Artitaya Lophatananon
A5075695781- BRCA gene mutations in cancer
- Genetic Associations and Epidemiology
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Nutrition, Genetics, and Disease
- Global Cancer Incidence and Screening
- Genetic factors in colorectal cancer
- Cancer Risks and Factors
- Gene expression and cancer classification
- Estrogen and related hormone effects
- Molecular Biology Techniques and Applications
- Cancer Genomics and Diagnostics
- Bladder and Urothelial Cancer Treatments
- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- Endometrial and Cervical Cancer Treatments
- Bioinformatics and Genomic Networks
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Health, Environment, Cognitive Aging
- Health Systems, Economic Evaluations, Quality of Life
- CRISPR and Genetic Engineering
- Pancreatic and Hepatic Oncology Research
- Genomics and Rare Diseases
Manchester Academic Health Science Centre
2013-2025
University of Manchester
2016-2025
Milliman (United States)
2021-2023
Manado State University
2021-2023
University of Warwick
2011-2022
University of Wisconsin–Madison
2022
Primary Health Care
2019-2021
St Mary's Hospital
2021
Edinburgh Cancer Research
2021
Cancer Research Center
2021
Rare germline genetic variants in several genes are associated with increased breast cancer (BC) risk, but their precise contributions to different disease subtypes unclear. This information is relevant guidelines for gene panel testing and risk prediction.To characterize tumors BC susceptibility large-scale population- or hospital-based studies.The multicenter, international case-control analysis of the BRIDGES study included 42 680 patients 46 387 control participants, comprising women...
Polygenic risk scores (PRS) have been shown to predict breast cancer in European women, but their utility Asian women is unclear. Here we evaluate the best performing PRSs for European-ancestry using data from 17,262 cases and 17,695 controls of ancestry 13 case-control studies, 10,255 Chinese a prospective cohort (413 incident cancers). Compared middle quintile distribution, highest 1% PRS distribution ~2.7-fold lowest has ~0.4-fold developing cancer. There no evidence heterogeneity...
Background Various risk factors have been associated with epithelial ovarian cancer in observational epidemiological studies. However, the causal nature of reported, and thus their suitability as effective intervention targets, is unclear given susceptibility conventional designs to residual confounding reverse causation. Mendelian randomization (MR) uses genetic variants proxies for strengthen inference We used MR evaluate association 12 previously reported (reproductive, anthropometric,...
Protein truncating variants in ATM, BRCA1, BRCA2, CHEK2, and PALB2 are associated with increased breast cancer risk, but risks missense these genes uncertain. We analyzed data on 59,639 cases 53,165 controls from studies participating the Breast Cancer Association Consortium BRIDGES project. sampled training (80%) validation (20%) sets to analyze rare ATM (1146 variants), BRCA1 (644), BRCA2 (1425), CHEK2 (325), (472). evaluated according five silico prediction-of-deleteriousness algorithms,...
Breast cancer risks conferred by many germline missense variants in the
Genome-wide association studies (GWASs) have revealed increased breast cancer risk associated with multiple genetic variants at 5p12. Here, we report the fine mapping of this locus using data from 104,660 subjects 50 case-control in Breast Cancer Association Consortium (BCAC). With for 3,365 genotyped and imputed SNPs across a 1 Mb region (positions 44,394,495–45,364,167; NCBI build 37), found evidence least three independent signals: strongest signal, consisting single SNP rs10941679, was...
Introduction Over 80% of the nearly 1 million men diagnosed with prostate cancer annually worldwide present localised or locally advanced non-metastatic disease. Risk stratification is cornerstone for clinical decision making and treatment selection these men. The most widely applied systems use presenting prostate-specific antigen (PSA) concentration, biopsy Gleason grade, stage to classify patients as low, intermediate, high risk. There is, however, significant heterogeneity in outcomes...
Non-European populations are under-represented in genetics studies, hindering clinical implementation of breast cancer polygenic risk scores (PRSs). We aimed to develop PRSs using the largest available studies Asian ancestry and assess transferability PRS across ethnic subgroups.
Objectives To investigate the association between shingles and dementia, Zostavax vaccination dementia. Design Nested case–control study. Settings Data were drawn from UK Biobank cohort study with a total of 228 223 participants Hospital Episodes Statistics primary care linkage health records. Participants The analyses included 2378 incident dementia cases 225 845 controls. Inclusion criteria for diagnosis 3 years or more after first assessment date derived all sources including...
Abstract Background Dementia affects ability to remember, think, or make decisions that interfere with doing everyday activities. There is no cure, therefore any prevention delay of the onset importance. This study aims investigate association between zoster and influenza vaccinations risk developing dementia. Methods We conducted a retrospective population-based cohort using electronic health records from 1469 general practices contributing Clinical Practice Research Datalink (CPRD) Aurum...
Abstract Background DNA methylation plays a critical role in breast cancer development. Previous studies have identified marks white blood cells as promising biomarkers for cancer. However, these were limited by low statistical power and potential biases. Using new methodology, we investigated their associations with risk. Methods Statistical models built to predict levels of using genetic data from HumanMethylation450 BeadChip the Framingham Heart Study (n = 1595). The prediction validated...
The purpose of this study is to validate a new five-tiered prognostic classification system better discriminate cancer-specific mortality in men diagnosed with primary non-metastatic prostate cancer. We applied recently described five-strata model, the Cambridge Prognostic Groups (CPGs 1-5), two international cohorts and tested performance against current standard three-strata low-, intermediate- or high-risk disease. Diagnostic clinico-pathological data for obtained from Prostate Cancer...
Previous studies have shown that reproductive factors are differentially associated with breast cancer (BC) risk by subtypes. The aim of this study was to investigate associations between and BC subtypes, whether these vary age at diagnosis. We used pooled data on tumor markers (estrogen progesterone receptor, human epidermal growth factor receptor-2 (HER2)) (parity, first full-time pregnancy (FFTP) menarche) from 28,095 patients invasive 34 participating in the Breast Cancer Association...
This study was designed to investigate the relationship between a systematic inflammatory biomarker measure, concurrent and later cognitive performance, future dementia risk. The literature has reported potential involvement of inflammation in performance as well Alzheimer’s Disease, but not consistently. We used population-based cohort 500,000 people UK assessed association composite measures across five domains measured concurrently 4–13 years later, taking advantage large sample size....
Meningiomas account for up to 37% of all primary brain tumors. Genetic susceptibility meningioma is well established, with the risk among relatives patients being approximately threefold higher than that in general population. A relationship between and exposure ionizing radiation also known led us examine whether variants DNA repair genes contribute disease susceptibility.We analyzed 1127 tagging single-nucleotide polymorphisms (SNPs) were selected capture most common variation 136 five...
Genetic variation at the TERT-CLPTM1L locus 5p15.33 is associated with susceptibility to several cancers, including epithelial ovarian cancer (EOC). We have carried out fine-mapping of this region in EOC which implicates an association a single nucleotide polymorphism (SNP) within TERT promoter. demonstrate that minor alleles rs2736109, and additional promoter SNP, rs2736108, are decreased breast risk, combination both SNPs substantially reduces activity.
Abstract Introduction We have previously shown that a tag single nucleotide polymorphism (rs10235235), which maps to the CYP3A locus (7q22.1), was associated with reduction in premenopausal urinary estrone glucuronide levels and modest risk of breast cancer women age ≤50 years. Methods further investigated association rs10235235 large case control study 47,346 cases 47,570 controls from 52 studies participating Breast Cancer Association Consortium. Genotyping conducted using custom Illumina...
Background Anthropometric and reproductive factors have been reported as being established risk for breast cancer (BC). This study explores the contribution of anthropometric in UK females developing BC a large longitudinal cohort. Methods Data from Biobank prospective 273,467 were analyzed. Relative risks (RRs) 95% confidence intervals (CIs) each factor adjusted age, family history deprivation score. The analyses stratified by menopausal status. Results Over 9 years follow up total number...