A5072193931- Cancer-related molecular mechanisms research
- Natural Products and Biological Research
- Machine Learning in Bioinformatics
- RNA modifications and cancer
- Genomics and Phylogenetic Studies
- RNA and protein synthesis mechanisms
- Computational Drug Discovery Methods
- Bioinformatics and Genomic Networks
- Lung Cancer Treatments and Mutations
- Aquaculture disease management and microbiota
- Identification and Quantification in Food
- RNA Research and Splicing
- Antimicrobial Peptides and Activities
- Lung Cancer Research Studies
- Chemical Synthesis and Analysis
- vaccines and immunoinformatics approaches
- Medical Image Segmentation Techniques
- Gene expression and cancer classification
- Advanced Algorithms and Applications
- Cardiovascular Health and Risk Factors
- Advanced Decision-Making Techniques
- Cancer Immunotherapy and Biomarkers
- Cell Image Analysis Techniques
- Image Retrieval and Classification Techniques
- Engineering and Test Systems
Guizhou Academy of Agricultural Sciences
2017-2025
Changzhou University
2021-2024
Changzhou No.2 People's Hospital
2022-2024
Nanjing Medical University
2022-2024
Zhengzhou University
2015-2024
Henan Cancer Hospital
2012-2024
Henan Provincial People's Hospital
2023
Data Assurance and Communication Security
2023
Jilin University
2006-2022
China-US (Henan) Hormel Cancer Institute
2015-2022
Survival of patients with hepatocellular carcinoma (HCC) remains poor, which is largely attributed to active angiogenesis. However, the mechanisms underlying angiogenesis in HCC remain be discovered. In this study, we found that long noncoding RNA associated microvascular invasion (lncRNA MVIH) HCC) was generally overexpressed HCC. a cohort 215 patients, overexpression MVIH frequent (P = 0.016) and higher tumor node metastasis stage 0.009) as well decreased recurrence-free survival (RFS) <...
Downregulation of Aldolase B (ALDOB) has been reported in hepatocellular carcinoma. However, its clinical significance and role pathogenesis HCC remain largely unknown.We analyzed the expression ALDOB features a large cohort 313 patients using tissue microarray immunohistochemistry. Moreover, function stably overexpressed cells was explored vitro vivo. Gene analysis performed on ALDOB-overexpressing SMMC7721 to elucidate mechanism action.ALDOB downregulation significantly correlated with...
Long non-coding RNA (LncRNA) and microRNA (miRNA) are both RNAs that play significant regulatory roles in many life processes. There is cumulating evidence showing the interaction patterns between lncRNAs miRNAs highly related to cancer development, gene regulation, cellular metabolic process, etc. Contemporaneously, with rapid development of sequence technology, numerous novel have been found, which might help explore regulated patterns. However, increasing unknown interactions may hinder...
Abstract The phosphoinositide 3-kinase (PI3-K)/Akt signaling pathway is important in the regulation of cell proliferation through its production phosphatidylinositol 3,4,5-triphosphate (PIP3). Activation this frequently observed human cancers, including non-small lung carcinoma. PI3-K/Akt negatively regulated by dual-specificity phosphatase and tensin homolog (PTEN) protein. PTEN acts as a direct antagonist PI3-K dephosphorylating PIP3. Studies have shown that activity inhibited PREX2,...
Seed dormancy is a common physiological phenomenon during storage which has great impact on timely germination of seeds. An in-depth analysis the and molecular mechanisms perilla seed release significance for cultivating high-vigor varieties. We used gibberellin A3-soaked seeds (GA), natural dormancy-release (CK) water-soaked (WA) to study changes in transcriptome metabolome release. The test revealed that optimum concentration A3 releasing from was 200 mg/L. results plant hormone signal...
Perilla frutescen is used as traditional food and medicine in East Asia. Its seeds contain high levels of α-linolenic acid (ALA), which important for health, but scarce our daily meals. Previous reports on RNA-seq perilla seed had identified fatty (FA) triacylglycerol (TAG) synthesis genes, the underlying mechanism ALA biosynthesis its regulation still need to be further explored. So we conducted Illumina RNA-sequencing seven temporal developmental stages seeds. Sequencing generated a total...
The RAS/RAF/MEK/ERK and PI3K/AKT/mTOR signaling pathways all belong to mitogen-activated protein kinase (MAPK) pathways, Mutations in any one of the upstream genes (such as RAS gene or BRAF gene) may be transmitted through transcription translation, resulting abnormal activation pathway. This study investigated relationship between KRAS mutation clinicopathological features prognosis colorectal cancer (CRC), effect mutations on its associated proteins CRC, with an aim clarify cause tumor...
Long non-coding RNA (lncRNA) is one of the most essential forms transcripts, playing crucial regulatory roles in development cancers and diseases without protein-coding ability. It was assumed that short ORFs (sORFs) lncRNA were weak to translate proteins. However, recent research has shown sORFs can encode peptides, which increases difficulty identify lncRNA. Therefore, identifying lncRNAs with facilitates finding novel factors. In this paper, we propose LncCat for based on category...
Background: Clustering of cardiovascular disease (CVD) risk factors constitutes a major public health challenge. Although number researchers have investigated the CVD factor clusters in China, little is known about related prevalence and clustering associated with demographics Jilin Province China; this study aims to reveal that relationship. Methods: A cross-sectional survey based on sample 16,834 adults aged 18 79 years was conducted 2012. The were analysed through complex weighted...
Abstract Measuring conditional relatedness between a pair of genes is fundamental technique and still significant challenge in computational biology. Such can be assessed by gene expression similarities while suffering high false discovery rates. Meanwhile, other types features, e.g., prior-knowledge based similarities, only viable for measuring global relatedness. In this paper, we propose novel machine learning model, named Multi-Features Relatedness (MFR), accurately incorporating with an...
Cancer is one of the most dangerous threats to human health. One issues drug resistance action, which leads side effects after treatment. Numerous therapies have endeavored relieve action. Recently, anticancer peptides could be a novel and promising candidate, can inhibit tumor cell proliferation, migration, suppress formation blood vessels, with fewer effects. However, it costly, laborious time consuming identify by biological experiments high throughput. Therefore, accurately identifying...
This paper investigates how to perform efficient and robust foreground detection in challenging scenarios by leveraging multiple source data. We propose a novel approach, called collaborative low-rank decomposition (CLoD), for grayscale-thermal detection. Given two data matrices accumulating sequential frames from the grayscale thermal videos, CLoD detects objects as sparse noises against backgrounds with low rank structure, also incorporates modality weights achieve adaptive fusion of...
CVD risk factors (hypertension, dyslipidemia and diabetes) MetS are closely related to obesity. The selection of an optimal cut-off for various obesity indices is particularly important predict MetS.Sixteen thousand seven hundred sixty-six participants aged 18-79 were recruited in Jilin Province 2012. Five indices, including BMI, WC, WHR, WHtR BAI investigated. ROC analyses used evaluate the predictive ability determine values MetS.BMI had highest adjusted ORs, ORs hypertension,...
Gallbladder cancer (GBC) is a highly malignant tumor with extremely poor prognosis. Previous studies have suggested that the carcinogenesis and progression of GBC multi-stage multi-step process, but most them focused on genome changes. And few just compared transcriptome differences between tissues adjacent noncancerous tissues. The changes, relating to every stage evolution, rarely been studied. We selected three cases normal gallbladder, four gallbladder chronic inflammation induced by...