Lenka Foretová
- BRCA gene mutations in cancer
- Cancer Genomics and Diagnostics
- Lymphoma Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Renal cell carcinoma treatment
- Genetic Associations and Epidemiology
- Occupational and environmental lung diseases
- Nutrition, Genetics, and Disease
- Air Quality and Health Impacts
- DNA Repair Mechanisms
- Epigenetics and DNA Methylation
- Chronic Lymphocytic Leukemia Research
- Viral-associated cancers and disorders
- Renal and related cancers
- Carcinogens and Genotoxicity Assessment
- Ovarian cancer diagnosis and treatment
- Genomic variations and chromosomal abnormalities
- CRISPR and Genetic Engineering
- Multiple Myeloma Research and Treatments
- Cancer Risks and Factors
- Multiple and Secondary Primary Cancers
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Global Cancer Incidence and Screening
- Eating Disorders and Behaviors
Masaryk Memorial Cancer Institute
2015-2024
Centre international de recherche sur le cancer
2005-2023
Cancer Genetics (United States)
2015-2023
Czech Academy of Sciences, Institute of Molecular Genetics
2010-2023
Czech Academy of Sciences
2023
National Cancer Institute
2010-2021
Division of Cancer Epidemiology and Genetics
2010-2021
Carrier (United States)
2021
Cohort (United Kingdom)
2021
Masaryk University
2007-2020
<h3>Importance</h3> The clinical management of<i>BRCA1</i>and<i>BRCA2</i>mutation carriers requires accurate, prospective cancer risk estimates. <h3>Objectives</h3> To estimate age-specific risks of breast, ovarian, and contralateral breast for mutation to evaluate modification by family history location. <h3>Design, Setting, Participants</h3> Prospective cohort study 6036<i>BRCA1</i>and 3820<i>BRCA2</i>female (5046 unaffected 4810 with or ovarian both at baseline) recruited in 1997-2011...
Genetic testing for inherited mutations in BRCA1 and BRCA2 has become integral to the care of women with a severe family history breast or ovarian cancer, but an unknown number patients receive negative (ie, wild-type) results when they actually carry pathogenic mutation. Furthermore, other cancer genes generally are not evaluated.To determine frequency types undetected cancer-predisposing BRCA1, BRCA2, CHEK2, TP53, PTEN among from high-risk families (wild-type) genetic test BRCA2.Between...
Lung cancer is mainly caused by smoking, but the quantitative relations between smoking and histologic subtypes of lung remain inconclusive. By using one largest datasets ever assembled, we explored impact on risks major cell types cancer. This pooled analysis included 13,169 cases 16,010 controls from Europe Canada. Studies with population comprised 66.5% subjects. Adenocarcinoma (AdCa) was most prevalent subtype in never smokers women. Squamous carcinoma (SqCC) predominated male smokers....
Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved susceptibility to etiologically complex disease. We conducted a GWAS identify upper aero-digestive tract (UADT) cancers. genotyping was carried out using the Illumina HumanHap300 beadchips 2,091 UADT cancer cases and 3,513 controls from two large European multi-centre studies, as well 4,821 generic controls. The 19 top-ranked variants were investigated further an additional 6,514...
The prevalence and spectrum of germline mutations in BRCA1 BRCA2 have been reported single populations, with the majority reports focused on White Europe North America. Consortium Investigators Modifiers BRCA1/2 (CIMBA) has assembled data 18,435 families 11,351 ascertained from 69 centers 49 countries six continents. This study comprehensively describes characteristics 1,650 unique 1,731 deleterious (disease-associated) identified CIMBA database. We observed substantial variation mutation...
Abstract International differences in the incidence of many cancer types indicate existence carcinogen exposures that have not yet been identified by conventional epidemiology make a substantial contribution to burden 1 . In clear cell renal carcinoma, obesity, hypertension and tobacco smoking are risk factors, but they do explain geographical variation its 2 Underlying causes can be inferred sequencing genomes cancers from populations with different rates detecting patterns somatic...