Parichoy Pal Choudhury
A5058566452- Global Cancer Incidence and Screening
- BRCA gene mutations in cancer
- Genetic Associations and Epidemiology
- Cancer Risks and Factors
- Health, Environment, Cognitive Aging
- Nutrition, Genetics, and Disease
- Breast Cancer Treatment Studies
- Cardiovascular Health and Risk Factors
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Lung Cancer Treatments and Mutations
- Statistical Methods in Clinical Trials
- Cancer Genomics and Diagnostics
- Research Data Management Practices
- Bladder and Urothelial Cancer Treatments
- Advanced Causal Inference Techniques
- Artificial Intelligence in Healthcare
- Statistical Methods and Inference
- Colorectal Cancer Screening and Detection
- Economic and Financial Impacts of Cancer
- Adipose Tissue and Metabolism
- Security in Wireless Sensor Networks
- RNA modifications and cancer
- DNA Repair Mechanisms
- Frailty in Older Adults
American Cancer Society
2023-2025
Division of Cancer Epidemiology and Genetics
2019-2024
National Cancer Institute
2019-2024
National Institutes of Health
2020-2023
Johns Hopkins University
2016-2021
Government of the United States of America
2021
Cancer Research UK
2020
Montserrat Volcano Observatory
2020
University of North Carolina at Chapel Hill
2020
University of Cambridge
2020
Abstract Genome-wide association studies (GWAS) have led to the identification of hundreds susceptibility loci across cancers, but impact further remains uncertain. Here we analyse summary-level data from GWAS European ancestry fourteen cancer sites estimate number common variants (polygenicity) and underlying effect-size distribution. All cancers show a high degree polygenicity, involving at minimum thousands loci. We project that sample sizes required explain 80% heritability vary 60,000...
This report describes an R package, called the Individualized Coherent Absolute Risk Estimator (iCARE) tool, that allows researchers to build and evaluate models for absolute risk apply them estimate individual’s of developing disease during a specified time interval based on set user defined input parameters. An attractive feature software is it gives users flexibility update rapidly new knowledge factors tailor different populations by specifying three arguments: model relative risk,...
Abstract Background External validation of risk models is critical for risk-stratified breast cancer prevention. We used the Individualized Coherent Absolute Risk Estimation (iCARE) as a flexible tool model development and comparative to make projections population stratification. Methods Performance two recently developed models, one based on Breast Prostate Cancer Cohort Consortium analysis (iCARE-BPC3) another literature review (iCARE-Lit), were compared with established (Breast...
Abstract Background The Breast and Ovarian Analysis of Disease Incidence Carrier Estimation Algorithm (BOADICEA) the Tyrer-Cuzick breast cancer risk prediction models are commonly used in clinical practice have recently been extended to include polygenic scores (PRS). In addition, BOADICEA has also reproductive lifestyle factors, which were already part model. We conducted a comparative prospective validation these after incorporating developed 313-variant PRS. Methods Calibration...
Rigorous evaluation of the calibration and discrimination breast-cancer risk-prediction models in prospective cohorts is critical for applications under clinical guidelines. We comprehensively evaluated an integrated model incorporating classical risk factors a 313-variant polygenic score (PRS) to predict risk.Fifteen from six countries with 239 340 women (7646 incident cases) European ancestry aged 19-75 years were included. Calibration 5-year was assessed by comparing expected observed...
Lung cancer mortality rates in the United States have declined steeply recent decades, largely because of substantial reductions smoking prevalence, as approximately 85% lung deaths are attributable to cigarette smoking. In this study, authors estimate number averted and corresponding person-years life gained during 1970-2022 a measure progress prevention through tobacco control. By using National Center for Health Statistics data (with national coverage), calculated expected each year, age,...
We evaluated the joint associations between a new 313-variant PRS (PRS313) and questionnaire-based breast cancer risk factors for women of European ancestry, using 72 284 cases 80 354 controls from Breast Cancer Association Consortium. Interactions were standard logistic regression newly developed case-only method overall by estrogen receptor status. After accounting multiple testing, we did not find evidence that per-standard deviation PRS313 odds ratio differed across strata defined...
Abstract Data sharing is essential for reproducibility of epidemiologic research, replication findings, pooled analyses in consortia efforts, and maximizing study value to address multiple research questions. However, barriers related confidentiality, costs, incentives often limit the extent speed data sharing. Epidemiological practices that follow Findable, Accessible, Interoperable, Reusable (FAIR) principles can these by making resources findable with necessary metadata, accessible...
Abstract Background. The etiology of second primary cancers among survivors older adult-onset is largely known. There limited data as to whether genetic predisposition increases the risk cancer survivors. Methods. This analysis was conducted men and women enrolled in Cancer Prevention Study II Nutrition cohort who were diagnosed with a first non-metastatic incident between 1992 2015. Survivors followed-up until 2017 for diagnosis at different organ. Analyses restricted participants data,...
Abstract There is limited knowledge of the sociodemographic characteristics individuals who are fully adherent to all recommended cancer screening tests. Understanding these gaps may provide insights into subpopulations benefit from interventions increase overall early detection. The Cancer Prevention Study- 3 a prospective cohort study established by American Society (enrollment 2006-2013). Between enrollment and 2018, cancer-free participants reported tests (mammography, colonoscopy,...
Objectives Evidence suggests vitamin D deficiency is associated with developing frailty. However, cardiometabolic factors are related to both conditions and may confound and/or mediate the D–frailty association. We aimed determine association of concentration incidence frailty, role diseases (cardiovascular disease, diabetes, hyperlipidemia, hypertension) in this relationship. Design Prospective longitudinal cohort study (7 visits from 1994–2008). Setting Baltimore, Maryland. Participants...
Abstract Background: Risk estimates for women carrying germline mutations in breast cancer susceptibility genes are mainly based on studies of European ancestry women. Methods: We investigated associations between pathogenic variants (PV) 34 with risk 871 cases [307 estrogen receptor (ER)-positive, 321 ER-negative, and 243 ER-unknown] 1,563 controls the Ghana Breast Health Study (GBHS), estimated lifetime carriers. compared results those European, Asian, African American Results: The...
Abstract Introduction Community health centers (CHCs) provide historically marginalized populations with primary care, including cancer screening. Previous studies have reported that women living in rural areas are less likely to be up date cervical screening than urban areas. However, little is known about rural–urban differences CHCs and the contributing factors, whether such changed during COVID‐19 pandemic. Methods Using 8‐year pooled Uniform Data System (2014‐2021) data Oaxaca‐Blinder...
Estimating absolute risk of lung cancer for never-smoking individuals is important to inform screening programs.
Interleukin 10tm1Cgn (IL 10tm) mice have been utilized as a model of chronic inflammation and declining health span because their propensity to develop activation in NFkB pathways, skeletal muscle cardiac changes, mitochondrial dysfunction. We hypothesized that older IL 10tm frail would alterations similar frail, humans measured parameters glucose metabolism, oxygen consumption (VO2), respiratory quotient (RQ), spontaneous locomotor activity, body composition plasma adipokine levels. To test...
Abstract We analyzed summary-level data from genome-wide association studies (GWAS) of European ancestry across fourteen cancer sites to estimate the number common susceptibility variants (polygenicity) contributing risk, as well distribution their associated effect sizes. All cancers evaluated showed polygenicity, involving at a minimum thousands independent variants. For some malignancies, particularly chronic lymphoid leukemia (CLL) and testicular cancer, there are larger proportion with...
Abstract Ovarian cancer is a rare and highly heterogeneous disease usually detected at late stages when outcomes are poor. Population-based screening approaches have not been successful reducing ovarian mortality, but preventive bilateral salpingo-oophorectomy effective preventing in high-risk populations. risk prediction models may allow identification of populations increased for interventions or targeted early detection. We propose life-course approach to based on the time which model...
Abstract This report describes a R package, called the Individualized Coherent Absolute Risk Estimation ( iCARE ) tool, that allows researchers to build and evaluate models for absolute risk apply them estimate an individual’s of developing disease during specified time interval based on set user defined input parameters. An attractive feature software is it gives users flexibility update rapidly new knowledge factors tailor different populations by specifying three arguments: (1) model...
Abstract Background Well-validated risk models are critical for stratified breast cancer prevention. We used the Individualized Coherent Absolute Risk Estimation (iCARE) tool comparative model validation of five-year invasive in a prospective cohort, and to make projections population stratification. Methods Performance two recently developed models, iCARE-BPC3 iCARE-Lit, were compared with established (BCRAT, IBIS) based on classical factors UK-based cohort 64,874 women (863 cases) aged...
Independent validation of risk prediction models in prospective cohorts is required for risk-stratified cancer prevention. Such studies often have a two-phase design, where information on expensive biomarkers are ascertained nested substudy the original cohort.We propose simple approach evaluating model discrimination that accounts incomplete follow-up and gains efficiency by using data from all individuals cohort irrespective whether they were sampled substudy. For AUC, we estimated...