A5100321393- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- RNA Research and Splicing
- MicroRNA in disease regulation
- S100 Proteins and Annexins
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Cell death mechanisms and regulation
- Immune Cell Function and Interaction
- Pharmacology and Obesity Treatment
- Fuel Cells and Related Materials
- Urinary Bladder and Prostate Research
- interferon and immune responses
- Hydraulic and Pneumatic Systems
- RNA and protein synthesis mechanisms
- T-cell and B-cell Immunology
- Peptidase Inhibition and Analysis
- Amoebic Infections and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Pregnancy and preeclampsia studies
- Hormonal and reproductive studies
- Cell Adhesion Molecules Research
Chengdu University of Traditional Chinese Medicine
2023
Second Military Medical University
2008-2021
Baotou Central Hospital
2020
Changhai Hospital
2017-2019
Second Hospital of Hebei Medical University
2019
Hebei Medical University
2019
Eastern Hepatobiliary Surgery Hospital
2016
Shanghai Changzheng Hospital
2014
Third Affiliated Hospital of Guangzhou Medical University
2012
Guangzhou Medical University
2012
N 6 ‐Methyladenosine (m A) modification has been implicated in many biological processes. However, its role cancer not well studied. Here, we demonstrate that m A modifications are decreased hepatocellular carcinoma, especially metastatic and methyltransferase‐like 14 (METTL14) is the main factor involved aberrant modification. Moreover, METTL14 down‐regulation acts as an adverse prognosis for recurrence‐free survival of carcinoma significantly associated with tumor metastasis vitro vivo ....
In recent years, long noncoding RNAs (lncRNAs) have been shown to critical regulatory roles in cancer biology. However, the contributions of lncRNAs hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) remain largely unknown. Differentially expressed between HBV-related HCC and paired peritumoral tissues were identified by microarray validated using quantitative real-time polymerase chain reaction. Liver samples from patients with analyzed for levels a specific differentially...
Many protein-coding oncofetal genes are highly expressed in murine and human fetal liver silenced adult liver. The protein products of these hepatic have been used as clinical markers for the recurrence hepatocellular carcinoma (HCC) therapeutic targets HCC. Herein we examined expression profiles long noncoding RNAs (lncRNAs) found mice. lncRNAs were identified; one these, lncRNA-mPvt1, is an RNA that was to promote cell proliferation, cycling, stem cell-like properties cells. Interestingly,...
The molecular mechanisms driving hepatocellular carcinoma (HCC) remain largely unclear. As one of the major epitranscriptomic modifications, N6-methyladenosine (m6A) plays key roles in HCC. aim this study was to investigate expression, roles, and action RNA methyltransferase methyltransferase-like protein 16 (METTL16) HCC.The expression METTL16 RAB11B-AS1 determined by RT-qPCR. regulation investigated immunoprecipitation (RIP), methylated RIP (MeRIP), stability assays. In vitro vivo gain-...
In recent years, long noncoding RNAs (lncRNAs) have been investigated as a new class of regulators biological function. A study reported that lncRNAs control cell proliferation in hepatocellular carcinoma (HCC). However, the role liver regeneration and overall mechanisms remain largely unknown. To address this issue, we carried out genome-wide lncRNA microarray analysis during mice after 2/3 partial hepatectomy (PH) at various timepoints. The results revealed differential expression subset...
Abstract As an important epigenetic mechanism, histone acetylation modulates the transcription of many genes and plays roles in hepatocellular carcinoma (HCC). Aberrations have been observed HCC, but factors that contribute to aberrations not fully elucidated. MicroRNAs (miRNAs), which are noncoding RNAs regulate gene expression, involved mechanisms. In this study, we determined miR-200a level H3 at its promoter were reduced human HCC tissues comparison with adjacent noncancerous hepatic...
Systemic analyses using large-scale genomic profiles have successfully identified cancer-driving somatic copy number variations (SCNVs) loci. However, functions of vast focal SCNVs in "protein-coding gene desert" regions are largely unknown. The integrative analysis long noncoding RNA (lncRNA) expression with hepatocellular carcinoma (HCC) led us to identify the recurrent deletion lncRNA-PRAL (p53 regulation-associated lncRNA) on chromosome 17p13.1, whose alterations were significantly...
Downregulation of Aldolase B (ALDOB) has been reported in hepatocellular carcinoma. However, its clinical significance and role pathogenesis HCC remain largely unknown.We analyzed the expression ALDOB features a large cohort 313 patients using tissue microarray immunohistochemistry. Moreover, function stably overexpressed cells was explored vitro vivo. Gene analysis performed on ALDOB-overexpressing SMMC7721 to elucidate mechanism action.ALDOB downregulation significantly correlated with...
Dysfunctions of epithelial–mesenchymal transition (EMT)-regulated cell migration and invasion have been involved in the pathogenesis pre-eclampsia (PE). However, role circRNAs EMT PE has not widely investigated. In this study, we identified that circTNRC18 was upregulated placentas compared with normal pregnancy placentas. Moreover, negatively regulated trophoblast EMT. Overexpression reduced while depletion enhanced Mechanistically, sponged miR-762 contributed to inhibit activity elevated...
Accumulating evidence suggests that circular RNAs (circRNAs) play important roles in various physiological and pathological processes. In the present study, we explored role of circRNA PVT1 hepatocellular carcinoma (HCC). qRT-PCR was performed to detect relative expression circPVT1 HCC tissues cell lines. The oncogenic were evaluated by counting kit-8 (CCK-8) assay, ethynyl deoxyuridine (EdU) incorporation assays, transwell flow cytometry vivo xenograft growth. Furthermore, bioinformatics,...
ABSTRACT Pulmonary microvascular leakage is one of the characteristics blood–air barrier dysfunction in septic acute lung injury/acute respiratory distress syndrome (ALI/ARDS). Fibroblast growth factor-inducible 14 (Fn14) exerts diverse functions under certain circumstances. However, role Fn14 on integrity pulmonary endothelial cells (PMVECs) during sepsis remains unknown. Septic ALI was induced via cecal ligation and puncture (CLP). expression PMVECs measured 24 h after surgery. The effects...
Abstract We previously reported cloning of the Taenia solium annexin B1 gene from a metacestode cDNA expression library and demonstrated that it acts as protective antigen for effective vaccine development against cysticercosis. In present study we produced recombinant antiserum protein to investigate its structural functional properties. Western blotting fractions indicated T. B1, similar vertebrate annexins, associates with acid phospholipids in presence Ca 2+ . This property was confirmed...
Saw palmetto extract (SPE) has been widely used as a therapeutic remedy for urinary dysfunction in western countries. Furthermore, an herb drug, it can be alternative therapy benign prostatic hyperplasia (BPH) due to its safety and minimum adverse effects. Reportedly, SPE improves the symptoms, which mainly depend on anti-androgenic effects autonomic receptors lower tract. However, mechanisms of action responsible roles have not fully elucidated. Relevant studies indicate that some positive...
<p>Screening of YTHDF1 target genes in gastric cancer.</p>