A5068679494- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Pregnancy and preeclampsia studies
- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Birth, Development, and Health
- Cancer Risks and Factors
- Reproductive System and Pregnancy
- COVID-19 Impact on Reproduction
- Cervical Cancer and HPV Research
- Neonatal Respiratory Health Research
- Cytomegalovirus and herpesvirus research
- Intraperitoneal and Appendiceal Malignancies
- Reproductive Biology and Fertility
- PARP inhibition in cancer therapy
- Gynecological conditions and treatments
- Renal cell carcinoma treatment
- Maternal and fetal healthcare
- Assisted Reproductive Technology and Twin Pregnancy
- Colorectal and Anal Carcinomas
- Maternal and Perinatal Health Interventions
- Pregnancy and Medication Impact
- Gastric Cancer Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Neonatal and fetal brain pathology
Mie University
2013-2025
Tohoku University
2025
Hokkaido University Hospital
2024
Mie University Hospital
2015-2024
Ōtani University
2024
Weatherford College
2023
Miyagi University of Education
2023
Shinshu University
2022
Kyoto University
2013-2022
Tokai University
2021
This phase III, multicenter, randomized, open-label study investigated the efficacy and safety of nivolumab versus chemotherapy (gemcitabine [GEM] or pegylated liposomal doxorubicin [PLD]) in patients with platinum-resistant ovarian cancer.
BACKGROUND: Intraperitoneal chemotherapy has been shown to be effective at reducing mortality for patients with advanced epithelial ovarian cancer but is not widely used in practice. METHODS: We performed the Therapy Ovarian Cancer Carboplatin (iPocc) trial as an open-label, international, multi-institutional, randomized phase 2/3 clinical women newly diagnosed who underwent laparotomy or laparoscopy. All received intravenous paclitaxel (80 mg/m2 on days 1, 8, and 15 of a 21-day cycle). In...
Chronic kidney disease (CKD) causes progressive and irreversible damage to the kidneys. Renal biopsies are essential for diagnosing etiology prognosis of CKD, while accurate quantification tubulo-interstitial injuries from whole slide images (WSIs) renal biopsy specimens is challenging with visual inspection alone. We develop a deep learning-based method named DLRS quantify interstitial fibrosis inflammatory cell infiltration as injury scores, WSIs specimens. segments into non-tissue areas,...
Ovarian cancer has a poor prognosis, and screening methods have not been established. Biomarkers based on molecular genetic characteristics must be identified to develop diagnostic therapeutic strategies for all types, particularly ovarian cancer. The present study aimed evaluate the usefulness of analysis cervical endometrial liquid-based cytology (LBC) specimens detecting somatic mutations in patients with data 19 treated between August 2019 July 2022 were analyzed. LBC from cervix...
There are already 12 reports of women treated by chemotherapy for epithelial ovarian cancer during pregnancy. However, most cases received single cisplatin or cisplatin-based regime, and only four carboplatin-containing chemotherapy. We report the case a woman with single-agent carboplatin The patient underwent bilateral salpingo-oophorectomy at 18 weeks gestation was diagnosed as having stage IC undifferentiated carcinoma. She courses (area under curve = 6.0) pregnancy without severe...
Abstract BACKGROUND We investigated the efficacy and mechanisms of tadalafil, a selective phosphodiesterase 5 inhibitor, in treating preeclampsia (PE) with fetal growth restriction (FGR) using L-NG-nitroarginine methyl ester (L-NAME)-induced PE FGR pregnant mice as our experimental model. METHODS C57BL/6 were divided into 2 groups 11 days postcoitum (d.p.c.). A control group dams (C dam) received 0.5% carboxymethylcellulose (CMC). L-NAME-treated 1 mg/ml L-NAME dissolved CMC. The subgroups 13...
Interim results from the two-cohort, phase 2 KEYNOTE-100 study (NCT02674061) of 376 patients with previously treated advanced recurrent ovarian cancer (ROC) showed that pembrolizumab monotherapy was associated an objective response rate (ORR) 8.0% (95% CI, 5.4-11.2). We present outcomes for Japanese (n = 21) enrolled in KEYNOTE-100. Patients epithelial ROC had received either 1-3 prior chemotherapy lines and platinum-free interval or treatment-free (PFI; TFI) 3-12 months (cohort A) 4-6...
Abstract Aim We designed a safety and dose‐finding trial of tadalafil administered for fetal growth restriction (FGR). Methods Three cases were initially commenced on 10 mg/day monitored major adverse events. Should event be observed in one or more the three cases, an examination into its relation with would conducted by evaluation committee. If these new exhibited same event, stopped completely. there no harmful side‐effects, extended to at 20 mg/day, protocol continue as 10‐mg/day dose....
Tadalafil is a phosphodiesterase 5 (PDE5) inhibitor with long half-life, high selectivity, and rapid onset of action. Because the safety using PDE5 inhibitors as therapeutic agents for fetal growth restriction (FGR) has been problem worldwide, this paper primarily focuses on assessments performed in Treatment Fetuses Early-Onset Growth Restriction (TADAFER) II population. Neonatal maternal adverse events were analyzed, addition to fetal, neonatal, infant death cases, six months after...
Abstract We have demonstrated that tadalafil facilitates fetal growth in mice with L-NG-nitroarginine methyl ester (L-NAME)-induced preeclampsia (PE) restriction (FGR). Tadalafil is a selective phosphodiesterase 5 inhibitor dilates the maternal blood sinuses placenta, thereby facilitating of fetus. The purpose this study was to investigate effects treatment for PE and FGR on developing brain offspring using an L-NAME-induced mouse model FGR. A control group dams received...
Although various perinatal outcomes in coronavirus disease 2019 (COVID-19) pregnancies have been reported, the fetal and neonatal consequences of severe acute respiratory syndrome 2 (SARS-CoV-2) infection remain unclear. Several reports miscarriages stillbirths recorded, but vertical transmission by SARS-CoV-2 is considered very rare, cause remains unknown. We report a case 22-year-old uncomplicated Japanese woman infected with during second trimester, resulting intrauterine death due to...
<h3>Background</h3> The standard treatment for stage IB–IIB cervical cancer is radiotherapy or radical hysterectomy; after hysterectomy, adjuvant concurrent chemoradiotherapy recommended patients with high risk factors. However, can cause severe gastrointestinal and urinary toxicity. <h3>Primary Objective</h3> To assess whether postoperative chemotherapy not inferior to overall survival in cancer. <h3>Study Hypothesis</h3> Adjuvant will reduce toxicities. <h3>Trial Design</h3> Patients...
In vitro maturation (IVM) of human oocytes offers an invaluable opportunity for infertility treatment. However, in matured often show lower developmental abilities than their vivo counterparts, and molecular mechanisms underlying successful remain unclear. this study, we investigated gene expression profiles at the single-cell level to gain mechanistic insight into IVM oocytes.Human were retrieved by follicular puncture matured. total, 19 from 11 patients collected subjected RNA-seq...
The prognosis and vaginal disease control rate after treatment with radiotherapy or concurrent chemoradiotherapy (CCRT) are reported to be worse for primary non-squamous cell carcinoma (non-SCC) of the vagina than squamous (SCC) vagina. Our objective was examine clinicopathological characteristics non-SCC suggest an appropriate strategy.In a retrospective chart review, we identified patients cancer who were treated in our hospital between 1990 2013. Twelve histologically diagnosed...
In most patients, stage IVB cervical cancer is incurable, and the outcomes are poor. There significant individual variation in patients with cancer, whom standard treatment has not been well defined. This study aims to review discuss strategies cancer.From January 1, 1992, December 31, 2011, we retrospectively reviewed data of who were given a diagnosis at Department Gynecology Cancer Institute Hospital.A total 111 enrolled. At time analysis, median overall survival (OS) was 16.6 months...
Objective: Office methods of endometrial sampling for outpatients with abnormal uterine bleeding should be minimally invasive. The purpose this study was to determine the best method detecting cancer in an setting. Methods: In all, 114 symptomatic women who were suspected having disease by their local gynaecologist enrolled study. After pelvic examination and transvaginal ultrasonography, cytology, suction curettage, four‐site biopsy performed, order without anaesthesia each patient....
<h3>Objective:</h3> To evaluate the effect of a sodium hyaluronate and carboxymethylcellulose membrane (Seprafilm) on early postoperative small bowel obstruction (EPSBO) in patients with gynecologic malignancies. <h3>Methods:</h3> One hundred forty-five who had Seprafilm placed during gynecological surgery between April 2002 March 2007 (Seprafilm group) were compared historical control group managed without January 1997 2002. All undergoing primary pelvic or combined para-aortic...
Similar to primary debulking surgery, complete resection of all macroscopic diseases during interval surgery (IDS) is the objective while using neoadjuvant chemotherapy followed by IDS for advanced ovarian, fallopian tube, and peritoneal cancers. However, most patients develop recurrent disease even after cytoreduction IDS. This study aims identify recurrence patterns cancers in who underwent IDS.We retrospectively reviewed data with stage III or IV were treated at our hospital from January...
The purpose of this study was to analyze the prognosis for endometrial cancer patients treated with systematic pelvic and para-aortic lymphadenectomy (PLA PALA) followed by platinum-based chemotherapy.From 1994 2004, in Cancer Institute Hospital, 502 who were surgically PLA PALA enrolled study. Their clinicopathological features retrospectively reviewed.One hundred ninety-one (38.0%) received adjuvant chemotherapy. Lymph node (LN) metastasis observed 80 (15.9%) patients, pelvic-only LN 27...