A5067013860- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA Research and Splicing
- Cancer-related gene regulation
- Hepatitis B Virus Studies
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- Alzheimer's disease research and treatments
- RNA Interference and Gene Delivery
- Connective tissue disorders research
- Liver Disease Diagnosis and Treatment
- Scoliosis diagnosis and treatment
- Autophagy in Disease and Therapy
- Renal and related cancers
- Hepatocellular Carcinoma Treatment and Prognosis
- Endoplasmic Reticulum Stress and Disease
- Ferroptosis and cancer prognosis
- Genetic factors in colorectal cancer
- S100 Proteins and Annexins
- Cancer, Lipids, and Metabolism
- Cancer Mechanisms and Therapy
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver physiology and pathology
Second Military Medical University
2015-2024
Xiaomi (China)
2024
Ministry of Education of the People's Republic of China
2023-2024
Shanghai Changzheng Hospital
2019
Kaohsiung Medical University
2017
Kaohsiung Medical University Chung-Ho Memorial Hospital
2017
Eastern Hepatobiliary Surgery Hospital
2016
University of California, Los Angeles
2000-2012
VA Greater Los Angeles Healthcare System
2000-2012
Fudan University Shanghai Cancer Center
2009
The brain in Alzheimer's disease (AD) shows a chronic inflammatory response characterized by activated glial cells and increased expression of cytokines complement factors surrounding amyloid deposits. Several epidemiological studies have demonstrated reduced risk for AD patients using nonsteroidal anti-inflammatory drugs (NSAIDs), prompting further inquiries about how NSAIDs might influence the development pathology inflammation CNS. We tested impact orally administered ibuprofen, most...
N 6 ‐Methyladenosine (m A) modification has been implicated in many biological processes. However, its role cancer not well studied. Here, we demonstrate that m A modifications are decreased hepatocellular carcinoma, especially metastatic and methyltransferase‐like 14 (METTL14) is the main factor involved aberrant modification. Moreover, METTL14 down‐regulation acts as an adverse prognosis for recurrence‐free survival of carcinoma significantly associated with tumor metastasis vitro vivo ....
In recent years, long noncoding RNAs (lncRNAs) have been shown to critical regulatory roles in cancer biology. However, the contributions of lncRNAs hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) remain largely unknown. Differentially expressed between HBV-related HCC and paired peritumoral tissues were identified by microarray validated using quantitative real-time polymerase chain reaction. Liver samples from patients with analyzed for levels a specific differentially...
Many protein-coding oncofetal genes are highly expressed in murine and human fetal liver silenced adult liver. The protein products of these hepatic have been used as clinical markers for the recurrence hepatocellular carcinoma (HCC) therapeutic targets HCC. Herein we examined expression profiles long noncoding RNAs (lncRNAs) found mice. lncRNAs were identified; one these, lncRNA-mPvt1, is an RNA that was to promote cell proliferation, cycling, stem cell-like properties cells. Interestingly,...
Survival of patients with hepatocellular carcinoma (HCC) remains poor, which is largely attributed to active angiogenesis. However, the mechanisms underlying angiogenesis in HCC remain be discovered. In this study, we found that long noncoding RNA associated microvascular invasion (lncRNA MVIH) HCC) was generally overexpressed HCC. a cohort 215 patients, overexpression MVIH frequent (P = 0.016) and higher tumor node metastasis stage 0.009) as well decreased recurrence-free survival (RFS) <...
Tumor cells with stemness (stem-cell) features contribute to initiation and progression of hepatocellular carcinoma (HCC), but involvement long noncoding RNAs (lncRNAs) remains largely unclear. Genome-wide analyses were applied identify tumor-associated lncRNA-DANCR. DANCR expression level prognostic values assayed in two HCC cohorts (China Korea, n = 135 223). Artificial modulation (down- overexpression) was done explore the role tumorigenesis colonization, tumor-bearing mice used determine...
Although numerous long non-coding RNAs (lncRNAs) have been identified in mammals, many of their biological roles remain to be characterized. Early reports suggest that H19 contributes carcinogenesis, including hepatocellular carcinoma (HCC). Examination the Oncomine resource showed most HCC cases express at a level is comparable with liver, tendency toward lower expression. This consistent our previous microarray data and indicates more complicated role needs In this study, expression was...
With the development of RNA-seq technology, tens thousands circular RNAs (circRNAs), a novel class RNAs, have been identified. However, little is known about circRNA formation and biogenesis in hepatocellular carcinoma (HCC).We performed ribosomal-depleted profiling HCC para-carcinoma tissues analyzed expression hotspot derived from 3'UTR stearoyl-CoA desaturase (SCD) gene, termed SCD-circRNA 2.It was significantly upregulated correlated with poor patient prognosis. Moreover, we observed...
In recent years, long noncoding RNAs (lncRNAs) have been investigated as a new class of regulators biological function. A study reported that lncRNAs control cell proliferation in hepatocellular carcinoma (HCC). However, the role liver regeneration and overall mechanisms remain largely unknown. To address this issue, we carried out genome-wide lncRNA microarray analysis during mice after 2/3 partial hepatectomy (PH) at various timepoints. The results revealed differential expression subset...
Abstract As an important epigenetic mechanism, histone acetylation modulates the transcription of many genes and plays roles in hepatocellular carcinoma (HCC). Aberrations have been observed HCC, but factors that contribute to aberrations not fully elucidated. MicroRNAs (miRNAs), which are noncoding RNAs regulate gene expression, involved mechanisms. In this study, we determined miR-200a level H3 at its promoter were reduced human HCC tissues comparison with adjacent noncancerous hepatic...
miR-17-5p is overexpressed in hepatocellular carcinoma (HCC), but the specific regulatory mechanisms of HCC remain unknown. We investigated molecular basis as an oncogene human cell lines. Our vivo and vitro data indicate that up-regulates migration proliferation cells. Interestingly, proteomic western blotting assays revealed significantly activates p38 mitogen-activated protein kinase MAPK pathway increases phosphorylation heat shock 27 (HSP27). results also suggest E2F1-dependent...
Metal and its oxide nanoparticles show ideal pharmacological activity, especially in anti-tumor therapy. Our previous study demonstrated that cuprous (CONPs) selectively induce apoptosis of tumor cells vitro. To explore the properties CONPs vivo, we used particles to treat mouse subcutaneous melanoma metastatic lung tumors, based on B16-F10 cells, by intratumoral systemic injections, respectively. The results showed significantly reduced growth melanoma, inhibited metastasis increased...
Abstract Long noncoding RNAs (lncRNAs) are implicated in renal cell carcinoma (RCC), but remain largely unclear. Using publicly available transcriptome sequencing data from cancer ( n = 703) and integrating bioinformatics analyses, we screened identified a valuable lncRNA, EGFR-AS1. In our validation cohort 204), EGFR-AS1 was significantly upregulated RCC tissues P < 0.001). Gain-of-function loss-of-function studies showed that promoted proliferation invasion vitro vivo. Based on previous...
Systemic analyses using large-scale genomic profiles have successfully identified cancer-driving somatic copy number variations (SCNVs) loci. However, functions of vast focal SCNVs in "protein-coding gene desert" regions are largely unknown. The integrative analysis long noncoding RNA (lncRNA) expression with hepatocellular carcinoma (HCC) led us to identify the recurrent deletion lncRNA-PRAL (p53 regulation-associated lncRNA) on chromosome 17p13.1, whose alterations were significantly...
To explore whether plasma circular RNAs (circRNAs) can diagnose hepatitis B virus (HBV)‐related hepatocellular carcinoma (HCC), microarray and qPCR were used to identify circRNAs that increased in HBV‐related HCC patients compared controls (including healthy controls, chronic liver cirrhosis). A logistic regression model was constructed using a training set (n = 313) then validated another two independent sets ( n 306 526, respectively). Area under the receiver operating characteristic curve...
Abstract Multifunctional N 6-methyladenosine (m6A) has been revealed to be an important epigenetic component in various physiological and pathological processes, but its role female ovarian aging remains unclear. Thus, we demonstrated m6A demethylase FTO downregulation the ensuing increased granulosa cells (GCs) of human aged ovaries, while FTO-knockdown GCs showed faster aging-related phenotypes mediated. Using m6A-RNA-sequence technique (m6A-seq), was found FOS-mRNA-3′UTR, which is...
Background and Aims HBV‐pgRNA (pregenomic RNA) has been proposed for predicting the response of nucleos(t)ide analogue (NA) treatment, guiding discontinuation NA therapy monitoring emergence viral mutations. However, contributions to HCC remain open study. Approach Results Double‐center cohorts serum samples with undetectable HBV‐DNA (below lower limit detection) were obtained from long‐term NA‐treated (≥48 weeks) HBV‐related patients. The correlation between pgRNA concentration prognosis...
Abstract Without intervention, a considerable proportion of patients with metabolism‐associated fatty liver disease (MAFLD) will progress from simple steatosis to steatohepatitis (MASH), fibrosis, and even hepatocellular carcinoma. However, the molecular mechanisms that control progressive MAFLD have yet be fully determined. Here, we unraveled expression N6-methyladenosine (m6A) methyltransferase METTL14 is remarkably downregulated in livers both several murine models MAFLD, whereas...
Current literature provided information that alteration in microRNA expression impacted sensitivity or resistance of certain tumor types to anticancer treatment, including the possible intracellular pathways. The microRNA-23a (miR-23a)-regulated apoptosis response 5-fluorouracil (5-FU)-induced mitochondria-mediated apoptotic pathway was determined this study. miR-23a 5-FU-treated and untreated colon cancer cells tissues assessed using real-time PCR analysis. To determine function regulation...