Alexander Hein
A5086392926- Ovarian cancer diagnosis and treatment
- Cancer-related molecular mechanisms research
- Breast Cancer Treatment Studies
- BRCA gene mutations in cancer
- PARP inhibition in cancer therapy
- Endometrial and Cervical Cancer Treatments
- Cancer Genomics and Diagnostics
- Estrogen and related hormone effects
- Advanced Breast Cancer Therapies
- Genetic Associations and Epidemiology
- RNA modifications and cancer
- HER2/EGFR in Cancer Research
- Endometriosis Research and Treatment
- Cancer Treatment and Pharmacology
- Cancer Risks and Factors
- Reproductive System and Pregnancy
- Virus-based gene therapy research
- Cancer Immunotherapy and Biomarkers
- RNA Research and Splicing
- Neutropenia and Cancer Infections
- CRISPR and Genetic Engineering
- Genetic factors in colorectal cancer
- COVID-19 Impact on Reproduction
- Immunotherapy and Immune Responses
- Fungal Infections and Studies
Comprehensive Cancer Center Erlangen
2016-2025
Friedrich-Alexander-Universität Erlangen-Nürnberg
2016-2025
Universitätsklinikum Erlangen
2016-2025
Klinikum Esslingen
2024-2025
Novartis (Switzerland)
2023
Jazz Pharmaceuticals (United States)
2023
Karyopharm Therapeutics (United States)
2023
Bristol-Myers Squibb (Germany)
2023
AstraZeneca (Canada)
2023
Deciphera Pharmaceuticals (United States)
2023
Background Defective cellular transport processes can lead to aberrant accumulation of trace elements, iron, small molecules and hormones in the cell, which turn may promote formation reactive oxygen species, promoting DNA damage expression key regulatory cancer genes. As uncontrolled proliferation are hallmarks cancer, including epithelial ovarian (EOC), we hypothesized that inherited variation genes contributes EOC risk. Methods In total, samples were obtained from 14,525 case subjects...
Cytotoxic CD8+ tumor-infiltrating lymphocytes (TILs) participate in immune control of epithelial ovarian cancer; however, little is known about prognostic patterns TILs by histotype and relation to other clinical factors.
The pathological complete response (pCR) after neoadjuvant chemotherapy is a surrogate marker for favorable prognosis in breast cancer patients. Factors capable of predicting pCR, such as the proliferation Ki67, may therefore help improve our understanding drug and its effect on prognosis. This study investigated predictive prognostic value Ki67 patients with invasive receiving treatment cancer. was stained routinely from core biopsies 552 directly fixation embedding process. HER2/neu,...
Endometrial cancer is the most commonly diagnosed of female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, present an expanded meta-analysis 12,906 cases and 108,979 controls (including new genotype data 5624 cases) identify nine novel significant loci, including a locus on 12q24.12 by meta-GWAS colorectal At five expression quantitative trait (eQTL) analyses candidate...
Introduction MicroRNAs (miRNAs, miRs) are a class of small, non-coding RNA molecules with relevance as regulators gene expression thereby affecting crucial processes in cancer development. MiRNAs offer great potential biomarkers for detection due to their remarkable stability blood and characteristic many different diseases. We investigated whether microarray-based miRNA profiling on whole could discriminate between early stage breast patients healthy controls. Methods performed 48 at...
Detection and adaptation to cold temperature is crucial survival. Cold sensing in the innocuous range of (>10-15 °C) mammalian peripheral nervous system thought rely primarily on transient receptor potential (TRP) ion channels, most notably menthol receptor, TRPM8. Here we report that TRP cation channel, subfamily C member 5 (TRPC5), but not TRPC1/TRPC5 heteromeric are highly sensitive 37-25 °C. We found TRPC5 present mouse human sensory neurons dorsal root ganglia, a substantial number...
BackgroundATP-binding cassette (ABC) transporters play various roles in cancer biology and drug resistance, but their association with outcomes serous epithelial ovarian (EOC) is unknown.
Breast cancers demonstrate substantial biological, clinical and etiological heterogeneity. We investigated breast cancer risk associations of eight susceptibility loci identified in GWAS two putative candidate genes relation to specific tumor subtypes. Subtypes were defined by five markers (ER, PR, HER2, CK5/6, EGFR) other pathological features. Analyses included up 30 040 invasive cases 53 692 controls from 31 studies within the Cancer Association Consortium. confirmed previous reports...
Triple-negative (TN) breast cancer is an aggressive subtype of associated with a unique set epidemiologic and genetic risk factors. We conducted two-stage genome-wide association study TN (stage 1: 1529 cases, 3399 controls; stage 2: 2148 1309 controls) to identify loci that influence risk. Variants in the 19p13.1 PTHLH showed significant associations (P < 5 × 10−8) 1 2 combined. Results also suggested substantial enrichment significantly variants among single nucleotide polymorphisms (SNPs)...
Background:In vitro and observational epidemiological studies suggest that vitamin D may play a role in cancer prevention. However, the relationship between ovarian is uncertain, with generating conflicting findings. A potential limitation of inadequate control confounding. To overcome this problem, we used Mendelian randomization (MR) to evaluate association single nucleotide polymorphisms (SNPs) associated circulating 25-hydroxyvitamin [25(OH)D] concentration risk cancer. Methods: We...
Abstract Background In addition to the established association between general obesity and breast cancer risk, central circulating fasting insulin glucose have been linked development of this common malignancy. Findings from previous studies, however, inconsistent, nature associations is unclear. Methods We conducted Mendelian randomization analyses evaluate using genetic instruments, with insulin, glucose, 2-h body mass index (BMI) BMI-adjusted waist-hip-ratio (WHRadj BMI). first confirmed...
The odontoblast, with processes beyond the dentin-enamel boundary, is initial site of TRPC5 cold transduction in teeth.
Pembrolizumab is approved for the neoadjuvant/adjuvant treatment of early triple-negative breast cancer (TNBC) patients in combination with chemotherapy. The Keynote-522 trial used platinum As neoadjuvant nab-paclitaxel (nP) also highly effective patients, this study investigates response to nP-containing chemotherapy pembrolizumab.NeoImmunoboost (AGO-B-041/NCT03289819) a multicenter, prospective single-arm phase II trial. Patients were treated 12 weekly cycles nP followed by four...
Folate receptor 1 (FOLR1) is expressed in the majority of ovarian carcinomas (OvCa), making it an attractive target for therapy. However, clinical trials testing anti-FOLR1 therapies OvCa show mixed results and require better understanding prognostic relevance FOLR1 expression. We conducted a large study evaluating expression with survival different histological types OvCa. Tissue microarrays composed tumour samples from 2801 patients Ovarian Tumour Analysis (OTTA) consortium were assessed...