PBO) as induction maintenance therapy pts UC, including 12-week (wk) period (IP) ES101002.1–4 Here, we report results...
Background Blood transfusion is usually required for cirrhotic patients with bleeding which related to high risk of mortality. Identifying at and needing blood transfusions would benefit these patients, yet this remains an unmet need. Objectives This study aims enhance management cirrhosis by developing a predictive model assess the transfusion. Methods We enrolled cohort 711 diagnosed The First Affiliated Hospital Nanjing Medical University divided into training set ( n = 537) validation...
The relationship between the triglyceride glucose (TyG) values and development of diabetes in non-alcoholic fatty liver disease (NAFLD) patients is not yet well researched. This study aims to examine how baseline TyG levels correlate with incidence new-onset this specific cohort. cohort included 2,506 normoglycemic Japanese adults NAFLD who underwent routine health check-ups at Murakami Memorial Hospital 2004 2015. Several statistical approaches, including restricted cubic splines...
Abstract Background The metabolic score for insulin resistance (MetS-IR) has become a valid indicator to evaluate resistance. Our investigation sought gender differences in the correlation between MetS-IR and reversion from prediabetes normoglycemic status. Methods This retrospective research, carried out 32 areas across 11 cities with several centers China, encompassed 15,423 participants prediabetes. We employed Cox proportional hazards regression model examine link also applied cubic...
Aim . To evaluate the predictive value of RRM1, ERCCl, and BRCA1 expression in Chinese NSCLC patients treated with gemcitabine cisplatin. Methods Real-time fluorescent quantitative PCR was used to determine ERCC1, mRNA levels peripheral blood late-stage patients. The relationship between tumor tissues analyzed further. Results In terms susceptibility chemotherapy, response rate low-RRM1-expression group significantly greater than high-expression (52.9% versus 5.9%,<mml:math...
BackgroundDifferent arthroscopic techniques exist for managing the extensor carpi radials brevis (ECRB) when treating refractory lateral epicondylitis. The purpose of this study is to compare outcomes a standard débridement with ECRB tendon release an tenotomy distal its insertion without using retrospective cohort design.MethodsThis included patients underwent treatment epicondylitis during 2 different time periods: 2016-2019 (débridement) and 2019-2021 (modified débridement). Patients were...
Cell therapy has great promise for treating gastrointestinal motility disorders caused by intestinal nervous system (ENS) diseases. However, appropriate sources, other than enteric neural stem cells and human embryonic cells, are seldom reported. Here, we show that progenitors derived from the dorsal root ganglion (DRG) of EGFP mice survived, differentiated into neurons glia migrated widely site injection, established neuron-muscle connections following transplantation distal colon postnatal...
It has long been hypothesized that personality plays a causative role in incidence and outcome of breast cancer (BC), but epidemiological evidence association between BC is inconsistent.We used two-sample Mendelian randomization analysis to estimate the impact on risk survival BC. In total, 109 single nucleotide polymorphisms (SNPs) were utilized as instruments neuroticism from large-scale Genome-Wide Association Studies (GWAS), five SNPs extraversion Genetic Personality Consortium 23andMe....
We propose schemes capable of measuring an arbitrary set commutative logical Pauli operators in time independent the number operators. The only condition is commutativity, a fundamental requirement for simultaneous measurements quantum mechanics. Quantum low-density parity check (LDPC) codes show great promise realising fault-tolerant computing. They are particularly significant early technologies as they can encode many qubits using relatively few physical qubits. By achieving operators,...
ObjectivesTo investigate that the treatment of hemofiltration combine with HA hemoadsorption to improve immune function in HLA-DR low expression sepsis patients.Methods 60 patients HLA -DR < 30% was selected, and divided them randomly into experimental group control group, each has 30 cases, they were treated standard operating procedures, on basis that, increases 1-3 days, CVVH mode, former dilution volume is 4L/h, hemofilter HF2000 series blood adsorber -330H.On 0, 3, 5, 7 days treatment,...