A5024538931- Estrogen and related hormone effects
- Breast Cancer Treatment Studies
- Prostate Cancer Treatment and Research
- HER2/EGFR in Cancer Research
- Advanced Breast Cancer Therapies
- Cancer Treatment and Pharmacology
- Menopause: Health Impacts and Treatments
- Cancer, Lipids, and Metabolism
- Hormonal and reproductive studies
- Breast Lesions and Carcinomas
- Cancer-related Molecular Pathways
- Cytokine Signaling Pathways and Interactions
- Phytoestrogen effects and research
- BRCA gene mutations in cancer
- Global Cancer Incidence and Screening
- Genomics and Chromatin Dynamics
- Gene expression and cancer classification
- Mechanisms of cancer metastasis
- Ubiquitin and proteasome pathways
- Mass Spectrometry Techniques and Applications
- Skin Protection and Aging
- Nutrition, Genetics, and Disease
- Cutaneous Melanoma Detection and Management
- Metastasis and carcinoma case studies
- Intestinal Malrotation and Obstruction Disorders
The University of Adelaide
2010-2025
Australian War Memorial
2018
Hanson Institute
2005-2015
Flinders Medical Centre
1996-2014
Flinders University
1993-2012
University of South Australia
1998
Marymount University
1996
Abstract There is emerging evidence that the balance between estrogen receptor-α (ERα) and androgen receptor (AR) signaling a critical determinant of growth in normal malignant breast. In this study, we assessed AR status cohort 215 invasive ductal breast carcinomas. ERα were coexpressed majority (80-90%) tumor cells. Kaplan-Meier product limit analysis multivariate Cox regression showed an independent prognostic factor ERα-positive disease, with low level (less than median 75% positive...
The androgen receptor is a tumour suppressor in oestrogen receptor-positive breast cancer. activity and safety of enobosarm, an oral selective modulator, was evaluated women with (ER)-positive, HER2-negative, (AR)-positive disease.
Breast and prostate cancer research to date has largely been predicated on the use of cell lines in vitro or vivo . These limitations have led development more clinically relevant models, such as organoids murine xenografts that utilize patient‐derived material; however, issues related low take rate, long duration establishment, associated costs constrain these models. This study demonstrates ex culture freshly resected breast tumor specimens obtained from surgery, termed explants ( PDE s),...
// Theresa E. Hickey 1, * , Connie M. Irvine Heidi Dvinge 2, 3 Gerard A. Tarulli 1 Adrienne R. Hanson Natalie K. Ryan Marie Pickering Stephen N. Birrell Dong Gui Hu 4 Peter I. Mackenzie Roslin Russell 5 Carlos Caldas Ganesh V. Raj 6 Scott Dehm 7, 8 Plymate 9 Robert Bradley Wayne D. Tilley 10 Luke Selth Dame Roma Mitchell Cancer Research Laboratories, Discipline of Medicine, The University Adelaide, SA 5005, Australia 2 Computational Biology Program, Public Health Sciences Division, Seattle,...
The cellular response to circulating sex steroids is more than the sum of individual hormone actions, instead representing an interplay between activities evolutionarily related steroid receptors. An example this interaction in breast cancer, where risk dying from estrogen receptor-α (ERα)-positive disease decreases approximately 4-fold when androgen receptor (AR) expression high. In study, we used chromatin immunoprecipitation sequencing (ChIP-seq) and microarray profiling investigate...
PURPOSE To determine the predictive value of androgen receptor (AR) levels in primary tumors women who undergo medroxyprogesterone acetate (MPA) therapy for advanced breast cancer after relapse on tamoxifen adjuvant therapy. METHODS Between 1984 and 1987 at Flinders Medical Centre, South Australia, 136 postmenopausal received lymph node-positive cancer. Estrogen (ER), progesterone (PgR), AR levels, tumor size, degree axillary node involvement were determined time diagnosis. The median...
Recent evidence indicates that the estrogen receptor-α-negative, androgen receptor (AR)-positive molecular apocrine subtype of breast cancer is driven by AR signaling. The MDA-MB-453 cell line prototypical model this subtype; its proliferation stimulated androgens such as 5α-dihydrotestosterone (DHT) but inhibited progestin medroxyprogesterone acetate (MPA) via AR-mediated mechanisms. We report here gene in cells contains a G-T transversion exon 7, resulting variant with glutamine to...
1020 Background: The AR is expressed in up to 90% of ER+ breast cancer where it acts as a tumor suppressor. Historically, therapy with synthetic androgens had efficacy, but virilizing side effects and toxicity limited their use. Enobosarm selective activating agent that does not cause masculinization has positive attributes such promotion bone improvement physical function. In phase 2 study, correlation between the degree staining antitumor activity AR+/ER+ patients metastatic (MBC) was...
Abstract Previously, we reported that androgen receptor (AR), but not estrogen (ER) or progesterone (PR), is predictive of response to the synthetic progestin, medroxyprogesterone acetate (MPA), in a cohort 83 patients with metastatic breast cancer. To further investigate role AR determining MPA this cohort, analyzed levels by immunohistochemistry two discrete antisera directed at either NH2 COOH termini receptor. Compared tumors responded (n = 31), there was significant decrease intensity...
Aims Apolipoprotein D (ApoD) is a protein that regulated by androgen and oestrogen, major constituent of breast cysts. Although ApoD has been reported to be marker cancer, its prognostic importance in invasive cancer unclear. The aim this study was investigate the relationship between expression, oestrogen receptor‐α (ERα) expression receptor (AR) predicting outcome. Methods results levels were measured use immunohistochemistry video image analysis on tissue sections from cohort ( n = 214)....
Medroxyprogesterone acetate (MPA), a component of combined estrogen-progestin therapy (EPT), has been associated with increased breast cancer risk in EPT users. MPA can bind to the androgen receptor (AR), and AR signaling inhibits cell growth tissues. Therefore, aim this study was investigate potential disrupt an ex vivo culture model normal human tissue.Histologically tissues from women undergoing surgical operation were cultured presence or absence native ligand 5α-dihydrotestosterone...