Qingyi Wei
A5060545230- DNA Repair Mechanisms
- RNA modifications and cancer
- Head and Neck Cancer Studies
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- Carcinogens and Genotoxicity Assessment
- Genetic factors in colorectal cancer
- Lung Cancer Treatments and Mutations
- MicroRNA in disease regulation
- Glutathione Transferases and Polymorphisms
- Cutaneous Melanoma Detection and Management
- Folate and B Vitamins Research
- Cancer-related gene regulation
- Cancer Genomics and Diagnostics
- BRCA gene mutations in cancer
- Genomics and Chromatin Dynamics
- Circular RNAs in diseases
- melanin and skin pigmentation
- Skin Protection and Aging
- Genetic Associations and Epidemiology
- Melanoma and MAPK Pathways
- Heat shock proteins research
- Esophageal Cancer Research and Treatment
- Effects of Radiation Exposure
Shanghai Civil Aviation College
2025
Duke University
2015-2024
Duke Medical Center
2015-2024
Duke University Hospital
2014-2024
China Medical University
2024
South China University of Technology
2014-2024
Sichuan Normal University
2024
The University of Texas MD Anderson Cancer Center
2009-2023
Fudan University Shanghai Cancer Center
2014-2023
Duke Cancer Institute
2014-2023
Abstract Background: The magnitude of risk conferred by the interaction between tobacco and alcohol use on head neck cancers is not clear because studies have used various methods to quantify excess cancer burden. Methods: We analyzed individual-level pooled data from 17 European American case-control (11,221 cases 16,168 controls) participating in International Head Neck Cancer Epidemiology consortium. estimated multiplicative parameter (ψ) population attributable risks (PAR). Results: A...
Only a fraction of cigarette smokers develop lung cancer, suggesting that people differ in their susceptibility to this disease. We investigated whether differences DNA repair capacity (DRC) for repairing tobacco carcinogen-induced damage are associated with differential cancer.From August 1, 1995, through April 30, 1999, we conducted hospital-based, case-control study 316 newly diagnosed cancer patients and cancer-free control subjects matched on age, sex, smoking status. DRC was measured...
This molecular epidemiology study examines the DNA-repair capacities (DRCs) of basal cell carcinoma (BCC) skin cancer patients (88) and their controls (135) by using a plasmid/host-cell reactivation assay. In this assay UV-damaged expression vector plasmid is transfected into peripheral blood T lymphocytes from subjects. The host-cellular repair enzymes photochemical damage in plasmid, 40 hr later plasmid-encoded reporter chloramphenicol acetyltransferase measured. An age-related decline...
Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved susceptibility to etiologically complex disease. We conducted a GWAS identify upper aero-digestive tract (UADT) cancers. genotyping was carried out using the Illumina HumanHap300 beadchips 2,091 UADT cancer cases and 3,513 controls from two large European multi-centre studies, as well 4,821 generic controls. The 19 top-ranked variants were investigated further an additional 6,514...
The early detection of hepatocellular carcinoma (HCC) presents a challenge because the lack specific biomarkers. Serum/plasma microRNAs (miRNAs) can discriminate HCC patients from controls. We aimed to identify and evaluate HCC‐associated plasma miRNAs originating liver as biomarkers for detecting HCC. In this multicenter three‐phase study, we first performed screening using both (HCC before after transplantation or hepatectomy) tissue samples (HCC, para‐carcinoma cirrhotic tissues). Then,...
DNA repair capacity (DRC) plays an important role in genetic susceptibility to cancer. Polymorphisms of a number genes involved several distinct pathways have been identified. However, their effects on function not well characterized. We demonstrated previously that DRC for removal benzo[a]pyrene diol epoxide-induced damage measured by host-cell reactivation assay was modulated two XPD/ERCC2 polymorphisms lung In this report, we investigated the association between phenotype ultraviolet...
NRAS and BRAF mutations are common in cutaneous melanomas, although rarely detected mutually the same tumor. Distinct clinical correlates of these have not been described, despite vitro data suggesting enhanced oncogenic effects. This study was designed to test hypothesis that primary human melanomas harboring or display a more aggressive phenotype than tumors wild type at both loci.Microdissection 223 carried out, followed by determination mutational status. Genotypic findings were...
Abstract The etiology of esophageal squamous cell carcinoma (ESCC) has been shown to be associated with genetic and certain environmental factors that produce DNA damage. Base excision repair (BER) genes are responsible for damage caused by reactive oxygen species other electrophiles therefore good candidate susceptibility ESCC. We first screened eight BER new potential functional polymorphisms resequencing 27 samples. then identified genotyped important tagging single nucleotide (SNPs) in a...
Abstract Background. While the attributed risk factors for vast majority of patients with squamous cell carcinoma head and neck (SCCHN) are smoking alcohol abuse, there appears to be a rising proportion SCCHN who report no significant or drinking history. This study reports demographic potential large series never smoker–never drinker (NSND) patients. Methods. All subjects were participants in prospective epidemiologic incident SCCHN. We obtained data, clinical characteristics, etiologic 172...
It has been demonstrated that there are abundant stable microRNAs (miRNAs) in plasma/serum, which can be detected and potentially disease specific. However, the lack of suitable endogenous controls for serum miRNA detection is restriction widely usage this kind biomarkers between-laboratory comparison findings. We first systematically screened control miRNAs (ECMs) by testing 10 pooling samples (using both Solexa sequencing TaqMan low density array) 50 individual quantitative reverse...
We performed a multistage genome-wide association study of melanoma. In discovery cohort 1804 melanoma cases and 1026 controls, we identified loci at chromosomes 15q13.1 (HERC2/OCA2 region) 16q24.3 (MC1R) regions that reached significance within this also found strong evidence for genetic effects on susceptibility to from markers chromosome 9p21.3 in the p16/ARF region 1q21.3 (ARNT/LASS2/ANXA9 region). The most significant single-nucleotide polymorphisms (SNPs) locus (rs1129038 rs12913832)...
Although cigarette smoking and alcohol consumption increase risk for head neck cancers, there have been few attempts to model risks quantitatively formally evaluate cancer site-specific risks. The authors pooled data from 15 case-control studies modeled the excess odds ratio (EOR) assess by total exposure (pack-years drink-years) its modification rate (cigarettes/day drinks/day). analysis included 1,761 laryngeal, 2,453 pharyngeal, 1,990 oral cavity 2,551 3,693 3,116 oval with over 8,000...