A5084427699- Estrogen and related hormone effects
- Genomics and Chromatin Dynamics
- Computational Drug Discovery Methods
- Gene expression and cancer classification
- Attachment and Relationship Dynamics
- Bioinformatics and Genomic Networks
- Family Dynamics and Relationships
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Cancer Cells and Metastasis
- FOXO transcription factor regulation
- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Prostate Cancer Treatment and Research
- Cancer, Lipids, and Metabolism
- Cytokine Signaling Pathways and Interactions
- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- Advanced Breast Cancer Therapies
- Molecular Biology Techniques and Applications
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Brain Metastases and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Ubiquitin and proteasome pathways
Cancer Research UK
2016-2025
University of Cambridge
2016-2025
Cancer Research UK Cambridge Center
2015-2024
Brigham Young University
2013-2024
Alzheimer’s Research UK
2020-2024
Lymphatic Education & Research Network
2023
University of Toronto
2020
University of Aberdeen
2015
Institute of Cancer Research
2015
Addenbrooke's Hospital
2015
This study examined correlates of pornography acceptance and use within a normative (nonclinical) population emerging adults (individuals aged 18—26). Participants included 813 university students (500 women; M age = 20 years) recruited from six college sites across the United States. completed online questionnaires regarding their pornography, as well sexual values activity, substance use, family formation values. Results revealed that roughly two thirds (67% ) young men one half (49%)...
We propose a fast and powerful analysis algorithm, titled Model-based Analysis of Tiling-arrays (MAT), to reliably detect regions enriched by transcription factor chromatin immunoprecipitation (ChIP) on Affymetrix tiling arrays (ChIP-chip). MAT models the baseline probe behavior considering sequence copy number each array. It standardizes value through model, eliminating need for sample normalization. uses an innovative function score ChIP enrichment, which allows robust P false discovery...
Adaptation to hypoxia is mediated through a coordinated transcriptional response driven largely by hypoxia-inducible factor 1 (HIF-1). We used ChIP-chip and gene expression profiling identify direct targets of HIF-1 transactivation on genome-wide scale. Several hundred were identified and, as expected, highly enriched for proteins that facilitate metabolic adaptation hypoxia. Surprisingly, there was also striking enrichment the family 2-oxoglutarate dioxygenases, including jumonji-domain...
Estrogen receptor-α (ER) is the driving transcription factor in most breast cancers, and its associated proteins can influence drug response, but direct methods for identifying interacting have been limited. We purified endogenous ER using an approach termed RIME (rapid immunoprecipitation mass spectrometry of proteins) discovered interactome under agonist- antagonist-liganded conditions cancer cells, revealing transcriptional networks cancer. The estrogen-enriched interactor GREB1, a...
The cohesin protein complex holds sister chromatids in dividing cells together and is essential for chromosome segregation. Recently, has been implicated mediating transcriptional insulation, via its interactions with CTCF. Here, we show different cell types that functionally behaves as a tissue-specific regulator, independent of CTCF binding. By performing matched genome-wide binding assays (ChIP-seq) human breast cancer (MCF-7), discovered thousands genomic sites share estrogen receptor...
Estrogen receptor (ESR1) drives growth in the majority of human breast cancers by binding to regulatory elements and inducing transcription events that promote tumor growth. Differences enhancer occupancy ESR1 contribute diverse expression profiles clinical outcome observed cancer patients. GATA3 is an ESR1-cooperating factor mutated tumors; however, its genomic properties are not fully defined. In order investigate composition enhancers involved estrogen-induced potential role GATA3, we...
Abstract The transcription factor GATA-3 is required for normal mammary gland development, and its expression highly correlated with estrogen receptor α (ERα) in human breast tumors. However, the functional role of ERα-positive cancers yet to be established. Here, we show that estradiol stimulation cell cycle progression cancer cells. signaling requires direct positive regulation ERα gene itself by GATA-3. binds two cis-regulatory elements located within gene, this RNA polymerase II...
Estradiol (E2) regulates gene expression at the transcriptional level by functioning as a ligand for estrogen receptor alpha (ERα) and beta (ERβ). E2-inducible proteins c-Myc E2Fs are required optimal ERα activity secondary responses, respectively. We show that E2 induces 21 microRNAs represses seven in MCF-7 breast cancer cells; these have potential to control 420 E2-regulated 757 non-E2-regulated mRNAs post-transcriptional level. The serine/threonine kinase, AKT, alters of microRNAs....