Niclas Håkansson
A5104110128- Nutritional Studies and Diet
- Genetic Associations and Epidemiology
- BRCA gene mutations in cancer
- Cancer Risks and Factors
- Obesity, Physical Activity, Diet
- Nutrition, Genetics, and Disease
- Colorectal Cancer Screening and Detection
- Prostate Cancer Treatment and Research
- Asthma and respiratory diseases
- Ovarian cancer diagnosis and treatment
- Consumer Attitudes and Food Labeling
- Connexins and lens biology
- Estrogen and related hormone effects
- Cancer, Lipids, and Metabolism
- Nutrition and Health in Aging
- Prostate Cancer Diagnosis and Treatment
- Bioinformatics and Genomic Networks
- Folate and B Vitamins Research
- Air Quality and Health Impacts
- Fatty Acid Research and Health
- Helicobacter pylori-related gastroenterology studies
- Inflammatory Bowel Disease
- Electromagnetic Fields and Biological Effects
- Pancreatic and Hepatic Oncology Research
- Birth, Development, and Health
Karolinska Institutet
2015-2024
University of California, Irvine
2013-2021
University of Washington
2021
University of Cambridge
2021
Cancer Council Victoria
2021
Queen's University Belfast
2021
German Cancer Research Center
2021
Fred Hutch Cancer Center
2021
Stockholm South General Hospital
2021
Agostino Gemelli University Polyclinic
2020
A high body-mass index (BMI, the weight in kilograms divided by square of height meters) is associated with increased mortality from cardiovascular disease and certain cancers, but precise relationship between BMI all-cause remains uncertain.
Stratification of women according to their risk breast cancer based on polygenic scores (PRSs) could improve screening and prevention strategies. Our aim was develop PRSs, optimized for prediction estrogen receptor (ER)-specific disease, from the largest available genome-wide association dataset empirically validate PRSs in prospective studies. The development comprised 94,075 case subjects 75,017 control European ancestry 69 studies, divided into training validation sets. Samples were...
In a pooled analysis of 20 prospective studies, Cari Kitahara and colleagues find that class III obesity (BMI 40–59) is associated with excess rates total mortality, particularly due to heart disease, cancer, diabetes. Please see later in the article for Editors' Summary
To determine whether recommended amounts of leisure-time physical activity (ie, 7.5-15 metabolic equivalent task [MET] hours/week) are associated with lower cancer risk, describe the shape dose-response relationship, and explore associations moderate- vigorous-intensity activity.Data from 9 prospective cohorts self-reported follow-up for incidence were pooled. Multivariable Cox regression was used to estimate adjusted hazard ratios (HRs) 95% CIs relationships between 15 types cancer....
To examine the relationship between Mediterranean diet and risk of later-onset Crohn's disease (CD) or ulcerative colitis (UC).We conducted a prospective cohort study 83 147 participants (age range: 45-79 years) enrolled in Cohort Swedish Men Mammography Cohort. A validated food frequency questionnaire was used to calculate an adherence score modified (mMED) at baseline 1997. Incident diagnoses CD UC were ascertained from Patient Register. We Cox proportional hazards modelling HRs 95%...
BackgroundThe association between type 1 diabetes mellitus (T1DM) and specific cardiovascular diseases (CVD) is uncertain. Furthermore, data on 2 (T2DM) in relation to risk of aortic valve stenosis, atrial fibrillation, abdominal aneurysm, intracerebral hemorrhage are scarce inconclusive. We examined the associations T1DM T2DM with incidence seven CVD outcomes.MethodsThis study comprised 71,483 Swedish adults from two population-based prospective cohorts. diagnosis incident cases were...
Tobacco smoking is a known cause of gastric cancer, but several aspects the association remain imprecisely quantified. We examined relation between cigarette and risk cancer using uniquely large dataset 23 epidemiological studies within 'Stomach Pooling (StoP) Project', including 10 290 cases 26 145 controls. estimated summary odds ratios (ORs) corresponding 95% confidence intervals (CIs) by pooling study-specific ORs random-effects models. Compared with never smokers, were 1.20 (95% CI:...
Greater height and body mass index (BMI) have been associated with an increased risk of thyroid cancer, particularly papillary carcinoma, the most common least aggressive subtype. Few studies evaluated these associations in relation to other, more histologic types or cancer-specific mortality.
We examined the associations of body mass index (BMI), waist circumference, a history diabetes, and cigarette smoking with risk pancreatic cancer among 37 147 women 45 906 men followed up during 560 666 person-years in Swedish Mammography Cohort Men; 136 incident cases were diagnosed. The multivariate rate ratio (RR) for obese (BMI ⩾30 kg/m2) was 1.81 (95% CI: 1.04–3.15) compared to those BMI 20–25 kg/m2. For difference 20 cm (about two standard deviations) RRs 1.32 0.73–2.37) 1.74...
Abstract Self-collection of saliva has the potential to provide molecular epidemiologic studies with DNA in a user-friendly way. We evaluated new Oragene collection method and requested samples by mail from 611 men (ages 53-87 years). obtained response rate of, on average, 80% [varying 89% 67-71 years) 71% 77-87 years)]. was extracted 90 randomly selected samples, its usefulness respect quality, quantity, whole-genome amplification (WGA). Visual inspection agarose gels showed high weight...
OBJECTIVES: Lifestyle factors other than dietary fiber intake and risk for colonic diverticular disease have only been examined in few studies. The objective of this study was to investigate the association between obesity physical inactivity a population-based cohort women. METHODS: This prospective study. In all, 36,592 women, born 1914–1948, Swedish Mammography Cohort were followed 1997–2009. Body mass index (BMI; kg/m2), activity, diet, smoking, lifestyle collected at baseline through...
Abstract Background The relationship between smoking and the risk of diverticular disease is unclear. An observational cohort study was undertaken to investigate association disease. Methods Women in Swedish Mammography Cohort born 1914 1948 were followed from 1997 2008. Information on other lifestyle factors collected through questionnaires. Patients with symptomatic identified national registers. Relative risks (RRs) (resulting hospital admission or death) according status estimated using...
ABSTRACT Background : A neuroprotective effect of dietary antioxidants on Parkinson's disease (PD) risk has been suggested, but epidemiological evidence is limited. Objectives To examine the associations between intake antioxidant vitamins and total capacity PD. Methods We prospectively assessed relationships C E, ß‐carotene, with PD in two population‐based cohorts (38,937 women 45,837 men). Results During a mean 14.9‐year follow‐up period, 1,329 cases were identified. Dietary ß‐carotene was...
An association between heavy alcohol drinking and gastric cancer risk has been recently reported, but the issue is still open to discussion quantification. We investigated role of on in “Stomach Pooling (StoP) Project,” a consortium epidemiological studies. A total 9,669 cases 25,336 controls from 20 studies Europe, Asia North America were included. estimated summary odds‐ratios (ORs) corresponding 95% confidence intervals (CIs) by pooling study‐specific ORs using random‐effects...
Abstract Background In addition to the established association between general obesity and breast cancer risk, central circulating fasting insulin glucose have been linked development of this common malignancy. Findings from previous studies, however, inconsistent, nature associations is unclear. Methods We conducted Mendelian randomization analyses evaluate using genetic instruments, with insulin, glucose, 2-h body mass index (BMI) BMI-adjusted waist-hip-ratio (WHRadj BMI). first confirmed...
The aim of this study was to examine the association overall and abdominal obesity with aortic valve stenosis (AVS) incidence in two prospective cohorts.We used data from Cohort Swedish Men Mammography Cohort, involving 71 817 men women who were free cardiovascular disease had reported their anthropometric measures 1997. Aortic cases ascertained through linkage nationwide registers on hospitalization causes death. Data analysed using Cox proportional hazards regression. During a mean...