Lenka Foretová

ORCID: 0000-0003-0494-2620
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About
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Research Areas
  • BRCA gene mutations in cancer
  • Cancer Genomics and Diagnostics
  • Lymphoma Diagnosis and Treatment
  • Genetic factors in colorectal cancer
  • Renal cell carcinoma treatment
  • Genetic Associations and Epidemiology
  • Occupational and environmental lung diseases
  • Nutrition, Genetics, and Disease
  • Air Quality and Health Impacts
  • DNA Repair Mechanisms
  • Epigenetics and DNA Methylation
  • Chronic Lymphocytic Leukemia Research
  • Viral-associated cancers and disorders
  • Renal and related cancers
  • Carcinogens and Genotoxicity Assessment
  • Ovarian cancer diagnosis and treatment
  • Genomic variations and chromosomal abnormalities
  • CRISPR and Genetic Engineering
  • Multiple Myeloma Research and Treatments
  • Cancer Risks and Factors
  • Multiple and Secondary Primary Cancers
  • Pancreatic and Hepatic Oncology Research
  • RNA modifications and cancer
  • Global Cancer Incidence and Screening
  • Eating Disorders and Behaviors

Masaryk Memorial Cancer Institute
2015-2024

Centre international de recherche sur le cancer
2005-2023

Cancer Genetics (United States)
2015-2023

Czech Academy of Sciences, Institute of Molecular Genetics
2010-2023

Czech Academy of Sciences
2023

National Cancer Institute
2010-2021

Division of Cancer Epidemiology and Genetics
2010-2021

Carrier (United States)
2021

Cohort (United Kingdom)
2021

Masaryk University
2007-2020

<h3>Importance</h3> The clinical management of<i>BRCA1</i>and<i>BRCA2</i>mutation carriers requires accurate, prospective cancer risk estimates. <h3>Objectives</h3> To estimate age-specific risks of breast, ovarian, and contralateral breast for mutation to evaluate modification by family history location. <h3>Design, Setting, Participants</h3> Prospective cohort study 6036<i>BRCA1</i>and 3820<i>BRCA2</i>female (5046 unaffected 4810 with or ovarian both at baseline) recruited in 1997-2011...

10.1001/jama.2017.7112 article EN JAMA 2017-06-20
Hunna J. Watson Zeynep Yılmaz Laura M. Thornton Christopher Hübel Jonathan R. I. Coleman and 95 more Héléna A. Gaspar Julien Bryois Anke Hinney Virpi Leppä Manuel Mattheisen Sarah E. Medland Stephan Ripke Shuyang Yao Paola Giusti‐Rodríguez Ken B. Hanscombe Kirstin L. Purves Roger A.H. Adan Lars Alfredsson Tetsuya Ando Ole A. Andreassen Jessica H. Baker Wade H. Berrettini Ilka Boehm Claudette Boni Vesna Boraska Perica Katharina Buehren Roland Burghardt Matteo Cassina Sven Cichon Maurizio Clementi Roger D. Cone Philippe Courtet Scott J. Crow James J. Crowley Unna N. Danner Oliver S. P. Davis Martina de Zwaan George Dedoussis Daniela Degortes Janiece E. DeSocio Danielle M. Dick Dimitris Dikeos Christian Dina Monika Dmitrzak‐Węglarz Elisa Docampo Laramie E. Duncan Karin Egberts Stefan Ehrlich Geòrgia Escaramís Tõnu Esko Xavier Estivill Anne Farmer Angela Favaro Fernando Fernández‐Aranda Manfred M. Fichter Krista Fischer Manuel Föcker Lenka Foretová Andreas J. Forstner Monica Forzan Christopher S. Franklin Steven Gallinger Ina Giegling Johanna Giuranna Fragiskos Gonidakis Philip Gorwood Monica Gratacos Mayora Sébastien Guillaume Yiran Guo Hákon Hákonarson Konstantinos Hatzikotoulas Joanna Hauser Johannes Hebebrand Sietske G. Helder Stefan Herms Beate Herpertz‐Dahlmann Wolfgang Herzog Laura M. Huckins James I. Hudson Hartmut Imgart Hidetoshi Inoko Vladimí­r Janout Susana Jiménez‐Múrcia Antonio Julià Gursharan Kalsi Deborah Kaminská Jaakko Kaprio Leila Karhunen Andreas Karwautz Martien J. Kas James L. Kennedy Anna Keski‐Rahkonen Kirsty Kiezebrink Youl‐Ri Kim Lars Klareskog Kelly L. Klump Gun Peggy Knudsen Maria C. La Via Stéphanie Le Hellard Robert D. Levitan

10.1038/s41588-019-0439-2 article EN Nature Genetics 2019-07-15

Genetic testing for inherited mutations in BRCA1 and BRCA2 has become integral to the care of women with a severe family history breast or ovarian cancer, but an unknown number patients receive negative (ie, wild-type) results when they actually carry pathogenic mutation. Furthermore, other cancer genes generally are not evaluated.To determine frequency types undetected cancer-predisposing BRCA1, BRCA2, CHEK2, TP53, PTEN among from high-risk families (wild-type) genetic test BRCA2.Between...

10.1001/jama.295.12.1379 article EN JAMA 2006-03-21

Lung cancer is mainly caused by smoking, but the quantitative relations between smoking and histologic subtypes of lung remain inconclusive. By using one largest datasets ever assembled, we explored impact on risks major cell types cancer. This pooled analysis included 13,169 cases 16,010 controls from Europe Canada. Studies with population comprised 66.5% subjects. Adenocarcinoma (AdCa) was most prevalent subtype in never smokers women. Squamous carcinoma (SqCC) predominated male smokers....

10.1002/ijc.27339 article EN International Journal of Cancer 2011-11-02

10.1038/ng.3002 article EN Nature Genetics 2014-06-01
James McKay Thérèse Truong Valérie Gaborieau Amélie Chabrier Shu-Chun Chuang and 95 more Graham Byrnes Давид Заридзе Oxana Shangina Neonila Szeszenia‐Dąbrowska Jolanta Lissowska Péter Rudnai Eleonóra Fabiánová Alexandru Bucur Vladimír Bencko Ivana Holcátová Vladimí­r Janout Lenka Foretová Παγώνα Λάγιου Dimitrios Trichopoulos Simone Benhamou Christine Bouchardy Wolfgang Ahrens Franco Merletti Lorenzo Richiardi Renato Talamini Luigi Barzan Kristina Kjærheim Gary J. Macfarlane Tatiana V. Macfarlane Lorenzo Simonato Cristina Canova Antonio Agudo Xavier Castellsagué Ray Lowry David I. Conway Patricia A. McKinney Claire M. Healy Mary Toner Ariana Znaor María Paula Curado Sérgio Koifman Ana Menezes Victor Wünsch‐Filho José Eluf‐Neto Letícia Fernández Garrote Stefania Boccia Gabriella Cadoni Dario Arzani Andrew F. Olshan Mark C. Weissler William K. Funkhouser Jingchun Luo Jan Lubiński Joanna Trubicka Marcin Lener Dorota Oszutowska–Mazurek Stephen M. Schwartz Chu Chen Sherianne Fish David R. Doody Joshua Muscat Philip Lazarus Carla J. Gallagher Shen-Chih Chang Zuo‐Feng Zhang Qingyi Wei Erich M. Sturgis Li‐E Wang Silvia Franceschi Rolando Herrero Karl T. Kelsey Michael D. McClean Carmen J. Marsit Heather H. Nelson Marjorie Romkes Shama Buch Tomoko Nukui Shilong Zhong Martin Lacko Johannes J. Manni Wilbert H.M. Peters Rayjean J. Hung Esther M. John Lars J. Vatten Inger Njølstad Gary E. Goodman John K. Field Triantafillos Liloglou Paolo Vineis Françoise Clavel‐Chapelon Domenico Palli ­Rosario ­Tumino Vittorio Krogh Salvatore Panico Carlos A. González J. Ramón Quirós Carmen Martı́nez Carmen Navarro Eva Ardanáz Nerea Larrañaga

Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved susceptibility to etiologically complex disease. We conducted a GWAS identify upper aero-digestive tract (UADT) cancers. genotyping was carried out using the Illumina HumanHap300 beadchips 2,091 UADT cancer cases and 3,513 controls from two large European multi-centre studies, as well 4,821 generic controls. The 19 top-ranked variants were investigated further an additional 6,514...

10.1371/journal.pgen.1001333 article EN cc-by PLoS Genetics 2011-03-17
Julien Bryois Nathan Skene Thomas Hansen Lisette J. A. Kogelman Hunna J. Watson and 95 more Zijing Liu Roger A.H. Adan Lars Alfredsson Tetsuya Ando Ole A. Andreassen Jessica H. Baker Andrew W. Bergen Wade H. Berrettini Andreas Birgegård Joseph M. Boden Ilka Boehm Claudette Boni Vesna Boraska Perica Harry Brandt Gerome Breen Julien Bryois Katharina Buehren Cynthia M. Bulik Roland Burghardt Matteo Cassina Sven Cichon Maurizio Clementi Jonathan R. I. Coleman Roger D. Cone Philippe Courtet Steven Crawford Scott J. Crow James L. Crowley Unna N. Danner Oliver S. P. Davis Martina de Zwaan George Dedoussis Daniela Degortes Janiece E. DeSocio Danielle M. Dick Dimitris Dikeos Christian Dina Monika Dmitrzak‐Węglarz Elisa Docampo Martínez Laramie E. Duncan Karin Egberts Stefan Ehrlich Geòrgia Escaramís Tõnu Esko Xavier Estivill Anne Farmer Angela Favaro Fernando Fernández‐Aranda Manfred Fichter Krista Fischer Manuel Föcker Lenka Foretová Andreas J. Forstner Monica Forzan C. Franklin Steven Gallinger Héléna A. Gaspar Ina Giegling Johanna Giuranna Paola Giusti-Rodríquez Fragiskos Gonidakis Scott D. Gordon Philip Gorwood Monica Gratacos Mayora Jakob Grove Sébastien Guillaume Yiran Guo Hákon Hákonarson Katherine A. Halmi Ken B. Hanscombe Konstantinos Hatzikotoulas Joanna Hauser Johannes Hebebrand Sietske G. Helder Anjali K. Henders Stefan Herms Beate Herpertz‐Dahlmann Wolfgang Herzog Anke Hinney L. John Horwood Christopher Hübel Laura M. Huckins James I. Hudson Hartmut Imgart Hidetoshi Inoko Vladimí­r Janout Susana Jiménez‐Múrcia Craig Johnson Jennifer Jordan Antonio Julià Anders Juréus Gursharan Kalsi Deborah Kaminská Allan S. Kaplan Jaakko Kaprio

10.1038/s41588-020-0610-9 article EN Nature Genetics 2020-04-27
Timothy R. Rebbeck Tara M. Friebel Eitan Friedman Ute Hamann Dezheng Huo and 95 more Ava Kwong Edith Oláh Olufunmilayo I. Olopade Ángela R. Solano Soo‐Hwang Teo Mads Thomassen Jeffrey N. Weitzel TL Chan Fergus J. Couch David E. Goldgar Torben A. Kruse Edenir Inêz Palmero Sue K. Park Diana Torres Elizabeth J. van Rensburg Lesley McGuffog Michael T. Parsons Goska Leslie Cora M. Aalfs Julio E. Abugattas Julian Adlard Simona Agata Kristiina Aittomäki Lesley Andrews Irene L. Andrulis Aðalgeir Arason Norbert Arnold Banu Arun Ella Asseryanis Leo Auerbach Jacopo Azzollini Judith Balmañà Monica Barile Rósa B. Barkardóttir Daniel Barrowdale Javier Benı́tez Andreas Berger Raanan Berger Amie Blanco Kathleen R. Blazer Marinus J. Blok Valérie Bonadona Bernardo Bonanni Angela R. Bradbury Carole Brewer Bruno Buecher Saundra S. Buys Trinidad Caldés Almuth Caliebe Maria A. Caligo Ian Campbell Sandrine M. Caputo Jocelyne Chiquette Wendy K. Chung Kathleen Claes J. Margriet Collée Jackie Cook Rosemarie Davidson Miguel de la Hoya Kim De Leeneer Antoine De Pauw Capucine Delnatte Orland Dı́ez Yuan Chun Ding Nina Ditsch Susan M. Domchek Cecilia M. Dorfling Carolina Velázquez Bernd Dworniczak Jacqueline Eason Douglas F. Easton Rosalind A. Eeles Hans Ehrencrona Bent Ejlertsen Christoph Engel Stefanie Engert D. Gareth Evans Laurence Faivre Lídia Feliubadaló Sandra Fert Ferrer Lenka Foretová Jeffrey M. Fowler Debra Frost Henrique C.R. Galvão Patricia A. Ganz Judy E. Garber Marion Gauthier‐Villars Andrea Gehrig Anne–Marie Gerdes Paul Gesta Giuseppe Giannini Sophie Giraud Gord Glendon Andrew K. Godwin Mark H. Greene

The prevalence and spectrum of germline mutations in BRCA1 BRCA2 have been reported single populations, with the majority reports focused on White Europe North America. Consortium Investigators Modifiers BRCA1/2 (CIMBA) has assembled data 18,435 families 11,351 ascertained from 69 centers 49 countries six continents. This study comprehensively describes characteristics 1,650 unique 1,731 deleterious (disease-associated) identified CIMBA database. We observed substantial variation mutation...

10.1002/humu.23406 article EN Human Mutation 2018-02-15
Laura Fachal Hugues Aschard Jonathan Beesley Daniel R. Barnes Jamie Allen and 95 more Siddhartha Kar Karen A. Pooley Joe Dennis Kyriaki Michailidou Constance Turman Penny Soucy Audrey Lemaçon Michael Lush Jonathan P. Tyrer Maya Ghoussaini Mahdi Moradi Marjaneh Xia Jiang Simona Agata Kristiina Aittomäki M. Rosario Alonso Irene L. Andrulis Hoda Anton‐Culver Natalia Antonenkova Aðalgeir Arason Volker Arndt Kristan J. Aronson Banu K. Arun Bernd Auber Paul L. Auer Jacopo Azzollini Judith Balmañà Rósa B. Barkardóttir Daniel Barrowdale Alicia Beeghly‐Fadiel Javier Benı́tez Marina Bermisheva Katarzyna Białkowska Amie Blanco Carl Blomqvist William J. Blot Natalia Bogdanova Stig E. Bojesen Manjeet K. Bolla Bernardo Bonanni Åke Borg Kristin Bosse Hiltrud Brauch Hermann Brenner Ignacio Briceño Ian W. Brock Angela Brooks‐Wilson Thomas Brüning Barbara Burwinkel Saundra S. Buys Qiuyin Cai Trinidad Caldés Maria A. Caligo Nicola J. Camp Ian Campbell Federico Canzian Jason S. Carroll Brian D. Carter Jose E. Castelao Jocelyne Chiquette Hans Christiansen Wendy K. Chung Kathleen Claes Christine L. Clarke Margriet Collée Sten Cornelissen Fergus J. Couch Angela Cox Simon S. Cross Cezary Cybulski Kamila Czene Mary B. Daly Miguel de la Hoya Peter Devilee Orland Dı́ez Yuan Chun Ding Gillian S. Dite Susan M. Domchek Thilo Dörk Isabel dos‐Santos‐Silva Arnaud Droit Stéphane Dubois Martine Dumont M. Durán Lorraine Durcan Miriam Dwek Diana Eccles Christoph Engel Mikael Eriksson D. Gareth Evans Peter A. Fasching Olivia Fletcher Giuseppe Floris Henrik Flyger Lenka Foretová William D. Foulkes

10.1038/s41588-019-0537-1 article EN Nature Genetics 2020-01-01

Abstract International differences in the incidence of many cancer types indicate existence carcinogen exposures that have not yet been identified by conventional epidemiology make a substantial contribution to burden 1 . In clear cell renal carcinoma, obesity, hypertension and tobacco smoking are risk factors, but they do explain geographical variation its 2 Underlying causes can be inferred sequencing genomes cancers from populations with different rates detecting patterns somatic...

10.1038/s41586-024-07368-2 article EN cc-by Nature 2024-05-01
Mark P. Purdue Mattias Johansson Diana Zélénika Jorge R. Toro Ghislaine Scélo and 95 more Lee E. Moore Egor Prokhortchouk Xifeng Wu Lambertus A. Kiemeney Valérie Gaborieau Kevin B. Jacobs Wong‐Ho Chow Давид Заридзе В. Б. Матвеев Jan Lubiński Joanna Trubicka Neonila Szeszenia‐Dąbrowska Jolanta Lissowska Péter Rudnai Eleonóra Fabiánová Alexandru Bucur Vladimír Bencko Lenka Foretová Vladimí­r Janout Paolo Boffetta Joanne S. Colt Faith G. Davis Kendra Schwartz Rosamonde E. Banks Peter J. Selby Patricia Harnden Christine D. Berg Ann W. Hsing Robert L. Grubb Heiner Boeing Paolo Vineis Françoise Clavel-Chapelon Domenico Palli ­Rosario ­Tumino Vittorio Krogh Salvatore Panico Eric J. Duell J. Ramón Quirós María‐José Sánchez Carmen Navarro Eva Ardanáz Miren Dorronsoro Kay‐Tee Khaw Naomi E. Allen H. Bas Bueno-de-Mesquita Petra H. Peeters Dimitrios Trichopoulos Jakob Linseisen Börje Ljungberg Kim Overvad Anne Tjønneland Isabelle Romieu Elio Ríboli Anush Mukeria Oxana Shangina Victoria L. Stevens Michael J. Thun W. Ryan Diver Susan M. Gapstur Paul D.P. Pharoah Douglas F. Easton Demetrius Albanes Stephanie J. Weinstein Jarmo Virtamo Lars J. Vatten Kristian Hveem Inger Njølstad Grethe S. Tell Camilla Stoltenberg Rajiv Kumar Kvetoslava Koppová Olivier Cussenot Simone Benhamou Egbert Oosterwijk Sita H. Vermeulen Katja K.H. Aben Saskia L. van der Marel Yuanqing Ye Christopher G. Wood Xia Pu Alexander M. Mazur Eugenia Boulygina Nikolay Chekanov Mario Foglio Doris Lechner Marta Gut Simon Heath Hélène Blanché Amy Hutchinson Gilles Thomas Zhaoming Wang Meredith Yeager Joseph F. Fraumeni K. G. Skryabin James McKay

10.1038/ng.723 article EN Nature Genetics 2010-12-05
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