A5101584506- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Microtubule and mitosis dynamics
- Glycosylation and Glycoproteins Research
- Neuroblastoma Research and Treatments
- Cell Adhesion Molecules Research
- Cancer-related Molecular Pathways
- Proteoglycans and glycosaminoglycans research
- Pregnancy and preeclampsia studies
Xi'an Medical University
2021
Hebei Medical University
2019
Second Hospital of Hebei Medical University
2019
Henry Ford Hospital
2014
Dysfunctions of epithelial–mesenchymal transition (EMT)-regulated cell migration and invasion have been involved in the pathogenesis pre-eclampsia (PE). However, role circRNAs EMT PE has not widely investigated. In this study, we identified that circTNRC18 was upregulated placentas compared with normal pregnancy placentas. Moreover, negatively regulated trophoblast EMT. Overexpression reduced while depletion enhanced Mechanistically, sponged miR-762 contributed to inhibit activity elevated...
Circular RNA checkpoint with forkhead and ring finger domains (circ_CHFR) were reported to regulate vascular smooth muscle cell (VSMC) dysfunction during atherosclerosis (AS). However, the molecule mechanism of circ_CHFR in AS remains largely unclear. Human VSMCs (HVSMCs) exposed platelet-derived growth factor-BB (PDGF-BB) vitro. Levels circ_CHFR, microRNA (miR)-149-5p, neuropilin 2 (NRP2) determined using quantitative real-time polymerase chain reaction western blot. Cell proliferation,...
Abstract Heparanase is an endoglycosidase that degrades heparan sulfate, the main polysaccharide constituent of extracellular matrix (ECM) and basement membrane. Expression heparanase gene associated with invasion metastatic potential a variety tumor-derived cell types. However, roles in regulation expression subsequent function changes other than are not clear. In current study, we overexpressed human U251n glioma line. We found heparanase-overexpression significantly increased invasion,...
LncRNA CCDC26 is aberrantly expressed in myeloid leukemia (ML) and promotes progression, but the potential mechanism of regulating ML progression unclear. In this study, we observed that lncRNA was upregulated both chronic acute cell lines. promoted proliferation invasion K562 HL-60 cells, which determined by counting kit-8 test Transwell assay. Flow cytometry showed inhibited apoptosis. Bioinformatics expression correlation analyses revealed there a interaction between CUGBP Elav-like...