A5063612984- Hearing, Cochlea, Tinnitus, Genetics
- Vestibular and auditory disorders
- Head and Neck Cancer Studies
- Hearing Loss and Rehabilitation
- Head and Neck Surgical Oncology
- Ear and Head Tumors
- Oral and Maxillofacial Pathology
- Salivary Gland Tumors Diagnosis and Treatment
- interferon and immune responses
- Electron Spin Resonance Studies
- Ion Channels and Receptors
- Cancer Research and Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Cytokine Signaling Pathways and Interactions
- Genomics, phytochemicals, and oxidative stress
- Lipid Membrane Structure and Behavior
- NF-κB Signaling Pathways
- Tracheal and airway disorders
- Histiocytic Disorders and Treatments
- Sphingolipid Metabolism and Signaling
- Dysphagia Assessment and Management
- Tumors and Oncological Cases
- Cancer and Skin Lesions
- Meningioma and schwannoma management
- Nitric Oxide and Endothelin Effects
University of Tsukuba
2016-2025
National Hospital Organization Mito Medical Center
2023
Tsukuba Memorial Hospital
2023
Dokkyo Medical University
2023
Kōchi University
2019-2022
Hiroshima University
2015-2020
State of Illinois
2020
Hiroshima University of Economics
2019
Historical Archives
2017
VA San Diego Healthcare System
2007
In recent years, many of Japanese workers have complained fatigue and stress, considering them as risk factors for depression. Studies found that "forest bathing" (Shinrin-yoku) has positive physiological effects, such blood pressure reduction, improvement autonomic immune functions, well psychological effects alleviating depression improving mental health. this study, we investigate the on people a working age with without depressive tendencies.We conducted measurements surveys before after...
Nasopharyngeal carcinoma (NPC) is a unique disease with clinical presentation, epidemiology, and histopathology differing from other squamous cell carcinomas of the head neck. NPC an Epstein-Barr virus-associated malignancy marked racial geographic distribution. Specifically, it highly prevalent in southern China, Southeast Asia, Middle East. To date, most patients have been diagnosed advanced stage, but treatment results for are not satisfactory. This paper provides brief overview regarding...
To date, no therapeutic option has been established for sudden deafness refractory to systemic corticosteroids. This study aimed examine the efficacy and safety of topical insulin-like growth factor-1 (IGF-1) therapy in comparison intratympanic corticosteroid therapy.We randomly assigned patients with corticosteroids receive either gelatin hydrogels impregnated IGF-1 middle ear (62 patients) or four injections dexamethasone (Dex; 58 patients). The primary outcome was proportion showing...
Basal cell carcinoma (BCC) is a malignant neoplasm derived from nonkeratinizing cells that originate the basal layer of epidermis and most frequent type skin cancer in humans, with cumulative exposure to ultraviolet radiation as an important risk factor. BCC occurs frequently at sun-exposed sites, head neck being common areas. Tumors can be classified nodular, superficial, morpheaform, infiltrating, metatypic, fibroepithelioma Pinkus. Several treatment options such surgical excision...
The purpose of this study was to evaluate the prognostic potential modified Glasgow score (mGPS), known reflect degree tumor-associated inflammation and cancer cachexia, in patients with advanced head neck cancer.Patients treated at University Tsukuba Hospital between January 2002 December 2011 were retrospectively evaluated. They categorized by their mGPS.A total 210 enrolled study. Patients an mGPS 0 had better overall survival disease-free than did those 1 or 2. Multivariate analysis...
Objective The Geriatric Nutritional Risk Index (GNRI) is a simple and well‐established nutritional assessment tool significant prognostic factor in various cancers. However, the role of GNRI predicting clinical outcomes patients with advanced head neck cancer (AHNC) has not been investigated. aim present study was to examine association between prognosis AHNC. Study Design Retrospective cohort study. Methods Data collected 2002 2013 from Tsukuba University Hospital were reviewed. calculated...
A significantly increased risk for dominant sensorineural deafness in patients who have Hirschsprung disease (HSCR) caused by endothelin receptor type B and SOX10 has been reported. Despite the fact that c- RET is most frequent causal gene of HSCR, it not determined whether impairments Ret cause congenital mice humans. Here, we show impaired phosphorylation c-Ret at tyrosine 1062 causes HSCR-linked syndromic knockin (KI) mice. The involves neurodegeneration spiral ganglion neurons (SGNs)...
A large amount of energy produced by active aerobic metabolism is necessary for the cochlea to maintain its function. This makes vulnerable blockade cochlear blood flow and interruption oxygen supply. Although certain forms human idiopathic sudden sensorineural hearing loss reportedly arise from ischemic injury, pathological mechanism ischemia-reperfusion injury has not been fully elucidated. Recent animal studies have shed light on mechanisms injury. It will help in understanding pathology...
Considerable evidence of reactive oxygen species (ROS) involvement in cochlear hair cell (HC) loss, leading to acquired sensorineural hearing loss (SNHL), were reported. Cochlear synaptopathy between HCs and spiral ganglion neurons has been gathering attention as a HC precursor not detectable by normal auditory evaluation. However, the molecular mechanisms linking ROS with well relationship have elucidated. Here, we examined these linkages using NOX4-TG mice, which constitutively produce...
One drawback of existing artificial intelligence (AI)-based histopathological prediction models is the lack interpretability. The objective this study to extract p16-positive oropharyngeal squamous cell carcinoma (OPSCC) features in a form that can be interpreted by pathologists using AI model. We constructed model for predicting p16 expression dataset whole-slide images from 114 OPSCC biopsy cases. used clustering-constrained attention-based multiple-instance learning (CLAM) model, weakly...
Abstract DFNA1 (deafness, nonsyndromic autosomal dominant 1), initially identified as sensorineural hearing loss, has been associated with an additional symptom: macrothrombocytopenia. However, the timing of onset loss (HL) and thrombocytopenia not investigated, leaving it unclear which occurs earlier. Here, we generated a knock‐in (KI) mouse model, diaphanous‐related formin 1 ( DIA1 ) KIΔv3/KIΔv3 , in Aequorea coerulescens green fluorescent protein AcGFP ‐ tagged human DIA1(p.R1213X) was...
Abstract Malignant neoplasms arise within a region of chronic inflammation caused by tissue injuries. Inflammation is key factor involved in all aspects tumorigenesis including initiation, proliferation, invasion, angiogenesis, and metastasis. Interleukin-1 (IL-1) plays critical functions tumor development with influencing the microenvironment promoting cancer progression. However, mechanism continuous activation IL-1-mediated inflammatory pathway has not been fully elucidated. This study...
<p>The NF-κB reporter activation by IL-1 in SCC cell lines.</p>
<p>Promotion of NF-κB targets’ transcription by THG-1 in oncogenic RAS-transformed HaCaT cells.</p>
<p>Phosphorylation of THG-1 by EGF and IL-1 signaling.</p>