A5086606656- Sinusitis and nasal conditions
- Head and Neck Surgical Oncology
- Nasal Surgery and Airway Studies
- Olfactory and Sensory Function Studies
- Allergic Rhinitis and Sensitization
- Ear Surgery and Otitis Media
- Oral and Maxillofacial Pathology
- Vascular Anomalies and Treatments
- Biochemical Analysis and Sensing Techniques
- Tracheal and airway disorders
- Advanced Chemical Sensor Technologies
- Salivary Gland Tumors Diagnosis and Treatment
- Facial Nerve Paralysis Treatment and Research
- Ear and Head Tumors
- Infectious Diseases and Mycology
- Head and Neck Cancer Studies
- Cancer Diagnosis and Treatment
- Vestibular and auditory disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Vascular Malformations Diagnosis and Treatment
- Otitis Media and Relapsing Polychondritis
- Adenosine and Purinergic Signaling
- Facial Trauma and Fracture Management
- Vascular Malformations and Hemangiomas
- Cerebral Venous Sinus Thrombosis
Hyogo University
2022-2025
Hyogo Medical University
2014-2023
Hyogo Earthquake Memorial 21st Century Research Institute
2022
Jikei University School of Medicine
2021
Ramathibodi Hospital
2021
Mahidol University
2021
Primary Source
2017
University of San Francisco
2010
Scottish Intercollegiate Guidelines Network
2010
Newcastle College
2010
ObjectiveTo provide an evidence-based recommendation for the management of olfactory dysfunction in accordance with consensus reached by Subcommittee Japanese Clinical Practice Guideline Rhinologic Society.MethodsSeven clinical questions (CQs) regarding were formulated subcommittee dysfunction. We searched literature published between April 1990 and September 2014 using PubMed, Cochrane Library, Ichushi Web databases. The main search terms "smell disorder," "olfactory dysfunction," loss,"...
Strong eosinophil infiltration in chronic rhinosinusitis with nasal polyp (CRSwNP) is highly associated recalcitrance and higher recurrence rate after surgery. The prevalence of eosinophilic CRSwNP (ECRS) increasing Asian countries including Japan. Benralizumab a humanized anti-IL-5R alpha monoclonal antibody that depletes eosinophils by antibody-dependent cell-mediated cytotoxicity.To assess the efficacy safety benralizumab patients ECRS.This phase II, randomized, double-blind,...
The P2X3 receptor is a ligand-gated cation channel activated by the binding of extracellular adenosine 5′-triphosphate (ATP), an agent that has been suggested to have role in nociceptive pathway after tissue and nerve injury. After peripheral injury, both down regulation up sensory ganglion neurons observed. purpose this study was examine precise mRNA expression primary We used two injury models rat, transection tibial common peroneal nerves infraorbital nerve, observed dorsal root (DRG)...
Menthol and many of its derivatives produce profound sensory mental effects. The receptor for menthol has been cloned named cold- menthol-sensitive receptor-1 (CMR1) or transient potential channel M8 (TRPM8) receptor. Using a dorsal root ganglion (DRG) horn (DH) coculture system as model the first synapse in CNS, we studied effects on synaptic transmission underlying mechanisms. We found that increased frequency miniature EPSCs (mEPSCs). persisted under an extracellular Ca 2+ -free condition...
Background: The self-administered odour questionnaire (SAOQ), consisting of 20 odours familiar to Japanese people, is proposed as a scoring system for the quantitative evaluation sense smell. We examined correlations between SAOQ and standard olfactory test covered by insurance in Japan evaluated usefulness patients with dysfunction (OD). Methodology: Data from 3048 undergoing treatment OD June 2005 September 2021 were retrospectively analysed. causative diseases identified. Correlations...
Introduction. We retrospectively analysed the background and treatment effects of patients who improved with steroid alone those in whom steroids were ineffective required dupilumab or revision functional endoscopic sinus surgery (FESS) for postoperative recurrence eosinophilic chronic rhinosinusitis (ECRS). The objective this study was to determine factors influencing effectiveness evaluate outcomes alternative treatments, such as FESS. Methods. Between April 2007 July 2021, 118 adult ECRS...
Using spinal cord slice preparations and patch-clamp recordings in lamina II V regions, we tested a hypothesis that P2X receptor subtypes differentially modulate glutamate release from primary afferent terminals innervating different sensory regions. We found activation of receptors by α,β-methylene-ATP increased onto >80% DH neurons both However, two distinct types modulation, transient long-lasting enhancement were observed. In recordings, >70% the modulation was transient. contrast,...
IgA nephropathy (IgAN) has been considered to have a relationship with infection in the tonsil, because IgAN patients often manifest macro hematuria just after tonsillitis. In terms of oral-area infection, red complex periodontal bacteria (Porphyromonas gingivalis (P. gingivalis), Treponema denticol (T. denticola) and Tannerella forsythia forsythia)) is important, but between these remains unknown. this study, prevalence tonsil was compared tonsillitis patients. The pathogenicity induced by...
This study aimed to determine the predictors of disease progression after functional endoscopic sinus surgery in patients with chronic rhinosinusitis.A total 281 adult rhinosinusitis who underwent primary bilateral between 2007 and 2017 had at least 12 months follow-up evaluation were examined. Patients divided into eosinophilic (n = 205) non-eosinophilic groups 76). In order adverse factors, post-operative appearance scores analysed relation pre- intra-operative findings using multiple...
Abstract Objective This study aimed to propose appropriate management for odontogenic chronic rhinosinusitis. Method Thirty-one adult patients with rhinosinusitis undergoing maxillary extraction were retrospectively analysed. Patients ( n = 21) and without 10) oroantral fistula on computed tomography classified. Functional endoscopic sinus surgery was performed when sinusitis did not improve after extraction. The critical indicators surgical requirement in the of Results Sinusitis...
P2X receptors have been suggested to be expressed on the central terminals of Aδ-afferent fibers innervating dorsal horn lamina V and play a role in modulating sensory synaptic transmission. These widely thought 2 + 3 receptors. However, we recently found that receptor-mediated modulation transmission is not inhibited by trinitrophenyl-adenosine triphosphate (TNP-ATP), potent antagonist 1 , homomers, heteromers. To provide direct evidence for presence TNP-ATP-resistant primary afferent...
The preoperative bone conduction level provides not only prognostic information but also on the mobility of stapes in tympanosclerosis. surgical results depend upon mobility.We aimed to evaluate operative findings and hearing tympanosclerosis involving ossicular chain, order understand pathophysiology establish better treatment tympanosclerosis.Between January 1998 March 2004, 29 patients (29 ears) with chain underwent tympanoplasty at our hospital. Patients myringosclerosis only, or an...
Most of the clinical cases experienced taste disturbance after stapes surgery, and in a few this persisted for long time. The animal experiment suggested role geniculate ganglion (GG) cells nerve generation.To clinically examine disorder its recovery surgery experimentally demonstrate GG.Taste function preservation chorda tympani (CTN) was prospectively investigated with questionnaire electrogustometry (EGM). Further, expression neurotrophic factors GG injury CTN examined by situ...
Olfactory dysfunctions (OD) and taste (TD) are widely recognized as characteristic symptoms of COVID-19; however, the frequency mode occurrence has varied depending on viral mutation. The prevalence characteristics OD/TD in Japan have not been definitively investigated. purpose this study is to assess during Alpha variant epidemic, measure symptom prolongation at 6 months 1 year later following initial infection.Patients treated for COVID-19 between February May 2021 were evaluated provided...
The eustachian tube (ET) has two important functions, ventilation and clearance of the middle ear. We evaluated ET ventilator function by sonotubometry inflation-deflation test that are widely used today, saccharin test. Results both tests were compared with surgical outcomes, assessed which was more closely related to outcomes.Prospective case series.A single university hospital.One hundred four ears 95 patients chronic otitis media perforation underwent type I tympanoplasty.Based on test,...
Surgical treatment for inferior turbinate (IT) is selected to treat severe allergic rhinitis (AR) that unresponsive conservative treatment. This study aimed determine the clinical effects of outpatient sub- mucosal IT surgery (OSITS) on patients with AR. Between January 2008 and August 2012, 95 AR who underwent OSITS at Department Otolaryngology, Hyogo College Medicine, were retrospectively analyzed. There 53 men 42 women. Their mean age was 27 years (11–75 years). bilaterally performed...