Peter A. Kanetsky
A5083663241- Cutaneous Melanoma Detection and Management
- Skin Protection and Aging
- melanin and skin pigmentation
- Testicular diseases and treatments
- Melanoma and MAPK Pathways
- BRCA gene mutations in cancer
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Epigenetics and DNA Methylation
- Vitamin D Research Studies
- Genetic Associations and Epidemiology
- Nutrition, Genetics, and Disease
- LGBTQ Health, Identity, and Policy
- Sexual Differentiation and Disorders
- Climate Change Communication and Perception
- Allergic Rhinitis and Sensitization
- Biochemical Analysis and Sensing Techniques
- Glutathione Transferases and Polymorphisms
- Cervical Cancer and HPV Research
- Behavioral Health and Interventions
- Mast cells and histamine
- CAR-T cell therapy research
- Computational Drug Discovery Methods
Moffitt Cancer Center
2016-2025
University of Wisconsin–Madison
2023
University of Pennsylvania
2006-2021
Philadelphia University
2021
University of South Florida
2015-2018
National Institutes of Health
2006-2017
Memorial Sloan Kettering Cancer Center
1992-2016
The University of Sydney
2010-2016
Women's College Hospital
2013-2016
University of North Carolina at Chapel Hill
2016
Increased risk of mortality in patients with CKD has been attributed to inflammation. However, the association between kidney function, albuminuria, and biomarkers inflammation not examined a large cohort patients.This study measured plasma levels IL-1β, IL-1 receptor antagonist (IL-1RA), IL-6, TNF-α, TGF-β, high-sensitivity C-reactive protein (hs-CRP), fibrinogen, serum albumin 3939 participants enrolled Chronic Renal Insufficiency Cohort June 2003 September 2008. An score was established...
Background and objectives CKD is a global public health problem with significant mortality morbidity. Design, setting, participants, & measurements We examined the multivariable association of plasma levels IL-1, IL-1 receptor antagonist, IL-6, TNF- α , TGF- β high–sensitivity C–reactive protein, fibrinogen, serum albumin progression in 3430 Chronic Renal Insufficiency Cohort study participants. Results Over median follow-up time 6.3 years, 899 participants reached composite end point...
Germline variants in MC1R, the gene encoding melanocortin-1 receptor, and sun exposure increase risk for melanoma Caucasians. The majority of melanomas that occur on skin with little evidence chronic sun-induced damage (non-CSD melanoma) have mutations BRAF oncogene, whereas marked CSD (CSD these are less frequent. In two independent Caucasian populations, we show MC1R strongly associated non-CSD melanomas. this tumor subtype, is due to an developing mutations.
<h3>Importance</h3>This study proposes an alternative tumor staging system for cutaneous squamous cell carcinoma (CSCC) that more precisely defines the small subset of tumors with a high risk metastasis and death.<h3>Objective</h3>To identify factors poor outcomes in CSCC evaluate 2010 American Joint Committee on Cancer (AJCC) (T) system's ability to stratify occurrence these outcomes.<h3>Design</h3>Retrospective cohort study.<h3>Setting</h3>A single academic...
Although most hospital-based studies suggest more favorable survival with tumor-infiltrating lymphocytes (TILs) present in primary melanomas, it is uncertain whether TILs provide prognostic information beyond existing melanoma staging definitions. We addressed the issue an international population-based study of patients single and multiple melanomas.On basis Genes, Environment Melanoma (GEM) study, we conducted follow-up 2,845 diagnosed from 1998 to 2003 3,330 invasive melanomas centrally...
Abstract In cancer patients, a high pre-treatment neutrophil-to-lymphocyte ratio (NLR) is associated with poorer survival outcomes. Significant variation in the magnitude of this association has been observed between studies, but sources are poorly understood. Here, we explore differences prognostic potential NLR patient subgroups stratified by demographic and clinical characteristics using retrospective cohort 5,363 patients treated at Moffitt Cancer Center (Tampa, FL). We identify for whom...
Melanoma risk is related to sun exposure; we have investigated variation by tumour site and latitude.We performed a pooled analysis of 15 case-control studies (5700 melanoma cases 7216 controls), correlating patterns exposure, sunburn solar keratoses (three studies) with risk. Pooled odds ratios (pORs) 95% Bayesian confidence intervals (CIs) were estimated using unconditional polytomous logistic random-coefficients models.Recreational exposure was factor for on the trunk (pOR = 1.7; CI:...
NRAS and BRAF mutations in melanoma inform current treatment paradigms, but their role survival from primary has not been established. Identification of patients at high risk melanoma-related death based on characteristics before evidence recurrence could recommendations for patient follow-up eligibility adjuvant trials.
IMPORTANCE Previous studies have reported that histopathologically amelanotic melanoma is associated with poorer survival than pigmented melanoma; however, small numbers of melanomas, selected populations, lack centralized pathologic review, or no adjustment for stage limit the interpretation generalization results from prior studies.OBJECTIVE To compare melanoma-specific between patients and those in a large international population-based study.DESIGN, SETTING, AND PARTICIPANTS Survival...
Purpose.: Somatic mutations in GNAQ, GNA11, SF3B1, EIF1AX, and BAP1 have been identified uveal melanoma (UM). The aim of this study was to determine whether these genes primary tumors were associated with metastases individuals diagnosed UM. Methods.: A total 63 UM cases who developed a metastasis within 48 months treatment 53 controls metastasis-free over similar time period selected for the study. Primary screened BAP1. association tumor characteristics, chromosome 3 copy number,...
Susceptibility to testicular germ cell tumors (TGCT) has a significant heritable component, and genome-wide association studies (GWASs) have identified with variants in several genes, including KITLG , SPRY4 BAK1 TERT DMRT1 ATF7IP . In our GWAS, we genotyped 349 TGCT cases 919 controls replicated top hits an independent set of 439 960 attempt find novel susceptibility loci. We second marker (rs7040024) the doublesex mab-3-related transcription factor 1 ( ) gene that is previously described...
PURPOSE To identify potential gaps in attitudes, knowledge, and institutional practices toward lesbian, gay, bisexual, transgender, queer/questioning (LGBTQ) patients, a national survey of oncologists at National Cancer Institute–Designated Comprehensive Centers was conducted to measure these attributes related LGBTQ patients desire for future training education. METHODS A random sample 450 from 45 cancer centers selected the American Medical Association’s Physician Masterfile complete...
The MC1R gene is a key regulator of skin pigmentation. We aimed to evaluate the association between variants and risk sporadic cutaneous melanoma (CM) within M‐SKIP project, an international pooled‐analysis on , cancer phenotypic characteristics. Data included 5,160 cases 12,119 controls from 17 studies. calculated summary odds ratio (SOR) for each nine most studied combined with CM by using random‐effects models. Stratified analysis characteristics were also performed. Melanoma increased...
Abstract Genome-wide association studies (GWAS) have led to the identification of hundreds susceptibility loci across cancers, but impact further remains uncertain. Here we analyse summary-level data from GWAS European ancestry fourteen cancer sites estimate number common variants (polygenicity) and underlying effect-size distribution. All cancers show a high degree polygenicity, involving at minimum thousands loci. We project that sample sizes required explain 80% heritability vary 60,000...