A5059388195- Congenital gastrointestinal and neural anomalies
- Congenital Anomalies and Fetal Surgery
- Pediatric Hepatobiliary Diseases and Treatments
- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- Cancer Genomics and Diagnostics
- Gastrointestinal disorders and treatments
- Renal and related cancers
- Sarcoma Diagnosis and Treatment
- Renal cell carcinoma treatment
- Esophageal and GI Pathology
- Colorectal Cancer Surgical Treatments
- Intestinal Malrotation and Obstruction Disorders
- Glioma Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Neuroblastoma Research and Treatments
- Colorectal Cancer Treatments and Studies
- Congenital Diaphragmatic Hernia Studies
- Epigenetics and DNA Methylation
- Urological Disorders and Treatments
- Pancreatic and Hepatic Oncology Research
- CAR-T cell therapy research
- Bladder and Urothelial Cancer Treatments
- Diverticular Disease and Complications
- Virus-based gene therapy research
Prince of Songkla University
2016-2025
University of Cincinnati Medical Center
2024
Wellcome Trust
2017
University of Alberta
2017
Creative Research Enterprises (United States)
2015
The Royal Melbourne Hospital
2008
Osaka University
2005-2007
Hatyai Hospital
2004
Abstract International differences in the incidence of many cancer types indicate existence carcinogen exposures that have not yet been identified by conventional epidemiology make a substantial contribution to burden 1 . In clear cell renal carcinoma, obesity, hypertension and tobacco smoking are risk factors, but they do explain geographical variation its 2 Underlying causes can be inferred sequencing genomes cancers from populations with different rates detecting patterns somatic...
Defective defecation function, also known as low anterior resection syndrome (LARS), is a common problem after surgical treatment of rectal cancer that has detrimental effect on quality life. This study aimed to look for the incidence LARS in patients whose native rectum could not be kept and determine factors influencing major LARS.Rectal who underwent tumor removal with mesorectal excision colorectal anastomosis by surgeon during years 2004-2013 were asked participate structured interview...
Although it has been suggested that the MYCN oncoprotein functions may influence tumorigenesis and patient survival in neuroblastoma, mechanism of these remains unclear. To elucidate such molecular biological mechanisms, we performed knock-down expression using RNA interference (RNAi) method. MYCN-siRNAs (MYCN-siRNA) were transfected into MYCN-amplified cell line NB-1. verify sequence specificity siRNA, prepared three control groups (siRNA group: siRNAs with no significant homology to any...
CD19 chimeric antigen receptor T (CD19CAR-T) cells have achieved promising outcomes in relapsed/refractory B cell malignancies. However, recurrences occur due to the loss of CAR-T persistence. We developed dual T/B co-stimulatory molecules (CD28 and CD40) enhance intense tumoricidal activity CD19.28.40z promoted pNF-κB pRelB downstream signaling while diminishing NFAT upon exposure. demonstrated greater proliferation, which translated into effective anti-tumor cytotoxicity long-term...
AIM:To examine the expression of beta-catenin in colorectal cancer and look for association with other clinico-pathological parameters.METHODS: Tumor samples from 163 cases (CRC) who had undergone primary colectomy between May, 1998 November, 2002 complete follow-up data either 5 years or until death were recruited a immunohistochemical study.The percentage immunoreacted tumor cells was defined as overall staining density (OSD) having nuclear localization counted (NSD).Univariate exploration...
Lactate serves as a crucial biomarker that indicates sepsis assessment in critically ill patients. A rapid, accurate, and portable analytical device for lactate detection is required. This work developed stepwise polyurethane–polyaniline–m-phenylenediamine via layer-by-layer based electrochemical biosensor, using screen-printed gold electrode determination blood samples. The biosensor was electrochemically fabricated with layers of m-phenylenediamine, polyaniline, crosslinking small amount...
Background: The study aimed to determine the incidence of K-ras and BRAF mutations in colorectal cancers (CRCs) Thai patients evaluate association with clinicopathological parameters including treatment outcomes terms event free survival (EFS). Materials Methods: Two-hundred cancer specimens were collected for studies K-Ras codon 12, 13 61, 600 by polymerase chain reaction direct nucleotide sequencing. Results: overall our was 23%. mutation frequencies CRC stages (AJCC) I, II, III IV 6.7%,...
Biliary atresia (BA) is the most severe form of obstructive cholangiopathy occurring in infants. Definitive diagnosis BA usually relies on operative findings together with supporting pathological patterns found extrahepatic bile duct. In infancy, overlapping clinical cholestasis can be other diseases including biliary hypoplasia and progressive familial intrahepatic cholestasis. addition, has been reported as a phenotype some rare genetic syndromes. Unlike BA, cholangiopathic phenotypes have...
Osteosarcoma is the most common malignant bone cancer in pediatric patients. Patients who respond poorly to chemotherapy experience worse clinical outcomes with a high mortality rate. The major challenge lack of effective drugs for these To introduce new approval, preclinical studies based on vitro models must demonstrate potency tested drugs, enabling enter phase 1 trials. Patient-derived cell culture promising testing platform studies, as they more accurately recapitulate states and...
Astrocytoma is a common type of glioma and frequent cause brain tumour-related epilepsy. Although the link between epilepsy well established, precise mechanisms underlying epileptogenesis in astrocytoma remain poorly understood. In this study, we performed proteomic analysis tissue from patients with without seizures using mass spectrometry-based techniques. We detected 131 differentially expressed proteins (42 upregulated 89 downregulated). Proteins were mostly related to an increase energy...
In this study, we conducted a comprehensive investigation into the Enterobacter cloacae complex (ECC), group of notorious pathogens responsible for various hospital-acquired infections. We aimed to gain critical insights antimicrobial resistance profiles and genomic diversity among 17 ECC isolates, which were previously collected as part short-term surveillance effort 6 months in 2019. identified two novel sequence types (ST-1936 E. bugandensis PSU30 ST-1937 roggenkampii PSU45) 14 distinct...
ABSTRACT Colorectal cancer incidence rates vary geographically and have changed over time. Notably, in the past two decades, of early-onset colorectal cancer, affecting individuals under age 50 years, has doubled many countries. The reasons for this increase are unknown. Here, we investigate whether mutational processes contribute to geographic age-related differences by examining 981 genomes from 11 No major were found microsatellite unstable cancers, but variations mutation burden...
Objective: Effective bowel preparation is crucial for a successful colonoscopy. Comparative analyses between inpatient and outpatient preparations are limited inconsistent. This study aimed to compare the outcomes of identify factors contributing suboptimal results.Material Methods: A retrospective analysis colonoscopy reports from single surgeon at provincial hospital in Thailand was conducted. Data were collected patients aged 18 or older who underwent colonoscopies July 2021 June 2023....
Mutations of β-catenin have been identified in the majority pediatric hepatic malignancies, including hepatoblastoma (HB) and hepatocellular carcinoma (HCC), suggesting its important contribution tumorigenesis this age group. However, role β-catenin/canonical Wnt signaling pathway neoplastic growth cancer cells has not directly studied. To address β-catenin's capability maintaining malignant phenotype established HB HCC cell lines, HuH-6 HepG2, harboring mutated overexpressed β-catenin, we...
Molecular subtyping of muscle-invasive bladder cancer (MIBC) predicts disease progression and treatment response. However, standard based on transcriptomic analysis is relatively expensive. This study tried to use immunohistochemistry (IHC) subtype MIBC GATA3, CK20, CK5/6, CK14 protein expression. The IHC-based subtypes in were classified as luminal (GATA3+ CK5/6-, 38.6%), basal (GATA3-CK5/6+, 12.9%), mixed CK5/6+, 37.9%), double-negative (GATA3-CK5/6-, 10.6%) 132 patients. All individual...