A5089862084- Tryptophan and brain disorders
- Herpesvirus Infections and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Toxoplasma gondii Research Studies
- Cancer-related molecular mechanisms research
- Parasites and Host Interactions
- Transgenic Plants and Applications
- Hepatitis C virus research
- Parasitic infections in humans and animals
- Animal Virus Infections Studies
- Hepatitis B Virus Studies
- Photosynthetic Processes and Mechanisms
- Liver Disease Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Viral Infections and Immunology Research
- Parasitic Infections and Diagnostics
- Bacteriophages and microbial interactions
- Gut microbiota and health
- HIV Research and Treatment
- Plant tissue culture and regeneration
- Antioxidant Activity and Oxidative Stress
- RNA modifications and cancer
- MicroRNA in disease regulation
- Acute Myocardial Infarction Research
Xuzhou Medical College
2016-2025
Wenzhou Medical University
2012-2025
Shuguang Hospital
2013-2025
Shanghai University of Traditional Chinese Medicine
2013-2025
Shanghai University
2023-2025
Taizhou University
2025
Peking Union Medical College Hospital
2024-2025
Southern University of Science and Technology
2025
National Clinical Research Center for Digestive Diseases
2025
Peking University
2025
"Western" style dietary patterns are characterized by a high proportion of highly processed foods rich in fat and low fiber. This diet pattern is associated with myriad metabolic dysfunctions, including neuroinflammation cognitive impairment. β-glucan, the major soluble fiber oat barley grains, fermented lower gastrointestinal tract, potentially impacting microbial ecosystem thus may improve elements cognition brain function via gut-brain axis. The present study aimed to evaluate effect...
Postoperative cognitive decline (POCD) is a recognized clinical phenomenon characterized by impairments in patients following anesthesia and surgery, yet its underlying mechanism remains unclear. Brain-derived neurotrophic factor (BDNF) plays an important role neuronal plasticity, learning, memory via activation of TrkB-full length (TrkB-FL) receptors. It has been reported that abnormal truncation TrkB mediated calpain results dysregulation BDNF/TrkB signaling associated with several...
Abstract Background Cognitive impairment, an increasing mental health issue, is a core feature of the aging brain and neurodegenerative diseases. Industrialized nations especially, have experienced marked decrease in dietary fiber intake, but potential mechanism linking low intake cognitive impairment poorly understood. Emerging research reported that diversity gut microbiota Western populations significantly reduced. However, it unknown whether fiber-deficient diet (which alters microbiota)...
Obesity is a risk factor for neurodegenerative disease associated with cognitive dysfunction, including Alzheimer's disease. Low-grade inflammation common in obesity, but the mechanism between and impairment obesity unclear. Accumulative evidence shows that quinolinic acid (QA), neuroinflammatory neurotoxin, involved pathogenesis of processes. We investigated role QA obesity-induced beneficial effect butyrate counteracting impairments cognition, neural morphology, signaling. show human there...
Gut homeostasis, including intestinal immunity and microbiome, is essential for cognitive function via the gut-brain axis. This axis altered in high-fat diet (HFD)-induced impairment closely associated with neurodegenerative diseases. Dimethyl itaconate (DI) an derivative has recently attracted extensive interest due to its anti-inflammatory effect. study investigated whether intraperitoneal administration of DI improves prevents deficits HF diet-fed mice.DI effectively attenuated...
Inflammation and reactive oxygen species (ROS) play important roles in the pathogenesis of atherosclerosis. Resveratrol has been shown to possess anti-inflammatory antioxidative stress activities, but underlying mechanisms are not fully understood. In present study, we investigated molecular basis associated with protective effects resveratrol on tumor necrosis factor-alpha (TNF-α)-induced injury human umbilical endothelial cells (HUVECs) using a variety approaches including cell viability...
A growing body of evidence has indicated that long non-coding RNAs (lncRNAs) serve as competing endogenous (ceRNAs) during oncogenesis. In this study, the qRT-PCR results lncRNA PVT1 is overexpressed in osteosarcoma and decreased survival rate patients. MTT clonal colony formation assays were used to detect effect on proliferation, flow cytometry was performed assess apoptosis cell cycle. Transwell assay analyze migration invasion. The revealed silencing by siRNA inhibited invasion promoted...
Pain and depression are frequently co-existent in clinical practice, yet the underlying mechanisms remain largely to be determined. Microglia activation subsequent pro-inflammatory responses play a crucial role development of neuropathic pain depression. The process microglia polarization M1 or anti-inflammatory M2 phenotypes often occurs during neuroinflammation. However, it remains unclear whether M1/M2 is involved induced by spared nerve injury (SNI). In present study, mechanical...
Abstract Background Postoperative cognitive dysfunction (POCD) is associated with worsened prognosis especially in aged population. Clinical and animal studies suggested that electroacupuncture (EA) could improve POCD. However, the underlying mechanisms EA’s regulatory role of inflammasomes remain unclear. Methods The model POCD was established by partial hepatectomy surgery 18‐month mice or without postoperative EA treatment to Baihui acupoint (GV20) for 7 days. Cognitive functions were...
Avian leukosis virus subgroup J (ALV-J) was first isolated from meat-type chickens in 1988. No field cases of ALV-J infection or tumors layer were observed worldwide until 2004. However, flocks China have experienced outbreaks this recent years. The molecular epidemiology strains investigated. env genes 77.8% (21/27) the isolates with a high degree genetic variation significantly different prototype strain (HPRS-103) and American Chinese (designated broiler isolates). A total 205 nucleotides...
Streptococcus pneumoniae causes bacterial pneumonia with high mortality and morbidity. The emergency of multidrug-resistant bacteria threatens the treatment disease. Leucyl-tRNA synthetase (LeuRS) plays an essential role in cellular translation is attractive drug target for antimicrobial development. Here we report compound ZCL039, a benzoxaborole-based derivative AN2690, as potent anti-pneumococcal agent that inhibits S. LeuRS (SpLeuRS) activity. We show using kinetic, biochemical analyses...
Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disease, which affects more and people. But there still no effective treatment for preventing or reversing the progression of disease. Soluble amyloid-beta (A β ) oligomers, also known as A -derived diffusible ligands (ADDLs) play an important role in AD. Synaptic activity cognition critically depend on function glutamate receptors. Targeting N -methyl- D -aspartic acid (NMDA) receptors trafficking its regulation new...
Provide an evolutionary and empirical molecular genetic foundation of the Sus gene family in tobacco will be beneficial for further investigations functions Sucrose synthase (Sus) has been well characterized as key enzyme participating sucrose metabolism, encoding different isozymes cloned several plant species. However, scant information about this is available to date tobacco. Here, we identified 14, 6, 7 genes genomes Nicotiana tabacum, N. sylvestris tomentosiformis, respectively. These...
Th17 cells and interleukin-17 (IL-17) have been found to play an important role in the pathology of multiple sclerosis (MS) its animal model, experimental autoimmune encephalomyelitis (EAE). Response IL-17, reactive astrocytes accompany with immune infiltration axonal damage MS/EAE. However, regulatory mechanism IL-17-activated inflammation EAE process still remain largely unknown. Here, we elucidated that miR-409-3p miR-1896, as co-upregulated microRNAs activated mice, targeted suppressor...
Abstract Although pain is frequently accompanied with depression, little known about the risk factors contributing to individual differences comorbidity of and depression. In this study, we examined whether cytokines brain-derived neurotrophic factor (BDNF) might contribute in development neuropathic pain-induced Rats were randomly subjected spared nerved ligation (SNI) or sham surgery. The SNI rats divided into two groups by data from depression-related behavioral tests. depression-like...
Abstract Background Long-term high fat (HF) diet intake can cause neuroinflammation and cognitive decline through the gut-brain axis. (1, 3)/(1, 6)-β-glucan, an edible polysaccharide isolated from medical mushroom, Lentinula edodes ( L. ), has potential to remodel gut microbiota. However, effects of derived β-glucan against HF diet-induced remain unknown. This study aimed evaluate neuroprotective effect mechanism dietary L supplementation obesity-associated in mice fed by a diet. Methods...
Tobacco plants (Nicotiana tabacum L.) exhibit considerable potential for phytoremediation of soil cadmium (Cd) pollutants, owing to their substantial biomass and efficient metal accumulation capabilities. The reduction Cd in tobacco holds promise minimizing intake individuals exposed cigar smoking. NRAMP transporters are pivotal the processes resistance plants; however, limited research has explored functions NRAMPs plants. In this investigation, we focused on NtNRAMP6c, one three homologs...
Background Chronic infection with the neurotropic parasite Toxoplasma gondii (T. gondii) can cause anxiety and gut microbiota dysbiosis in hosts. However, potential role of induced by remains unclear.
Background Cystic echinococcosis is a global parasitic disease caused by infection with Echinococcus granulosus larvae potentially life-threatening complications in humans. To date, the status of immune cells believed to be associated pathogenicity E. has not been demonstrated clearly. Methodology/Principal Findings In this study, we developed multiplex flow cytometry assay investigate systemic innate and adaptive immunity at 30, 180, 360 days post-infection (dpi) mice infected granulousus....