A5007462658- Renal Diseases and Glomerulopathies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Glycosylation and Glycoproteins Research
- Dialysis and Renal Disease Management
- Tissue Engineering and Regenerative Medicine
- Muscle and Compartmental Disorders
- Renal Transplantation Outcomes and Treatments
- Genetic and Kidney Cyst Diseases
- Abdominal Surgery and Complications
- Diabetes Treatment and Management
- Intestinal and Peritoneal Adhesions
- Complement system in diseases
- Autoimmune Bullous Skin Diseases
- Erythrocyte Function and Pathophysiology
- Chronic Kidney Disease and Diabetes
- Xenotransplantation and immune response
- Escherichia coli research studies
- Galectins and Cancer Biology
- Meat and Animal Product Quality
- Pediatric Urology and Nephrology Studies
- Renal and related cancers
- Diabetes and associated disorders
- Parathyroid Disorders and Treatments
- Polyomavirus and related diseases
- Cell Adhesion Molecules Research
University of Tsukuba
2019-2025
Showa University
2024-2025
University of California, San Diego
2016-2023
Tokyo Women's Medical University
1992-2018
Yamagata Research Institute Of Technology
2015
Japan Kidney Foundation
2014
Kidney Centre
2010-2012
Significance Cardiovascular disease (CVD) events like heart attacks and strokes due to atherosclerotic narrowing of arteries are the commonest cause worldwide deaths, but many first-time occur in individuals without known risk factors. In contrast, such extremely rare other animals despite some same While environmental behavioral factors likely contribute difference, we show here that a human-specific genetic mutation affecting cell-surface molecules called sialic acids may be one factor. We...
Background The effects of novel biocompatible peritoneal dialysis (PD) solutions on human membrane pathology have yet to be determined. Quantitative evaluation biopsy specimens may reveal the new pathology. Methods Peritoneal from 24 PD patients being treated with either acidic solution containing high-glucose degradation products [GDPs ( n = 12)] or neutral low GDPs 12) were investigated at end PD. As controls, pre-PD specimens, obtained 13 catheter insertion, also investigated. extent...
Abstract Malignant neoplasms arise within a region of chronic inflammation caused by tissue injuries. Inflammation is key factor involved in all aspects tumorigenesis including initiation, proliferation, invasion, angiogenesis, and metastasis. Interleukin-1 (IL-1) plays critical functions tumor development with influencing the microenvironment promoting cancer progression. However, mechanism continuous activation IL-1-mediated inflammatory pathway has not been fully elucidated. This study...
Birt-Hogg-Dubé syndrome (BHDS) is an autosomal dominant disease caused by germline folliculin (FLCN) mutations and it characterized skin folliculomas, pulmonary cysts, renal cell carcinomas (RCC). We herein report the first case of a female patient with BHDS who was diagnosed multiple myeloma. Daratumumab-based treatment effective, remained responsive for over three years. Whole-exome sequencing confirmed FLCN mutation nine somatic mutations, including MPDZ mutation, which component...
<p>The NF-κB reporter activation by IL-1 in SCC cell lines.</p>
<p>Promotion of NF-κB targets’ transcription by THG-1 in oncogenic RAS-transformed HaCaT cells.</p>
<p>Phosphorylation of THG-1 by EGF and IL-1 signaling.</p>
<div>Abstract<p>Malignant neoplasms arise within a region of chronic inflammation, which is key factor in all aspects tumorigenesis including initiation, proliferation, invasion, angiogenesis, and metastasis. IL-1 plays critical functions tumor development by influencing the microenvironment promoting cancer progression. However, mechanism continuous activation IL-1–mediated inflammatory pathway tumors has not been fully elucidated. This study provides novel autocrine signaling...
<p>Secretion of IL-1β in SCC cells.</p>
<p>Wound closure assay and Matrigel invasion in TE13 cells.</p>
Postoperative intra-abdominal adhesions remain an unsolved problem despite significant progress in the surgical procedures themselves. They often lead to small-bowel obstruction, chronic abdominal and pelvic pain, as well female infertility. The loss of mesothelial cells several components inflammatory system following injury peritoneum results fibrin formation angiogenesis. remaining matrix angiogenesis replacement by fibroblasts fibrous band formation. aim this study was develop a new...
Transplantation-associated thrombotic microangiopathy (TA-TMA) is relatively rare and requires immediate intervention to avoid irreversible organ damage or death; however, consensus regarding the treatment approach lacking. Atypical haemolytic uraemic syndrome (aHUS) a disease caused by dysregulation of alternative complement pathway resulting in TMA. aHUS histologically similar TA-TMA; approximately 60% TA-TMA patients have dysregulation. Eculizumab, humanized anti-C5 monoclonal antibody,...
Recently, nephronophthisis (NPH) has been considered a monogenic cause of end-stage renal disease (ESRD) in adults. However, adult-onset NPH is difficult to accurately diagnose and not reported cohort study. In this study, we assessed the genetic background clinicopathologic features adult NPH.We investigated 18 sporadic patients who were suspected as having by biopsy. We analyzed 69 genes that hereditary cystic kidney compared findings between with without pathogenic mutations NPH-causing...
Objective: Species-specific pseudogenization of the CMAH gene during human evolution eliminated common mammalian sialic acid N -glycolylneuraminic (Neu5Gc) biosynthesis from its precursor -acetylneuraminic (Neu5Ac). With metabolic nonhuman Neu5Gc incorporation into endothelia red meat, major dietary source, anti-Neu5Gc antibodies appeared. Human-like Ldlr −/− Cmah mice on a high-fat diet supplemented with Neu5Gc-enriched mucin, to mimic meat consumption, suffered increased atherosclerosis if...