A5034517308- Hearing, Cochlea, Tinnitus, Genetics
- Sinusitis and nasal conditions
- Head and Neck Surgical Oncology
- Vestibular and auditory disorders
- Allergic Rhinitis and Sensitization
- Neuroscience of respiration and sleep
- Asthma and respiratory diseases
- Hearing Loss and Rehabilitation
- Nasal Surgery and Airway Studies
- Connexins and lens biology
- Salivary Gland Tumors Diagnosis and Treatment
- Olfactory and Sensory Function Studies
- Ear Surgery and Otitis Media
- Tracheal and airway disorders
- Ear and Head Tumors
- Obstructive Sleep Apnea Research
- Biochemical Analysis and Sensing Techniques
- Ion Channels and Receptors
- Oral and Maxillofacial Pathology
- Head and Neck Cancer Studies
- Ion channel regulation and function
- Voice and Speech Disorders
- Otolaryngology and Infectious Diseases
- Head and Neck Anomalies
- Bone Tumor Diagnosis and Treatments
Juntendo University
2016-2025
Koto Hospital
2024
Tokyo Metropolitan Geriatric Hospital
2022
Juntendo University Hospital
2008-2021
Japan Society of Chemotherapy
2015-2020
Kitasato University
2020
Juntendo University Nerima Hospital
2020
Mejiro University
2020
Inpex (Japan)
2018
Juntendo University Shizuoka Hospital
2007-2017
Abstract Background Chronic rhinosinusitis ( CRS ) can be classified into with nasal polyps w NP and without s ). displays more intense eosinophilic infiltration the presence of Th2 cytokines. Mucosal eosinophilia is associated severe symptoms often requires multiple surgeries because recurrence; however, even in ECRS ), clinical course variable. In this study, we wanted to set objective criteria for diagnosis refractory . Methods This was a retrospective study conducted by 15 institutions...
DFN3, an X chromosome-linked nonsyndromic mixed deafness, is caused by mutations in the BRN-4 gene, which encodes a POU transcription factor. Brn-4-deficient mice were created and found to exhibit profound deafness. No gross morphological changes observed conductive ossicles or cochlea, although there was dramatic reduction endocochlear potential. Electron microscopy revealed severe ultrastructural alterations cochlear spiral ligament fibrocytes. The findings suggest that these fibrocytes,...
Japanese patients with chronic rhinosinusitis nasal polyps (CRSwNP), differing from European and U.S. patients, are suggested to show two distinct phenotypes: Th2-polarized Th1-shifted immunity. The purpose of this study was conduct clinical subgrouping CRSwNP based on inflammatory cell infiltration, which evaluated supported by backgrounds immunological characteristics.A cross-sectional study.One hundred thirty were classified the infiltration eosinophils neutrophils in polyps....
ObjectiveTo provide an evidence-based recommendation for the management of olfactory dysfunction in accordance with consensus reached by Subcommittee Japanese Clinical Practice Guideline Rhinologic Society.MethodsSeven clinical questions (CQs) regarding were formulated subcommittee dysfunction. We searched literature published between April 1990 and September 2014 using PubMed, Cochrane Library, Ichushi Web databases. The main search terms "smell disorder," "olfactory dysfunction," loss,"...
Hereditary deafness affects about 1 in 2000 children and mutations the GJB2 gene are major cause various ethnic groups. encodes connexin26, a putative channel component cochlear gap junction. However, pathogenesis of hearing loss caused by remains obscure. The generation mouse model to study function connexin26 during has been hampered fact that Gjb2 knockout mice embryonic lethal. To establish viable we generated transgenic expressing mutant with R75W mutation was identified deaf family...
Abstract Objectives/Hypothesis: Eosinophilic chronic rhinosinusitis (CRS) is characterized by the accumulation of numerous eosinophils in sinus mucosa and nasal polyps, which are frequently difficult to control, even with surgery. The present study was designed evaluate expression localization eotaxins, well known be potent selective chemoattractants for CRS. Study Design: Randomized study. Methods: patients were classified into eosinophilic noneosinophilic groups. Histopathological profiles...
Interleukin (IL)-17A is a highly inflammatory cytokine with robust effect on stromal cells in many tissues. Although IL-17A known to be associated lung disorders by triggering an accumulation of neutrophils, the upper airway still uncertain. The expression and its role were investigated nasal polyps chronic rhinosinusitis asthma.IL-17A was detected immunohistochemistry quantitative real-time RT-PCR. cellular source examined double staining EG2, CD4 neutrophil elastase. tissue remodeling...
Hearing loss is the most widespread sensory disorder, with an incidence of congenital genetic deafness 1 in 1600 children. For many ethnic populations, prevalent form caused by recessive mutations gene gap junction protein, beta 2, 26 kDa (GJB2), which also known as connexin (Cx26). Despite this knowledge, existing treatment strategies do not completely recover speech perception. Here we used a delivery system to rescue hearing mouse model Gjb2 deletion. Mice lacking Cx26 are characterized...
In order to minimize surgical stress and preserve organs, endoscopic or robotic surgery is often performed when conducting head neck surgery. However, it impossible physically touch tumors observe diffusely invaded deep organs through the procedure of visualize safely resect even in these cases, we propose using an indocyanine green (ICG) fluorescence method for navigation cancer.To determine optimum time tumor resection after administration ICG based on investigation dynamic imaging.Nine...
Hereditary deafness affects approximately 1 in 2,000 children. Mutations the gene encoding cochlear gap junction protein connexin 26 (CX26) cause prelingual, nonsyndromic and are responsible for as many 50% of hereditary cases certain populations. Connexin-associated is thought to be result defective development auditory sensory epithelium due connexion dysfunction. Surprisingly, CX26 deficiency not compensated by closely related CX30, which abundantly expressed same cells. Here, using two...
We evaluated the clinical efficacy of endonasal endoscopic sinus surgery (ESS) in patients with asthma associated chronic sinusitis. Twenty-one (13 men and 8 women) from 27 to 72 years old were enrolled this study. All had sinus-related symptoms for more than 3 months computed tomographic evidence paranasal opacification. Fifteen underwent bilateral ESS under local anesthesia, 6 other without controls. The preoperative postoperative periods assessed via a questionnaire. period prior was...
Background. Patients with IgA nephropathy (IgAN) often show aggravation of renal injury macroscopic hematuria after mucosal infections, especially tonsillitis. We previously demonstrated the important role Toll-like receptor 9 (TLR9) activation in pathogenesis murine IgAN. Moreover, a single nucleotide polymorphism (SNP) TLR9 was significantly associated pathological severity human In this study, we investigated correlations between tonsillar messenger RNA expression, SNP genotypes and...
Mutations in the gap junction β2 (GJB2) gene, which encodes connexin 26, are leading cause of genetic deafness. These mutations characterized by degeneration and fragmentation junctions plaques (GJPs) composed 26. Dominant-negative GJB2, such as R75W, syndromic hearing loss palmoplantar keratoderma. We previously reported that R75W mutation, a single-base substitution where C is replaced T, causes GJPs. Therefore, an adenine base editor (ABE), enables A-to-G conversions, can potentially be...
Patients with obstructive sleep apnea syndrome (OSAS) have characteristic dentofacial features, but the sites of obstruction differ greatly. The purpose this study was to investigate characteristics patients OSAS respect sites. subjects consisted 30 Japanese men divided into 3 groups 10 each. One group had at retropalatal and retroglossal region (Rp + Rg group), a second third due tonsillar hypertrophy (tonsillar group). To identify Rp groups, dynamic magnetic resonance imaging (MRI) used....
Study Objectives:To evaluate the morphological features of mandible and volume upper airway soft tissues in determining anatomical risk factors for Japanese male patients with obstructive sleep apnea hypopnea syndrome (OSAHS).
The effects of streptomycin and kanamycin on the goldfish's saccular microphonic potentials were examined following their local application with a perfusion technique. results obtained compared those other drugs.Streptomycin suppressed microphonics only when they administered intraluminally to sacculus but showed almost no effect extraluminally.Metabolic inhibitors (cyanide, azide, DNP), quinine, procaine also microphonics, but, unlike kanamycin, there was difference in if luminal side or...
Abstract Background Dysphagia is a serious complication of chemoradiotherapy (CRT) in patients with head and neck cancer. Approximately 20% to 30% who have dysphagia require feeding tubes. The purpose this study was evaluate the impact prophylactic swallowing exercises on function. Methods Fifty‐one advanced oropharyngeal, hypopharyngeal, laryngeal cancers were included study. Twenty‐one performed Shaker exercise 30 practiced traditional Mendelsohn maneuvers (control group). Before after...
High-resolution endoscopes and the advent of endoscopic instruments for sinus surgery provide surgeons with excellent endonasal visualization access to orbital walls.To demonstrate repair floor blowout fractures through an intranasal approach that allows fracture elevation content using a balloon catheter without external incision.This study was retrospective analysis 11 patients who underwent surgical from September 1994 June 1997. There were 10 male 1 female patient, aged 12 32 years (mean...
Dynamic changes in the pharyngeal airway of patients with obstructive sleep apnea syndrome (OSAS) were evaluated by quantitating findings real-time imaging performed during wakefulness and spontaneous means dynamic magnetic resonance (MRI). Six OSAS 3 non-OSAS subjects, selected prospectively randomly, underwent polysomnography MRI. The cross-sectional areas soft palate oropharynx anterior-posterior dimensions seen calculated US National Institutes Health software. On basis a case control...
Effects of long-term low-dose macrolide administration were studied in patients with chronic sinusitis. Twelve non-allergic sinusitis orally given 150 mg roxithromycin once a day without other treatments. The underwent computed tomography before and after the treatment, paranasal sinus aeration was analyzed quantitatively. number neutrophils nasal smear semiquantitatively assessed on grading scale, IL-8 concentration discharge measured by enzyme immunoassay. all four sinuses significantly...
The cytosolic free calcium concentration ([Ca2+]i) isolated from the cochlear outer hair cell (OHC) of guinea pig was measured using microfluorimetric imaging technique and effects radicals were investigated. Hypoxanthine (HX) plus xanthine oxidase (XO) induced a rise in [Ca2+]i presence external Ca2+. Elimination Ca2+ (pCa = 7) did not show an increase [Ca2+]i, indicating that increased is dependent on elevation by HX-XO reduced addition superoxide dismutase or nifedipine but catalase. A...