A5071439913- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Congenital heart defects research
- Cervical Cancer and HPV Research
- Congenital Heart Disease Studies
- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Lung Cancer Treatments and Mutations
- Gestational Trophoblastic Disease Studies
- Intraperitoneal and Appendiceal Malignancies
- Cancer Risks and Factors
- Cardiac Valve Diseases and Treatments
- Colorectal and Anal Carcinomas
- RNA modifications and cancer
- Cancer Treatment and Pharmacology
- Cardiovascular Function and Risk Factors
- Renal cell carcinoma treatment
- Estrogen and related hormone effects
- Genetic factors in colorectal cancer
- Tissue Engineering and Regenerative Medicine
- Cancer-related molecular mechanisms research
- Lung Cancer Research Studies
- Reproductive System and Pregnancy
- Reproductive Biology and Fertility
- Systemic Sclerosis and Related Diseases
Tohoku Medical and Pharmaceutical University
2018-2025
Aichi Cancer Center
2012-2023
Tohoku Medical and Pharmaceutical University Hospital
2023
Osaka University
2019-2022
Yokohama City Seibu Hospital
2020-2022
St. Marianna University School of Medicine
2021
Komatsu (Japan)
2020
Doai Memorial Hospital
2019
Tohoku Medical and Pharmaceutical University Wakabayashi Hospital
2019
Mitsui Memorial Hospital
2018-2019
Skin fibrotic disorders are understood to develop under the influence of some growth factors, such as transforming factor-beta (TGF-β), basic fibroblast factor (bFGF), or connective tissue (CTGF). To establish an appropriate animal model skin fibrosis by exogenous application we investigated in vivo effects factors injecting TGF-β, CTGF, and bFGF into subcutaneous newborn mice. A single TGF-β resulted formation transient granulated that disappeared despite 7 days consecutive injections. CTGF...
To assess the efficacy of fertility-sparing treatment using medroxyprogesterone acetate (MPA) for endometrial carcinoma (EC) and atypical hyperplasia (AH) in young women.This multicenter prospective study was carried out at 16 institutions Japan. Twenty-eight patients having EC presumed stage IA 17 with AH younger than 40 years age were enrolled. All given a daily oral dose 600 mg MPA low-dose aspirin. This continued 26 weeks, as long responded. Histologic change tissue assessed 8 weeks...
Purpose In metastatic or recurrent cervical cancer, cisplatin-based chemotherapy is standard. The JCOG0505 randomized phase III trial evaluated the clinical benefits of carboplatin-based regimen. Patients and Methods Eligible patients had cancer ≤ one platinum-containing treatment no prior taxane. were randomly assigned either to conventional paclitaxel plus cisplatin (TP; 135 mg/m 2 over 24 hours on day 1 50 2, repeated every 3 weeks) carboplatin (TC; 175 area under curve 5 mg/mL/min 1,...
BackgroundATP-binding cassette (ABC) transporters play various roles in cancer biology and drug resistance, but their association with outcomes serous epithelial ovarian (EOC) is unknown.
Purpose The objective of this study was to assess clinical outcomes and fertility in patients treated conservatively for unilateral stage I invasive epithelial ovarian cancer (EOC). Patients Methods A multi-institutional retrospective investigation undertaken identify with EOC fertility-sparing surgery. Favorable histology defined as grade 1 or 2 adenocarcinoma, excluding clear cell histology. Results total 211 (stage IA, n = 126; IC, 85) were identified from 30 institutions. Median duration...
Connective tissue growth factor (CTGF) is a and chemotactic for fibroblasts encoded by an immediate early gene that transcriptionally activated transforming factor-β. Previous studies have shown both CTGF messenger ribonuclear acid (mRNA) protein are expressed in renal fibrosis bleomycin-induced pulmonary mice. The aim of the present study was to investigate localization its mRNA expression fibrotic lung patients with idiopathic (IPF). Using human obtained from eight autopsy cases four...
HNF1B is overexpressed in clear cell epithelial ovarian cancer, and we observed epigenetic silencing serous leading us to hypothesize that variation this gene differentially associates with cancer risk according histological subtype. Here comprehensively map respect analyse DNA methylation expression profiles across subtypes. Different single-nucleotide polymorphisms associate invasive (rs7405776 odds ratio (OR)=1.13, P=3.1 × 10−10) (rs11651755 OR=0.77, P=1.6 10−8) cancer. Risk alleles for...
Recent advances in bronchoscopy, such as transbronchial biopsy (TBB) using endobronchial ultrasonography with a guide sheath (EBUS-GS), have improved the diagnostic yield of small-sized peripheral lung lesions. In some cases, however, it is difficult to obtain adequate samples for pathological diagnosis. Adequate prediction accuracy TBB EBUS-GS important before deciding whether bronchoscopy should be performed.We retrospectively reviewed 149 consecutive patients who underwent lesions (≤30 mm...
To examine the association between surgical volume and survival of women with early-stage cervical cancer who underwent radical hysterectomy.This is a nationwide multicenter retrospective study examining consecutive clinical stage IB1-IIB hysterectomy pelvic lymphadenectomy from 2004 to 2008 (N=5,964). The per site over 5-year period was defined as low-volume (fewer than 32 surgeries, 46 [39.7%] institutions, n=649 [10.9%]), mid-volume (32-104 60 [51.7%] n=3,662 [61.4%]), high-volume (105...
The efficacy of taxane plus platinum regimens has been demonstrated for advanced or recurrent endometrial cancer; however, it not assessed in postoperative adjuvant chemotherapy cancer.To evaluate the clinical benefit compared with standard doxorubicin cisplatin as cancer.In this multicenter, open-label, phase 3 randomized trial, patients cancer at high-risk stage I II III IV that did extend beyond abdominal cavity and had 2 cm greater residual tumor were included from 118 institutions Japan...
Fulminant myocarditis presentation (FMP) is a rare and severe of myocarditis. The natural history FMP its clinical features associated with poor outcomes are incompletely understood because there lack generalizable evidence.This multicenter retrospective cohort study included patients hospitalized histologically proven who underwent catecholamine or mechanical support from 235 cardiovascular training hospitals across Japan between April 2012 March 2017. Clinical the prognostic predictors...
Prolonged incubation with interleukin-1 beta (IL-1) induced the release of large amounts NO and subsequently inhibited DNA synthesis biosynthesis accumulation proteoglycans in cultured rabbit articular chondrocytes (RAC). IL-1 also bovine aortic endothelial cells (BAE). On other hand, BAE cocultured RAC was not by prolonged IL-1. Moreover, conditioned media from incubated for a long period stimulated alone. This growth stimulatory activity mainly due to basic fibroblast factor,...
This study aimed to assess the prognostic significance of para-aortic lymphadenectomy (PALX) and lymph node metastasis in endometrial cancer (EC) patients at risk post-operative recurrence. Japanese Gynecologic Oncology Group (JGOG) 2043 was a randomized controlled trial assessing efficacy adjuvant chemotherapy EC for A retrospective analysis included who underwent pelvic (PLX) alone or both PLX PALX JGOG2043. Data on positive nodes other clinicopathological factors were collected. performed...