A5005728440- Genetic Neurodegenerative Diseases
- Neurogenetic and Muscular Disorders Research
- Nerve injury and regeneration
- Mitochondrial Function and Pathology
- Hereditary Neurological Disorders
- Amyotrophic Lateral Sclerosis Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Sarcoidosis and Beryllium Toxicity Research
- Diabetes Treatment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Neurological disorders and treatments
- Metabolism and Genetic Disorders
- Peripheral Neuropathies and Disorders
- Neurological diseases and metabolism
- Voice and Speech Disorders
- Botulinum Toxin and Related Neurological Disorders
- Blood Pressure and Hypertension Studies
- Parkinson's Disease Mechanisms and Treatments
- Mycobacterium research and diagnosis
- Neurobiology of Language and Bilingualism
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Muscle Physiology and Disorders
- Tuberculosis Research and Epidemiology
- Diabetes Management and Research
- Medical Imaging and Pathology Studies
Nagoya University
2003-2025
Aichi Gakuin University
2015-2025
Kitasato University Hospital
2025
Niigata University
1999-2024
Niigata City General Hospital
2024
Niigata Institute of Technology
2020-2023
Google (United States)
2021
University of Tsukuba
2020
Wakayama Medical University
2015-2017
Kyoto University
1992-2014
Diffuse panbronchiolitis (DPB) is a chronic inflammatory disease of the airways with high rate mortality despite treatment combination antibiotics and use supportive therapy such as oxygen administration. Low-dose erythromycin (EM) (400 to 600 mg/d) has been found improve survival patients DPB, most DPB in Japan have treated this regime since 1984. The purpose study was evaluate effects on Japan. We compared rates 498 after dividing them into three groups according date their first medical...
Presented here was an outline of fatal myocardial sarcoidosis in Japan based on 42 autopsy cases. The incidence, clinical features, pathological findings (particularly the distribution sarcoid lesions various organs, and gross as well histological patterns have been reviewed. ratio to total number deaths is higher than that other countries it appears characteristic Japanese disease occurs predominantly after fourth decade females. Only 12% cases are diagnosed exactly. Conduction disturbances...
Familial amyotrophic lateral sclerosis (FALS)-linked mutations in copper-zinc superoxide dismutase (SOD1) cause motor neuron death through one or more acquired toxic properties. We analyzed the molecular mechanism underlying degeneration transgenic mouse model expressing SOD1 gene with G93A mutation. Using cDNA microarray, differentially expressed genes were identified spinal cords of mice, 30 being elevated and seven decreased. microarray analysis to monitor expression during...
Abstract The causative pathomechanism of sporadic amyotrophic lateral sclerosis (ALS) is not clearly understood. Using microarray technology combined with laser‐captured microdissection, gene expression profiles degenerating spinal motor neurons isolated from autopsied patients ALS were examined. Gene was quantitatively assessed by real‐time reverse transcription polymerase chain reaction and in situ hybridization. Spinal showed a distinct profile the whole ventral horn. Three percent genes...
Late-onset type I familial amyloid polyneuropathy (FAP TTR Met30) cases unrelated to endemic foci in Japan show clinical features setting them apart from early-onset foci.To compare pathologic between the early- and late-onset types.Pathologic findings FAP Met30 with onset before age 50 relation (11 cases) were compared those 11 later-onset foci.Sural nerve biopsy specimens showed predominantly small-fiber loss cases; variable fiber size distribution, axonal sprouting, relatively preserved...
<h3>Objective</h3> The objective of this study was to elucidate the natural history late-onset transthyretin Val30Met-associated familial amyloid polyneuropathy (FAP ATTR Val30Met) in non-endemic areas. <h3>Methods</h3> authors retrospectively assessed development major clinical landmarks and abnormalities nerve conduction cardiac examination indices 50 patients with an age onset older than years no relationship endemic foci. <h3>Results</h3> Once neuropathic process initiated, sensory motor...
Amyotrophic lateral sclerosis (ALS) is a progressive paralytic disorder resulting from the degeneration of motor neurons in cerebral cortex, brainstem, and spinal cord. The cytopathological hallmark remaining ALS presence ubiquitylated inclusions consisting insoluble protein aggregates. In this paper we report that Dorfin, RING finger-type E3 ubiquitin ligase, predominantly localized inclusion bodies familial with copper/zinc superoxide dismutase (SOD1) mutation as well sporadic ALS. Dorfin...
<h3>Objectives</h3> To elucidate the phenotypes and pathophysiology of speech voice disorders in Parkinson9s disease (PD) with subthalamic nucleus deep brain stimulation (STN-DBS). <h3>Methods</h3> We conducted a cross-sectional study on 76 PD patients treated bilateral STN-DBS (PD-DBS) 33 medically (PD-Med). Speech functions, electrode positions, motor function cognitive were comprehensively assessed. Moreover, functions compared between on-stimulation off-stimulation conditions 42 PD-DBS...
Abstract Purpose To evaluate the accuracy of various claims‐based definitions diabetes‐related complications (coronary artery disease [CAD], heart failure, cerebrovascular and dialysis). Methods We evaluated data on 1379 inpatients who received care at Niigata University Medical & Dental Hospital in September 2018. Manual electronic medical chart reviews were conducted for all patients with regard to used as gold standard. Sensitivity, specificity, positive predictive value (PPV)...
Tofogliflozin, a highly selective inhibitor of sodium/glucose cotransporter 2 (SGLT2), induces urinary glucose excretion (UGE), improves hyperglycemia and reduces body weight in patients with Type diabetes (T2D). The mechanisms tofogliflozin on reduction were investigated detail obese diabetic animal models.Diet-induced (DIO) rats KKAy mice (a mouse model obesity) fed diets containing tofogliflozin. Body weight, composition, biochemical parameters metabolic evaluated.In DIO was administered...
Phylogenetic relationships among 20 species-group taxa of Mustelidae, representing Mustelinae (Mustela, Martes, Gulo), Lutrinae (Enhydra), and Melinae (Meles), were examined using nucleotide sequences the nuclear interphotoreceptor retinoid binding protein (IRBP) mitochondrial cytochrome b genes. Neighbor-joining maximum-parsimony phylogenetic analyses on these genes separately combined conducted. While IRBP performed better than in recovering more-inclusive clades, demonstrated more...
This study was conducted to determine if there is an association between shift work and risk factors for coronary heart disease (CHD) in Japanese mate blue-collar workers. Health check-up data on serum lipid concentration anthropometric indices of 33 three-shift workers 27 two-shift were compared with those day The average years age the 34.5 (SD=7.1) 32.7 (SD=7.6), respectively. Serum total cholesterol levels three-shift, 5.70 (SD=1.19) mmol/l, 4.81 (SD=1.01) 4.98 (SD=0.95) respectively,...
It has recently been shown that an insertion (I)/deletion (D) polymorphism exists in the angiotensin-converting enzyme (ACE) gene, and this affects serum ACE level. There are three genotypes: DD, DI, II, with level highest intermediate lowest II. In present investigation of possible significance for sarcoidosis, a total 207 patients 314 normal control subjects were examined. no significant differences I/D ratio genotype distribution between two groups, variation organ involvement (i.e., eye,...
<h3>Objective:</h3> This study aimed to explore the reliability and validity of tongue pressure measurement as a quantitative evaluation swallowing function in patients with spinal bulbar muscular atrophy (SBMA). <h3>Methods:</h3> enrolled 47 genetically confirmed SBMA 38 age- sex-matched healthy controls. In both groups we measured using an intraoral probe assessed questionnaires that evaluated functions. We then analyzed relationship between pressure, functional scales, muscle weakness...
Abstract Following recent genome wide association studies (GWAS), significant genetic associations have been identified for several genes with nonsyndromic cleft lip or without palate (CL(P)). To replicate two of these GWAS signals, we investigated the role common and rare variants in PAX7 VAX1 genes. TaqMan genotyping was carried out SNPs transmission disequilibrium test (TDT) performed to linkage each population. Direct sequencing around 1,326 individuals European Asian ancestry done. The...
Background Machine learning (ML) algorithms have been widely introduced to diabetes research including those for the identification of hypoglycemia. Objective The objective this meta-analysis is assess current ability ML detect hypoglycemia (ie, alert coinciding with its symptoms) or predict before symptoms occurred). Methods Electronic literature searches (from January 1, 1950, September 14, 2020) were conducted using Dialog platform that covers 96 databases peer-reviewed literature....
To determine the impact of metabolic syndrome (MetS) and/or dysfunction-associated fatty liver disease (MAFLD), which are pathophysiologically similar and include insulin resistance, on development new-onset cardiovascular with without type 2 diabetes according to sex.This study included 570,426 individuals a history who were enrolled in nationwide claims database from 2008 2016 classified by presence or absence MetS MAFLD stratified sex. The index was used that required diagnosis MAFLD....