A5105885983- Neuroendocrine regulation and behavior
- Magnetic Properties and Applications
- Neuroscience of respiration and sleep
- Magnetic Properties of Alloys
- Cerebrovascular and Carotid Artery Diseases
- Microstructure and Mechanical Properties of Steels
- Intracranial Aneurysms: Treatment and Complications
- Renal cell carcinoma treatment
- Prostate Cancer Diagnosis and Treatment
- Magnetic properties of thin films
- Circadian rhythm and melatonin
- Bladder and Urothelial Cancer Treatments
- Sleep and Wakefulness Research
- Metallurgical and Alloy Processes
- Vibration and Dynamic Analysis
- Stress Responses and Cortisol
- melanin and skin pigmentation
- Regulation of Appetite and Obesity
- Neuropeptides and Animal Physiology
- Prostate Cancer Treatment and Research
- Acute Ischemic Stroke Management
- Olfactory and Sensory Function Studies
- Composite Structure Analysis and Optimization
- Receptor Mechanisms and Signaling
- Renal and related cancers
Sendai Medical Center
2018-2024
National Hospital Organization
2023-2024
Tohoku University
2008-2023
Tohoku University Hospital
2023
Sendai City Hospital
2021-2023
Sendai Red Cross Hospital
2023
KKR Tohoku Kosai Hospital
2023
Tohoku Rosai Hospital
1999-2023
Jikei University School of Medicine
2020
The Japanese Society of Gastroenterological Surgery
2020
Microphthalmia-associated transcription factor (Mitf) plays a critical role in the development of neural crest-derived melanocytes. Here, we show that exogenously added Wnt-3a protein, an intercellular signaling molecule, up-regulates expression endogenous melanocyte-specific Mitf (Mitf-M) mRNA cultured The promoter humanMITF gene (MITF-M promoter) contains functional LEF-1-binding site, which is bound vitro by LEF-1 and confers preferential on reporter melanocytes melanoma cells, as judged...
Although ischemia-reperfusion of mouse kidney is known to cause severe renal failure due tubular cell death, the exact cellular mechanism responsible for this phenomenon not clear. To investigate spatial and temporal development death role Fas/APO-1/CD95 (Fas) in process, left vessels were occluded a group mice 30, 60, or 120 min followed by reperfusion 24 h (n = 4 each group). Analysis isolated DNA agarose-gel electrophoresis revealed typical ladder pattern bands consisting multiples 180...
Waardenburg syndrome type 2 (WS2) is associated with heterozygous mutations in the gene encoding microphthalmia-associated transcription factor (MITF) and characterized by deafness hypopigmentation due to lack of melanocytes inner ear skin. Melanocyte-specific MITF isoform (MITF-M) essential for melanocyte differentiation transcriptionally induced Wnt signaling that mediated β-catenin LEF-1. Here we show MITF-M transactivates its own promoter (Mpromoter) interacting LEF-1, as judged...
Although cerebral hyperperfusion after carotid endarterectomy (CEA) often impairs cognitive function, MRI does not always demonstrate structural brain damage associated with postoperative impairment. The purpose of the present study was to determine whether cortical neural loss, which can be detected by (123)I-iomazenil single-photon emission CT, is CEA and it correlates impairment.In 60 patients undergoing for ipsilateral internal artery stenosis (>70%), blood flow measured using...
Melanocyte and retinal pigment epithelium (RPE) specifically express tyrosinase other melanin‐producing enzymes. Microphthalmia‐associated transcription factor (Mitf), encoded at the mouse microphthalmia locus, regulates development survival of many cell types, including melanocyte RPE. MITF, human homolog Mitf, consists least four isoforms with distinct amino‐termini, referred to as A, MITF‐C, MITF‐H, MITF‐M. MITF‐M is exclusively expressed in melanocytes melanoma cells, thus represents...
The domain structure of an amorphous Fe80P13C7 alloy ribbon produced by the centrifugal solidification technique was investigated using magnetic powder pattern technique. Two different types domains (a maze and a 180°-domain) were observed on specimen surface. relationship between magnetization process also investigated. results showed that some 180°-walls, which ran nearly parallel to long axis ribbon, caused hysteresis in curve, while responsible for difficulty obtaining saturation...
The active form of vitamin D (1,25-dihydroxy-vitamin D3) is known to increase fast-type myosin heavy chain expression in differentiated myogenic cell lines. mechanisms for this effect are not fully understood. aim study was determine the role signals transmitted through receptor (VDR) during differentiation myoblasts.Electroporation used introduce VDR siRNA molecules into C2C12 and G8 murine myoblast Gene protein profiles VDR-gene silenced cells were analyzed vitro.Suppressing by RNA...
Adverse effects of intravenous acetazolamide administration for evaluation cerebrovascular reactivity using brain perfusion single-photon emission computed tomography (SPECT) were prospectively investigated in 100 patients with major cerebral artery, atherosclerotic, and steno-occlusive diseases. All underwent two SPECT studies (with without challenge) at an interval 2 or 3 days, received a questionnaire immediately after each study, returned the answered within 7 days study. None studied...
The effect of acupuncture on adrenocortical hormone production in adult female albino rabbits New Zealand strain was investigated. There significant increase compared to the control cortisol and corticosterone following application at locus Tsu-San-Li. In non-locus group, such treatment resulted only a transient raise followed by fall corticosterone. Acupuncture with electric current for 1 hour proved be unique that it gave rise no biphasic change 14C uptake steroids. These results indicate...
Magnetization measurements of α-phase Fe-Mn alloys, in which manganese concentration is extended up to 11 at% by cold-working techniques, have been made from liquid He temperature room temperature. The magnetic moment decreases linearly with increasing and assuming that the iron atom constant at 2.217 µ B , one obtains be 0.8 . On basis spin wave theory, exchange intergral J stiffness D are estimated precision magnetization low temperatures.
Waardenburg syndrome (WS) is characterized by deafness and hypopigmentation because of the lack melanocytes in inner ear skin. WS type 2 associated with mutations gene encoding microphthalmia‐associated transcription factor (MITF) that required for melanocyte differentiation. MITF consists multiple isoforms different N‐termini, one which exclusively expressed melanocytes, named MITF‐M. Its N‐terminus encoded exon 1M under regulation melanocyte‐specific (M) promoter. Here we identify a distal...