A5022470892- Nanoparticles: synthesis and applications
- 3D Printing in Biomedical Research
- Silk-based biomaterials and applications
- Pharmacogenetics and Drug Metabolism
- Advanced Drug Delivery Systems
- Heavy Metal Exposure and Toxicity
- Air Quality and Health Impacts
- Advanced Nanomaterials in Catalysis
- Bone Tissue Engineering Materials
- Nanoparticle-Based Drug Delivery
- Drug-Induced Hepatotoxicity and Protection
- Meat and Animal Product Quality
- Drug Transport and Resistance Mechanisms
- Microplastics and Plastic Pollution
- Protein Hydrolysis and Bioactive Peptides
- Biochemical effects in animals
- Epigenetics and DNA Methylation
- Drug Solubulity and Delivery Systems
- Marine Biology and Environmental Chemistry
- Phytochemical compounds biological activities
- Multiple and Secondary Primary Cancers
- Pituitary Gland Disorders and Treatments
- Protein Interaction Studies and Fluorescence Analysis
- Nanoplatforms for cancer theranostics
- Cancer Treatment and Pharmacology
National Nanotechnology Center
2015-2025
National Science and Technology Development Agency
2013-2025
Chiba University
2007-2012
Objective: The purpose of the study is to evaluate hepatoprotective effects Phikud Navakot (PN) extract against H2O2-induced oxidative stress in HepG2 cells. Methods: cells were treated with concentrations PN up 1 mg/ml prior incubation H2O2. Cell viability and ROS generation assessed by MTT DCFH-DA assays, respectively. Oxidative defense mechanisms investigated measuring glutathione levels activities antioxidant enzymes. Expression Nrf2 HO-1 proteins western blot analyses. Results: results...
Silver nanoparticles (AgNPs) are widely used in industry, consumer products, and medical appliances due to their efficient antimicrobial properties. However, information on environmental toxicity bacterial impact of these particles is not completely elucidated. Results showed that AgNPs produced growth inhibition oxidative stress bacteria Escherichia coli (gram negative) Staphylococcus aureus positive), with half-maximal inhibitory concentrations (IC50) 12 7 mg/L, respectively. Surprisingly,...
Human CYP3A is the most abundant P450 isozyme present in human liver and small intestine, metabolizes around 50% of medical drugs on market. The subfamily comprises four members (CYP3A4, CYP3A5, CYP3A7, CYP3A43) encoded chromosome 7. However, transgenic mouse lines carrying entire cluster have not been constructed because limitations conventional cloning techniques. Here, we show that introduction a artificial (HAC) containing genomic locus recapitulates tissue- stage-specific expression...
Of late, air pollution in Asia has increased, particularly built-up areas due to rapid industrialization and urbanization. The present study sets out examine the impact that can have on health of people living inner city Bangkok, Thailand. Consequently, 2021, fine particulate matter (PM2.5) coarse (PM10) chemical composition sources are evaluated at three locations Bangkok. To identify possible such particulates, therefore, principal component analysis (PCA) technique is duly carried out. As...
The high antibacterial and antiviral performance of synthesized copper(I) oxide (Cu2O) incorporated in zeolite nanoparticles (Cu-Z) was determined. Various Cu contents (1-9 wt %) solutions were loaded the matrix under neutral conditions at room temperature. All Cu-Z showed selectivity cuprous oxide, as confirmed by X-ray diffraction (XRD) photoelectron spectroscopy (XPS) analysis. An advantage prepared over pristine Cu2O its thermal stability. 7 9 % (07Cu-Z 09Cu-Z) exhibited best activities...
Potential use of a quaternized chitosan (MW 600 kDa) with 65% 3-chloro-2-hydroxypropyltrimethylammonium (600-HPTChC65) as an absorptive enhancer was investigated in Caco-2 monolayers. 600-HPTChC65 (0.005% w/v) quickly reduced transepithelial electrical resistance (TEER) to the maximum level 40 min full recovery within 6 h after removal. Its TEER reduction corresponded increased FD4 transport across monolayers and disrupted localization tight junction proteins ZO-1 occludin at cell borders....
Silk sericin (SS) from the Bombyx mori silk cocoons has received much attention biomedical scientists due to its outstanding properties, such as antioxidant, antibacterial, UV-resistant, and ability release moisturizing factors. Unmodified SS does not self-assemble strongly enough be used a hydrogel wound dressing. Therefore, there is need for suitable stabilization techniques interlink peptide chains or strengthen their structural cohesion. Here, we reported method form...
The development of different chitosan derivatives for medical applications has increased recently. Among these derivatives, quaternized was designed to improve the solubility in biological fluids oral drug delivery while retaining cationic character mucoadhesion. However, biocompatibility on human intestine is unknown. In this study, we aimed examine potential effects intestinal barrier, terms cell proliferation and differentiation, using Caco-2 line as an vitro model. lower degree...
We investigated cellular uptake behavior and biological responses of spherical fibrous titanate nanomaterials in human monocyte THP-1 cells. Two nanofibers (TiNFs), namely TF-1 TF-2, were synthesized from anatase TiO2 nanoparticles (TNPs) via hydrothermal treatment. The TiNFs TNPs thoroughly characterized for their size, crystallinity, surface area pH. (∼2 µm length) was amorphous with an acidic surface, while TF-2 (∼7 brookite a basic surface. results demonstrated that none these resulted...
Dynamic gut-on-a-chip platform allows better recreation of the intestinal environment in vitro compared to traditional static cell culture. However, underlying mechanism is still not fully discovered. In this study, shear stress behavior a device with porous membrane subjected peristalsis motion numerically investigated using CFD simulation for three different pore sizes and two pattern layouts. The results reveal that, stationary microchannel, average on approximately 15% greater than that...
Organ-on-a-chip allows dynamic microenvironment of the actual organ to be simulated in vitro.In this study, CFD simulation is used investigate behaviors fluid flow and shear stress due effect a transversely deforming membrane caused by cyclic deformation microchannel sidewalls gut-on-a-chip device.The result reveals that varies linearly along length microchannel.The average per cycle approximately three times greater than stationary amplitude frequency also significantly affect behaviors.The...