A5062896136- Knee injuries and reconstruction techniques
- Sports injuries and prevention
- Total Knee Arthroplasty Outcomes
- Sinusitis and nasal conditions
- Head and Neck Surgical Oncology
- Ear Surgery and Otitis Media
- Ear and Head Tumors
- Lower Extremity Biomechanics and Pathologies
- Nasal Surgery and Airway Studies
- Inflammatory mediators and NSAID effects
- Hearing, Cochlea, Tinnitus, Genetics
- Oral and Maxillofacial Pathology
- Asthma and respiratory diseases
- Shoulder Injury and Treatment
- Neuroscience of respiration and sleep
- Vestibular and auditory disorders
- Analytical Methods in Pharmaceuticals
- Cardiac electrophysiology and arrhythmias
- Antiplatelet Therapy and Cardiovascular Diseases
- Tumors and Oncological Cases
- Immune Response and Inflammation
- Tendon Structure and Treatment
- Obstructive Sleep Apnea Research
- Allergic Rhinitis and Sensitization
- Synthesis and Reactions of Organic Compounds
Kanazawa Municipal Hospital
2015-2025
Nihon University
2025
Kyushu University
2023-2024
Kyowa Kirin (Japan)
2005-2024
Shizuoka General Hospital
2012-2024
Japan Medical Association
2024
Kanazawa University
2015-2023
Asanogawa General Hospital
2022-2023
Sydney Orthopaedic Research Institute
2019-2023
Surugadai Nihon University Hospital
2021
Several described growth factors influence the proliferation and regeneration of intestinal epithelium. Using a transgenic mouse model, we identified human gene, R-spondin1, with potent specific proliferative effects on crypt cells. Human R-spondin1 (hRSpo1) is thrombospondin domain-containing protein expressed in enteroendocrine cells as well epithelial various tissues. Upon injection into mice, induced rapid onset cell involving beta-catenin stabilization, possibly by process that distinct...
Tau proteins are a class of low molecular mass microtubule-associated that specifically expressed in the nervous system. A cDNA clone adult rat tau was isolated and sequenced. To analyze functions vivo, we carried out transfection experiments. fibroblast cell line, which transfected with cDNA, three bands tau, while six were brain. After dephosphorylation, one disappeared, demonstrating directly phosphorylation involved multiplicity tau. Morphologically, observed thick bundle formation...
FGF23 suppresses both serum phosphate and 1,25-dihydroxyvitamin D [1,25D] levels in vivo. Because 1,25D itself is a potent regulator of metabolism, it has remained unclear whether FGF23-induced changes metabolism were caused by 1,25D-independent mechanism. To address this issue, we intravenously administered recombinant to vitamin receptor (VDR) null (KO) mice as rapid bolus injection evaluated the early effects FGF23. Administration further decreased level VDR KO mice, accompanied reduction...
In mammals, female development has traditionally been considered a default process in the absence of testis-determining gene, Sry. Recently, it documented that gene for R-spondin1 (RSPO1), novel class soluble activator Wnt/beta-catenin signaling, is mutated two Italian families with female-to-male (XX) sex reversal. To elucidate role Rspo1 as candidate female-determining mouse model, we generated Rspo1-null (Rspo1(-/-)) mice and found Rspo1(-/-) XX displayed masculinized features including...
The R-spondin (Rspo) protein family is a recently described group of four distinct human secreted proteins. Reported activities for Rspo proteins include essential roles in vertebrate development and their ligand-type overlap substantially with those the canonical Wnt ligands that both signaling result activation beta-catenin. In general functional screen using transgenic mouse models, we identified R-spondin1 (hRspo1) as potent specific mitogen gastrointestinal epithelium demonstrated...
Graft-versus-host disease (GVHD) is a major complication of allogeneic bone marrow transplantation (BMT), and damage to the gastrointestinal (GI) tract plays critical role in amplifying systemic disease. Intestinal stem cells (ISCs) play pivotal not only physiological tissue renewal but also regeneration intestinal epithelium after injury. In this study, we have discovered that pretransplant conditioning regimen damaged ISCs; however, ISCs rapidly recovered restored normal architecture...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhomactin A; a novel PAF antagonist from marine fungus Phoma spMichihiro Sugano, Aiya Sato, Yasuteru Iijima, Takeshi Oshima, Kouhei Furuya, Harumitsu Kuwano, Tadashi Hata, and Hiroyuki HanzawaCite this: J. Am. Chem. Soc. 1991, 113, 14, 5463–5464Publication Date (Print):July 1, 1991Publication History Published online1 May 2002Published inissue 1 July...
Renal intra-arterial administration of rat atrial extracts elicits a concentration dependent renal vasodilation (independent prostaglandin or dopamine release) in anesthetized rats. The do not alter skeletal musculature (hindlimb) vascular resistance systemic arterial blood pressure. high molecular weight peptide fraction obtained by gel filtration, reduces intra-arterially only after proteolytic activation (in vitro) following intravenous (i.e., vivo activation) administration. low the...
ObjectiveThe optimal anterolateral procedure to control rotational laxity of the knee is still unknown. The objective was compare ability five procedures performed in combination with anterior cruciate ligament reconstruction (ACLR) restore native kinematics setting a deficient (ACL) and structures.MethodsA controlled laboratory study using 10 fresh-frozen cadaveric whole lower limbs intact iliotibial band. Kinematics from 0° 90° flexion were recorded motion analysis three-dimensional (3D)...
We evaluated the clinical efficacy of endonasal endoscopic sinus surgery (ESS) in patients with asthma associated chronic sinusitis. Twenty-one (13 men and 8 women) from 27 to 72 years old were enrolled this study. All had sinus-related symptoms for more than 3 months computed tomographic evidence paranasal opacification. Fifteen underwent bilateral ESS under local anesthesia, 6 other without controls. The preoperative postoperative periods assessed via a questionnaire. period prior was...
Human CYP3A is the most abundant P450 isozyme present in human liver and small intestine, metabolizes around 50% of medical drugs on market. The subfamily comprises four members (CYP3A4, CYP3A5, CYP3A7, CYP3A43) encoded chromosome 7. However, transgenic mouse lines carrying entire cluster have not been constructed because limitations conventional cloning techniques. Here, we show that introduction a artificial (HAC) containing genomic locus recapitulates tissue- stage-specific expression...
Research Article| January 01 1961 Mechanism of transaminase action T. Oshima; Oshima 1Department Biophysics and Biochemistry, Faculty Science, University Tokyo, Japan Search for other works by this author on: This Site PubMed Google Scholar N. Tamiya 2School Medicine, Tokyo Medical Dental University, Biochem J (1961) 78 (1): 116–119. https://doi.org/10.1042/bj0780116 Connected Content A correction has been published: Views Icon Article contents Figures & tables Video Audio Supplementary Data...
The mechanism of macrolide therapy in chronic sinusitis patients is unclear. authors studied the effect macrolides on interleukin (IL)-8 secretion from cultured human nasal epithelial cells. Epithelial cells harvested polyps with were primary-cultured, and secreted IL-8 culture media was measured by enzyme immunoassay. considerable amounts constitutively response to lipopolysaccharide. significantly inhibited 10(-5) M erythromycin, clarithromycin, roxithromycin, josamycin. 10(-6)...
Connexin 31 (C×31) mutations cause an autosomal dominant form of high-frequency hearing loss. The immunohistochemical localization C×31 in mouse cochlea was studied at different ages between 0 and 60 days after birth (DAB). C×31-like immunoreactivity detected fibrocytes spiral ligament limbus 12 DAB, gradually enhanced with the increase age reached adult pattern on DAB. Immunoreactivity decreased from basal to apical turn all developmental stages. mRNA also identified by RT-PCR. distribution...
Objectives: Evaluation of the effect conservative and surgical treatment in patients with patulous Eustachian tube (PET) associated habitual sniffing. Study Design: Retrospective case review. Setting: University hospital otolaryngology department. Patients: Ninety-seven (23.4%) 414 PET were found to have sniffing alleviate uncomfortable aural symptoms. Of these, 38 habit selected. Interventions: Conservative intervention included instructions stop nasal instillation saline. Surgical...
ObjectivesGiven the common occurrence of residual laxity and re-injury post anterior cruciate ligament reconstruction (ACLR), additional anterolateral procedures are increasingly used in combination with an ACLR. Despite perception that there is a risk over-constraining lateral tibiofemoral (LTF) compartment, potentially leading to osteoarthritis, assessment on their effect intra-articular compartment pressures still lacking. Our objective was therefore, through pilot biomechanical study,...
High-resolution endoscopes and the advent of endoscopic instruments for sinus surgery provide surgeons with excellent endonasal visualization access to orbital walls.To demonstrate repair floor blowout fractures through an intranasal approach that allows fracture elevation content using a balloon catheter without external incision.This study was retrospective analysis 11 patients who underwent surgical from September 1994 June 1997. There were 10 male 1 female patient, aged 12 32 years (mean...