A5086011356- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Cervical Cancer and HPV Research
- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Intraperitoneal and Appendiceal Malignancies
- Renal cell carcinoma treatment
- Cancer Risks and Factors
- Lymphoma Diagnosis and Treatment
- Reproductive Biology and Fertility
- Genetic factors in colorectal cancer
- Multiple and Secondary Primary Cancers
- Cancer Cells and Metastasis
- PARP inhibition in cancer therapy
- Neuroendocrine Tumor Research Advances
- Childhood Cancer Survivors' Quality of Life
- Photodynamic Therapy Research Studies
- Cancer-related molecular mechanisms research
- Sarcoma Diagnosis and Treatment
- Lung Cancer Research Studies
- Gynecological conditions and treatments
- Palliative Care and End-of-Life Issues
- Colorectal and Anal Carcinomas
- Gestational Trophoblastic Disease Studies
- Chromatin Remodeling and Cancer
Kagoshima University
2020-2025
Kagoshima University Hospital
2021-2024
Aichi Cancer Center
2006-2022
Kagoshima City Hospital
2022
Nagoya University
2003-2020
Japanese Red Cross Nagoya Daiichi Hospital
2004-2006
Data are limited regarding the use of poly(adenosine diphosphate [ADP]-ribose) polymerase inhibitors, such as veliparib, in combination with chemotherapy followed by maintenance initial treatment patients high-grade serous ovarian carcinoma. In an international, phase 3, placebo-controlled trial, we assessed efficacy veliparib added to first-line induction carboplatin and paclitaxel continued monotherapy previously untreated stage III or IV Patients were randomly assigned a 1:1:1 ratio...
This phase III, multicenter, randomized, open-label study investigated the efficacy and safety of nivolumab versus chemotherapy (gemcitabine [GEM] or pegylated liposomal doxorubicin [PLD]) in patients with platinum-resistant ovarian cancer.
This study aimed to report the first surgery for gynecological diseases using a new robotic platform, hinotori™, and validate its feasibility in clinical settings.The world's robot-assisted total hysterectomy ailment was carried out at Kagoshima University Hospital December 2022 utilizing hinotori™ surgical robot system. Eleven other patients then underwent comparable procedures. The team certified execute procedure had undergone official training.Preoperative diagnoses indicated five cases...
The efficacy of taxane plus platinum regimens has been demonstrated for advanced or recurrent endometrial cancer; however, it not assessed in postoperative adjuvant chemotherapy cancer.To evaluate the clinical benefit compared with standard doxorubicin cisplatin as cancer.In this multicenter, open-label, phase 3 randomized trial, patients cancer at high-risk stage I II III IV that did extend beyond abdominal cavity and had 2 cm greater residual tumor were included from 118 institutions Japan...
There were a few reports of large number patients with clear cell adenocarcinoma (CCA) the ovary because low incidence CCA. This study compared clinical factors affecting long-term survival CCA to those serous cystadenocarcinoma (SCA).One hundred and seventy-eight 311 SCA treated between 1987 2000 retrospectively evaluated. Differences in rates calculated using log-rank test Cox's proportional hazards analysis was used identify independent prognostic factors.The ratio stage I significantly...
To compare the clinical outcome of patients with stage I epithelial ovarian cancer (EOC) who received fertility-sparing surgery (FSS) those underwent radical (RS). After a central pathological review and search medical records from multiple institutions, total 572 were retrospectively evaluated. All divided into three groups: group A {FSS (n=74); age, ⩽40}; groups B C [RS; 40⩾{(B), n=52}; 40<{(C), n=446}]. Five-year overall survival (OS) disease-free (DFS) rates in as follows: A, 90.8%...
ObjectiveTo evaluate the diagnostic utility of one-step nucleic acid amplification (OSNA) assay for intraoperative assessment whole sentinel lymph nodes (SNs) in endometrial cancer.MethodsA prospective analysis was conducted on 204 patients with low-risk cancer who underwent hysterectomy, bilateral salpingo-oophorectomy, and node navigation surgery. SNs were analyzed intraoperatively using OSNA assay, positive systematic pelvic lymphadenectomy.ResultsAmong included patients, SN metastases...
Introduction Simple hysterectomy (SH) is a frequently performed surgery for treating benign uterine conditions. The da Vinci® Surgical System (dVSS; Intuitive Surgical, Inc., Sunnyvale, California, US) received FDA approval in 2005 robot-assisted minimally invasive gynecological surgeries. In Japan, insurance coverage dVSS applications conditions, such as myomas, began 2018, driving sharp rise robotic procedures. hinotori™ Robot (hinotori; Medicaroid Corporation, Kobe, Japan), developed was...
Abstract Objective This study evaluates clinicopathological outcomes and clinicians' awareness regarding the management of atypical glandular cells (AGC). Methods We analyzed 98 AGC cases, excluding known endometrial cancer, from 238 initial with a median age 42 years (range 20–82). Cytological findings, including NOS FN subcategories, diagnostic tests, treatments, were evaluated. A survey on practices was conducted among 134 obstetrician‐gynecologists. Results Of cases (AGC‐FN: 19.8%,...
<title>Abstract</title> Background The incidence of endometrial cancer in Japan has more than doubled over the past 2 decades because increasing obesity rates and unique physiological traits Asian populations. aim this retrospective study was to examine impact on surgical outcomes, prognosis, costs. Methods A total 197 patients with stage IA who underwent robot-assisted hysterectomy, bilateral salpingo-oophorectomy, lymphadenectomy/biopsy from 2018 onward were included. Patients divided into...
Abstract Aim Medroxyprogesterone acetate ( MPA ) is used to preserve fertility in patients with G rade 1 endometrial cancer without myometrial invasion G1EA and those atypical hyperplasia AEH ). However, the efficacy of retreatment has not been sufficiently established for who experience recurrence but wish retain their fertility. This study aimed show effectiveness treatment . Methods A total 39 received between 2005 2015, including nine 30 The high‐dose (600 mg/day) 26 weeks. If a complete...
<i>Objective:</i> There are a few long-term follow-up studies of patients with stage I ovarian carcinoma. The objective this study was to evaluate prognostic factors for survival. <i>Methods:</i> Two hundred fourteen carcinomas (registered by the Tokai Ovarian Tumor Study Group from 1988 1999) were analyzed. Staging according International Federation Gynecology and Obstetrics set without considering pathologic findings lymph nodes. Stage Ic divided into Ic(b) other...
<h3>Objectives</h3> To estimate the long-term clinical outcome of patients with recurrent clear cell carcinoma (RCCC) ovary in comparison those serous adenocarcinoma (RSAC). <h3>Patients and Methods</h3> In this study, 113 RCCC 365 RSAC were analyzed. The pathological slides evaluated under central review. End points overall survival (OS), postrecurrence (PRS), timing death mortality cases. <h3>Results</h3> 5-year OS PRS rates 22.5 13.2%, respectively. both PRS, prognosis was significantly...
We aimed to evaluate the radioprotective effect of hydrolyzed rice bran (HRB) on acute gastroenteritis due chemoradiotherapy for treatment cervical cancer. This placebo-controlled, double-blind study was conducted as an exploratory investigation colitis-inhibiting effects HRB in alleviating acute-phase gastrointestinal side chemoradiotherapy. The involved 20 patients (10 group, 10 control group). group underwent same regimen those but they received a placebo instead HRB. diarrheal assessment...
It is controversial whether patients with stage I ovarian clear cell carcinoma (CCC) benefit from postoperative chemotherapy. This study was designed to evaluate the outcomes associated inclusion or exclusion of adjuvant therapy in these patients.A total 185 who were treated for CCC between 1991 and 2007 retrospectively evaluated. All had received comprehensive surgical staging, their condition been diagnosed by a central pathological review system. Only one patient IB excluded this...
Primary ovarian malignant germ cell tumors (OMGCTs) are rare and difficult to diagnose. Immunohistochemistry can help in the diagnosis development of new management strategies. The aim this study was investigate frequency CD117, CD133, SALL4, OCT4, TCL1 glypican-3 marker expression OMGCTs.We examined six markers 87 (85 pure two mixed OMGCTs) cases OMGCT using immunohistochemical staining. Staining graded a semiquantitative manner as follows: negative (no staining), 1+ (1-30% 2+ (31-60% or 3+...