A5088518123- Dialysis and Renal Disease Management
- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Hydrogen's biological and therapeutic effects
- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Erythropoietin and Anemia Treatment
- Autoimmune Bullous Skin Diseases
- Organ Donation and Transplantation
- Electrolyte and hormonal disorders
- Platelet Disorders and Treatments
- Renal and Vascular Pathologies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Renin-Angiotensin System Studies
- Systemic Lupus Erythematosus Research
- Chronic Disease Management Strategies
- Synthesis and properties of polymers
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Hormonal Regulation and Hypertension
- Blood Pressure and Hypertension Studies
- Vasculitis and related conditions
- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Nutrition and Health in Aging
- Renal function and acid-base balance
Tohoku University Hospital
2015-2025
Tohoku University
2015-2025
Koga Hospital
2025
Saga University
2021-2023
Fujikura (Japan)
2023
Sendai City Hospital
2023
Hitachi (Japan)
2007-2021
National Center of Neurology and Psychiatry
2017-2020
Centre for Nursing Innovation
2014
Chiba East Hospital
2010-2012
AA amyloidosis is a rare renal complication of Waldenström's macroglobulinemia/lymphoplasmacytic lymphoma (WM/LPL). A 66-year-old man with WM/LPL presented nephrotic syndrome. biopsy showed amyloidosis. Chemotherapy resulted in the remission hematologic and syndromes. Two years into follow-up, he became infected COVID-19 had massive proteinuria, despite no relapse WM/LPL. second confirmed diagnosis However, increased prednisolone did not improve proteinuria. The patient ultimately died...
Although ischemia-reperfusion of mouse kidney is known to cause severe renal failure due tubular cell death, the exact cellular mechanism responsible for this phenomenon not clear. To investigate spatial and temporal development death role Fas/APO-1/CD95 (Fas) in process, left vessels were occluded a group mice 30, 60, or 120 min followed by reperfusion 24 h (n = 4 each group). Analysis isolated DNA agarose-gel electrophoresis revealed typical ladder pattern bands consisting multiples 180...
Chronic kidney disease (CKD) causes progressive and irreversible damage to the kidneys. Renal biopsies are essential for diagnosing etiology prognosis of CKD, while accurate quantification tubulo-interstitial injuries from whole slide images (WSIs) renal biopsy specimens is challenging with visual inspection alone. We develop a deep learning-based method named DLRS quantify interstitial fibrosis inflammatory cell infiltration as injury scores, WSIs specimens. segments into non-tissue areas,...
Nicotinamide adenine dinucleotide (NAD+) supplies energy for deoxidation and anti-inflammatory reactions fostering the production of adenosine triphosphate (ATP). The kidney is an essential regulator body fluids through excretion numerous metabolites. Chronic disease (CKD) leads to accumulation uremic toxins, which induces chronic inflammation. In this study, role NAD+ in was investigated supplementation nicotinamide (Nam), a precursor NAD+, adenine-induced CKD mouse model. Nam reduced...
Abstract Background Infection control for the novel coronavirus disease 2019 (COVID-19) has been linked to decreased physical activity and nutritional deterioration in general population; however, influence on hemodialysis (HD) patients is not well discussed. Methods This multicenter retrospective study utilized Geriatric Nutritional Risk Index (GNRI), Survival Index, Japanese HD (NRI-JH) assess status body composition over five observation periods. The primary endpoint was fluid removal...
Podocytes are key components of the glomerular filtration barrier, and their injury leads to proteinuria, chronic kidney disease (CKD), nephrotic syndrome. Effective treatments for these conditions not well established, prevention podocyte is a crucial challenge. Nicotinamide (NAM), form vitamin B3, has been reported exert beneficial effects in various renal models due its antioxidant anti-inflammatory properties ability replenish nicotinamide adenine dinucleotide (NAD + ). However, impact...
Elevated serum creatinine is associated with poor outcome in IgA nephropathy (IgAN). The efficacy and limitations of corticosteroids advanced IgAN (Cr >or=1.5 mg/dl), however, remains controversial.We retrospectively investigated 70 patients mg/dl) classified into three groups according to their treatment regimens, that is, steroid pulse tonsillectomy, conventional steroid, supportive therapy. We evaluated the elucidate predictors for endpoints ESRF doubled from baseline.Steroid therapy were...
Abstract Recent studies have revealed unique biological characteristics of molecular hydrogen (H 2 ) as an anti-inflammatory agent. We developed a novel haemodialysis (E-HD) system delivering H (30–80 ppb)-enriched dialysis solution by water electrolysis, and conducted non-randomized, non-blinded, prospective observational study exploring its clinical impact. Prevalent chronic HD patients were allocated to either the E-HD (n = 161) group or conventional (C-HD: n 148) group, received...
Erythrocyte mass contributes to maintaining systemic oxygen delivery and blood viscosity, with the latter being one of determinants pressure. However, physiological response pressure changes under anaemic conditions remain unknown. We show that anaemia decreases in human patients mouse models. Analyses pathways related regulation demonstrate enhances expression gene encoding vasopressor substance renin kidneys. Although kidney juxtaglomerular cells are known continuously produce renin, renal...
Background Fatigue is one of the most frequent complications in dialyzed patients and associated with poorer patient outcomes. Multiple factors are reported to be fatigue development. Of them, impacts dialysis modalities remain unknown. Methods A total 194 (mean age, 61±11 years; 134 males; included hemodialysis (HD) 26, online hemodiafiltration (HDF) 74, peritoneal (PD) 68, combined therapy PD HD 26 cases) were recruited for this cross-sectional study. was assessed using Profile Mood States...
Uremic sarcopenia is a serious clinical problem associated with physical disability and increased morbidity mortality. Methylglyoxal (MG) highly reactive, dicarbonyl uremic toxin that accumulates in the circulatory system patients chronic kidney disease (CKD) related to pathology of sarcopenia. The pathophysiology multifactorial; however, details remain unknown. We investigated mechanisms MG-induced muscle atrophy using mouse myoblast C2C12 cells, focusing on intracellular metabolism...
The effectiveness of steroid pulse therapy combined with tonsillectomy (ST) has been shown in immunoglobulin A nephropathy (IgAN) patients moderate or severe urinary abnormalities. present study aimed to clarify whether the may be extrapolated IgAN minor abnormalities, and depend on histological severity abnormalities.Data 388 diagnosed by renal biopsies between 1987 2000 Sendai Shakaihoken Hospital, who presented glomerular haematuria minimal proteinuria (<or=0.5 g/day) at baseline, were...
Recently, nephronophthisis (NPH) has been considered a monogenic cause of end-stage renal disease (ESRD) in adults. However, adult-onset NPH is difficult to accurately diagnose and not reported cohort study. In this study, we assessed the genetic background clinicopathologic features adult NPH.We investigated 18 sporadic patients who were suspected as having by biopsy. We analyzed 69 genes that hereditary cystic kidney compared findings between with without pathogenic mutations NPH-causing...
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