A5016676462- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Prostate Cancer Treatment and Research
- Advanced biosensing and bioanalysis techniques
- Salivary Gland Tumors Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Acute Myeloid Leukemia Research
- Cleft Lip and Palate Research
- Craniofacial Disorders and Treatments
- Cancer-related molecular mechanisms research
- Tracheal and airway disorders
- Cancer Cells and Metastasis
- Chromatin Remodeling and Cancer
- Meningioma and schwannoma management
- Mechanisms of cancer metastasis
- BRCA gene mutations in cancer
- Hemoglobinopathies and Related Disorders
- Prostate Cancer Diagnosis and Treatment
- Genetic Associations and Epidemiology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
University of Southern California
2021-2023
USC Norris Comprehensive Cancer Center
2019
Objective: Comprehensive molecular profiling of radioresistant and cystic vestibular schwannoma (VS) subtypes. Study Design: Our study utilized whole-exome sequencing (WES), RNA-sequencing (RNAseq), correlated clinical data from 12 samples (2 solid sporadic subtype, 8 with changes, 2 previously irradiated). Setting: Academic medical center. Patients: Patients diagnosed VS who required surgical treatment. Inclusion: Cystic tumors matched to age tumor volume, as control; Exclusion: NF-2...
Transcriptomic profiling of metastatic cancer can illuminate mechanisms progression and lead to new therapies, but standard biopsy is invasive reflects only a single site. In contrast, circulating tumor cell (CTC) noninvasive repeatable, reflecting the dynamic systemic nature advanced disease. To date, transcriptomic CTCs has not delivered on its full potential, because white blood cells (WBCs) vastly outnumber CTCs. Current strategies either lack sensitivity specificity or require...
Triple negative breast cancer (TNBC) is an aggressive subtype that disproportionately affects women of African ancestry (WAA) and often associated with poor survival. Although there a high prevalence TNBC across West Africa in the diaspora, has been no comprehensive genomics study to investigate mutational profile ancestrally related Caribbean Africa.This multisite cross-sectional used 31 formalin-fixed paraffin-embedded (FFPE) samples from Barbadian Nigerian participants. High-resolution...
Abstract Little is known regarding the potential relationship between clonal hematopoiesis (CH) of indeterminate (CHIP), which expansion hematopoietic stem cells with somatic mutations, and risk prostate cancer, fifth leading cause cancer death men worldwide. We evaluated association age-related CHIP overall aggressive in two large whole-exome sequencing studies 75 047 European ancestry men, including 7663 cases, 2770 had disease, 3266 carrying variants. found that CHIP, defined by over 50...
Background: Orofacial clefts (OFCs) are common congenital disabilities that can occur as isolated non-syndromic events or part of Mendelian syndromes. OFC risk factors vary due to differences in regional environmental exposures, genetic variants, and ethnicities. In recent years, significant progress has been made understanding OFCs, advances sequencing genotyping technologies. Despite these advances, very little is known about the interplay Malagasy population. Methods: Here, we performed...
Abstract Clonal hematopoiesis of indeterminate potential (CHIP) has been associated with inflammation, which is a risk factor for cancer, including prostate cancer. We previously reported weak evidence an association between CHIP and cancer in men European ancestry. However, little known African ancestry populations. investigated the age-related overall aggressive large whole-exome sequencing study 12,049 men, 7,176 cases (of 3,283 had disease 1,074 metastatic disease) 4,873 controls....
Abstract Women of African ancestry (WAA) are disproportionately affected by the aggressive triple negative breast cancer (TNBC) subtype that is often associated with high recurrence rates and metastasis. Although there a prevalence TNBC across West Africa in women diaspora, has been no comprehensive genomics study to investigate mutational profile ancestrally related Caribbean Africa. To shed more light on this phenomenon, whole exome sequencing (WES) was performed 31 formalin-fixed...
Abstract Background: Prostate cancer (PCa) is the leading cause of death among Nigerian men, with most men presenting late and high grade disease. Furthermore, improved PCa diagnosis treatment could rely on genomics-driven precision approaches. Mounting evidence supports potential population enriched molecular features cancer, however extent which hampered due to a dearth genomic data in diverse cohorts. This study, therefore, aims at utilizing transcriptomics analysis deduce transcriptional...