Ali Sahimi
A5011001110- Amyotrophic Lateral Sclerosis Research
- Genetic Associations and Epidemiology
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Neurogenetic and Muscular Disorders Research
- Prion Diseases and Protein Misfolding
- biodegradable polymer synthesis and properties
- Molecular Biology Techniques and Applications
- Cholinesterase and Neurodegenerative Diseases
- Race, Genetics, and Society
- Cancer-related molecular mechanisms research
- Parkinson's Disease Mechanisms and Treatments
- Neurological diseases and metabolism
- Protein Structure and Dynamics
- Inflammatory Biomarkers in Disease Prognosis
- Extracellular vesicles in disease
New York University
2025
University of Southern California
2019-2023
Broad Center
2019
Abstract Background: Polygenic risk scores (PRS) could effectively identify individuals at higher of prostate cancer (PCa) and may have notable implications for screening. However, PRS classification depends on the comparison population. Objective: We investigated how different reference populations methods defining categories affect interpretation. Methods: evaluated a multi-ancestry PCa in 6, 194 cases 24, 693 controls from self-identified non-Hispanic White (WH), African American (AA),...
Abstract The most common known cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is a hexanucleotide repeat expansion (HRE) in C9ORF72 that contributes to neurodegeneration by both loss-of-function (decreased protein levels) gain-of-function (e.g. dipeptide production) mechanisms. Although therapeutics targeting the mechanisms are clinical development, it unclear if these will be efficacious given contribution processes neurodegeneration. Moreover, there lack...
Tumor-educated platelets (TEPs) are a potential method of liquid biopsy for the diagnosis and monitoring cancer. However, mechanism underlying tumor education is not known, transcripts associated with TEPs often tumor-associated transcripts. We demonstrated that direct transfer to circulating an unlikely source TEP signal. used CDSeq, latent Dirichlet allocation algorithm, deconvolute signal in blood samples from patients glioblastoma. substantial proportion platelet transcriptome derived...
Poly-glycine-alanine (poly-GA) proteins are widely believed to be one of the main toxic dipeptide repeat molecules associated with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia diseases. Using discontinuous molecular dynamics simulation an all-atom model proteins, we study folding, stability, aggregation poly-GA. The results demonstrate that poly-GA is aggregation-prone protein that, after a long enough time, forms β-sheet-rich aggregates match recent experiment data two...
We propose a machine learning (ML) method to classify ALS–causative and non–ALS–causative variants based on 24 variables in five different datasets. The proposed ML classifies the datasets with very high accuracy. In particular, it predicts ALS 100 percent accuracy, while its accuracy for non-ALS is up 99.31 percent. trained classifier also identifies nine most influencial mutation assessors that help distinguishing two classes from each other. They are FATHMM_score, PROVEAN_score,...