A5061397712- Mechanisms of cancer metastasis
- Cancer Mechanisms and Therapy
- Cancer-related Molecular Pathways
- Peptidase Inhibition and Analysis
- Metastasis and carcinoma case studies
- PI3K/AKT/mTOR signaling in cancer
- Cancer and Skin Lesions
- Vitamin D Research Studies
- Advanced biosensing and bioanalysis techniques
- HER2/EGFR in Cancer Research
- Retinoids in leukemia and cellular processes
- Chromatin Remodeling and Cancer
- Epigenetics and DNA Methylation
- DNA Repair Mechanisms
- Ferrocene Chemistry and Applications
- Advanced Breast Cancer Therapies
- Mitochondrial Function and Pathology
- Hemostasis and retained surgical items
- Protein Kinase Regulation and GTPase Signaling
- Microtubule and mitosis dynamics
- Ubiquitin and proteasome pathways
- Cutaneous Melanoma Detection and Management
- Cancer, Hypoxia, and Metabolism
- MXene and MAX Phase Materials
- Bone Tissue Engineering Materials
Eli Lilly (United States)
2025
University of Maryland, Baltimore
2014-2021
University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center
2017-2018
Cliniques Universitaires Saint-Luc
2018
U-M Rogel Cancer Center
2017
Wright State University
2009-2015
Boonton Public Schools
2013-2014
Dayton Clinical Oncology Program
2013
Wound healing is a complex, multistep process that can be summarized into three stages, namely, hemostasis and inflammation, proliferation, finally, tissue remodeling. Battlefield wound demands rapid using clotting or cauterizing agents to immediately limit blood loss, but this occurs at the expense of proper repair beyond hemostasis. Layered silicate clays such as kaolin montmorillonite (MMT) have been previously shown induce due their ability form charged interactions with factors. The...
Abstract KRAS is altered in ∼16% of all cancers and an oncogenic driver NSCLC, pancreatic, colorectal, other cancers. Next generation inhibitors, designed to target multiple mutations, have the potential improve outcomes for large burden KRAS-mutated disease. Importantly, preclinical data suggest that a pan-KRAS approach spares wildtype HRAS NRAS may avoid skin toxicities associated with pan-RAS inhibition.1 This particularly important context treating colorectal cancer combination EGFR...
Loss of the tumor suppressor PTEN is observed in many human cancers that display increased chromosome instability and aneuploidy. The subcellular fractions are associated with different functions regulate cell growth, invasion stability. In this study, we show a novel role for regulating mitotic centrosomes. localization at centrosomes peaks between prophase metaphase, paralleling centrosomal PLK-1 γ-tubulin coinciding time frame centrosome maturation. primary keratinocytes, knockdown...
Background: People with Huntington’s disease (HD) have been observed to lower rates of cancers. Objective: To investigate the relationship between age onset HD, CAG repeat length, and cancer diagnosis. Methods: Data were obtained from European network REGISTRY study for 6540 subjects. Population incidence was ascertained GLOBOCAN database obtain standardised ratios cancers in Results: 173/6528 HD subjects had a The age-standardised rate all population 0.26 (CI 0.22–0.30). Individual showed...
Abstract Melanoma is a lethal skin cancer prone to progression and metastasis, resistant therapy. Metastasis therapy resistance of melanoma other cancers are driven by tumor cell plasticity, largely via acquisition/loss stem-like characteristics transitions between epithelial mesenchymal phenotypes (EMT/MET). NME1 metastasis suppressor gene that inhibits metastatic potential when its expression enforced in cancers. Herein, we have unmasked novel role for as driver growth distinct from...
The p63 transcription factor has a pivotal role in epithelial morphogenesis. Multiple transcripts of the TP63 gene are generated because alternative promoter usage and splicing. ΔNp63α is predominant isoform observed during morphogenesis human cancers. Loss expression been shown to promote invasiveness subset cancer cell lines. Here, we studied whether regulation VDR by controls an epidermoid line. We demonstrate that induced all isoforms, including ΔNp63α. Endogenous protein was bind...
1α, 25-dihydroxyvitamin D3 (VD3), a secosteriod that has been explored as an anti-cancer agent, was also shown to promote cell survival. Its receptor, the Vitamin D Receptor (VDR), is direct target of proto-oncogene ΔNp63α, which overexpressed in non-melanoma skin cancers. The interconnection between VDR/VD3 signaling and led us examine whether promotes keratinocyte proliferation by regulating ΔNp63α levels. Our data demonstrate VDR regulates expression at both transcript protein level....
Abstract Expression of the metastasis suppressor NME 1 in melanoma is associated with reduced cellular motility and invasion vitro vivo , but underlying molecular mechanisms are not completely understood. Herein, we report a novel mechanism through which controls cell morphology via upregulation extracellular matrix ( ECM ) protein fibronectin. strongly suppressed lines 1205 LU M14. The resulting sedentary phenotype was more flattened appearance marked increases actin stress fibre focal...
Abstract NME1 is a metastasis-suppressor gene (MSG), capable of suppressing metastatic activity in cell lines melanoma, breast carcinoma and other cancer origins without affecting their growth culture or as primary tumours. Herein, we selectively ablated the tandemly arranged Nme1 Nme2 genes to assess individual impacts on mouse model (HGF:p16 −/− ) ultraviolet radiation (UVR)-induced melanoma. Metastatic was strongly enhanced both genders Nme1- -null mice, with stronger females across all...
Background/Aim: NME/NM23 nucleoside diphosphate kinase 1 (NME1) is a metastasis suppressor gene, exhibiting reduced expression in metastatic cancers and the ability to suppress activity of cancer cells. We previously identified NME1-regulated genes with prognostic value human melanoma. This study was conducted melanoma cell lines aiming elucidate mechanism through which NME regulates one these genes, aldolase C (ALDOC). Materials Methods: ALDOC mRNA protein measured using qRT-PCR immunoblot...
ΔNp63α, a proto-oncogene, is up-regulated in non-melanoma skin cancers and directly regulates the expression of both Vitamin D receptor (VDR) phosphatase tensin homologue deleted on chromosome ten (PTEN). Since ΔNp63α has been shown to inhibit cell invasion via regulation VDR, we wanted determine whether dietary D3 protected against UVB induced tumor formation SKH-1 mice, model for squamous carcinoma development. We examined there was correlation between VDR or PTEN vivo mice chronically...
Reduced NME1 expression in melanoma cell lines, mouse models of melanoma, and specimens human patients is associated with increased metastatic activity. Herein, we investigate the role repair double-stranded breaks (DSBs) choice double-strand break (DSBR) pathways cells. Using chromatin immunoprecipitation, was shown to be recruited rapidly directly DSBs generated by homing endonuclease I-PpoI. within 30 min, concert recruitment ataxia-telangiectasia mutated (ATM) protein, an early step DSBR...
Pigmented epithelioid melanocytoma (PEM) is a tumor encompassing blue nevus of Carney complex (EBN CNC) and was previously termed animal-type melanoma. Histologically PEMs are heavily pigmented spindled dermal melanocytic tumors with infiltrative borders, however, their origin remains unclear. Stem cells for the epidermis hair follicle located in bulge area potential to differentiate into multiple lineages. Multiple cutaneous carcinomas, including follicular squamous cell carcinoma (FSCC),...
Abstract Expression of the metastasis suppressor NME1 in melanoma is associated with reduced cellular motility and invasion vitro vivo, but molecular mechanisms underlying this activity are not completely understood. Herein we report a novel mechanism through which modulates focal adhesion dynamics via regulation integrin β1. Stable expression significantly altered turnover at cell periphery. Interestingly, over-expression resulted switch from predominantly fast recycling α4β1 integrins to...
Abstract 1α, 25-dihydroxyvitamin D3 (VD3) is a secosteriod that has been explored as an anti-cancer agent, but also shown to promote cell survival. Its receptor, Vitamin D Receptor (VDR), direct target of the oncogene ΔNp63α, which overexpressed in non-melanoma skin cancers. The interconnection between VDR/VD3 signaling and led us examine whether promotes keratinocyte proliferation by regulating ΔNp63α levels. We show VDR regulates expression at both transcript protein level. Interestingly,...