A5082992290- Olfactory and Sensory Function Studies
- Sinusitis and nasal conditions
- Head and Neck Surgical Oncology
- Asthma and respiratory diseases
- Microbial Natural Products and Biosynthesis
- Advanced Chemical Sensor Technologies
- Oral and Maxillofacial Pathology
- Synthesis and Biological Activity
- Carbohydrate Chemistry and Synthesis
- Biochemical Analysis and Sensing Techniques
- Bone Tumor Diagnosis and Treatments
- Allergic Rhinitis and Sensitization
- Respiratory and Cough-Related Research
- Nasal Surgery and Airway Studies
- Proteoglycans and glycosaminoglycans research
- Eosinophilic Esophagitis
- Neuroendocrine Tumor Research Advances
- IL-33, ST2, and ILC Pathways
- Tracheal and airway disorders
- Chemical Synthesis and Analysis
- Tumors and Oncological Cases
- Helicobacter pylori-related gastroenterology studies
- Infectious Diseases and Mycology
- Inflammatory mediators and NSAID effects
- Nerve injury and regeneration
Nishinomiya Municipal Central Hospital
2023
Shiga University of Medical Science
2011-2022
Hokkaido University
2021
Mental Research Institute
2017
Environmental Research Institute
2017
Kyorin University
2016
Helsinki University Hospital
2016
University of Helsinki
2016
University of Amsterdam
2016
Academic Medical Center
2016
ObjectiveTo provide an evidence-based recommendation for the management of olfactory dysfunction in accordance with consensus reached by Subcommittee Japanese Clinical Practice Guideline Rhinologic Society.MethodsSeven clinical questions (CQs) regarding were formulated subcommittee dysfunction. We searched literature published between April 1990 and September 2014 using PubMed, Cochrane Library, Ichushi Web databases. The main search terms "smell disorder," "olfactory dysfunction," loss,"...
Thrombin, the effector enzyme of coagulation system, has been reported to promote inflammatory responses in nasal diseases through its protease-activated receptors (PARs). Chronic rhinosinusitis (CRS) is characterized by increased deposition extracellular matrix proteins, tissue remodeling, and formation polyps. The role thrombin chronic inflammation-associated remodeling still not appraised. This study was conducted elucidate pathogenesis CRS.Nasal secretion collected from patients with CRS...
Background Predominant eosinophil infiltration and tissue remodeling are common characteristics of chronic airway inflammation such as nasal polyposis bronchial asthma. This study was designed to elucidate the role eosinophils in inflammation; eosinophil–epithelial interactions were examined by coculture epithelial cell line NCI-H292 with eosinophilic EoL-1 or human blood eosinophils. Methods The coculture-induced production MUC5AC mucin, platelet-derived growth factor AB (PDGF-AB), vascular...
Activation of the coagulation system with an increase in thrombin generation is involved pathogenesis tissue remodeling chronic rhinosinusitis (CRS). Tissue factor (TF) important protein for initiation extrinsic pathway, and TF pathway inhibitor (TFPI) a regulator TF-induced coagulation. This study was conducted to elucidate roles TFPI CRS.Tissue localization TF, TFPI, fibrin determined by immunostaining nasal polyps inferior turbinates obtained during endonasal surgery patients CRS polyp...
Background Mucus hypersecretion and neutrophil infiltration are important characteristics of airway inflammation. Epidermal growth factor receptor (EGFR) transactivation induces mucus inflammatory cytokine secretion from epithelial cells. To elucidate the roles EGFR in inflammation, vitro effects on mucin production interleukin (IL) 8 cultured cells vivo rat nasal mucosa tyrosine kinase inhibitor AG1478 were examined. Methods The treatment NCI-H292 lipopolysaccharide (LPS) induced or tumor...
Background Recent experiments have revealed that valproic acid (VPA), a histone deacetylase inhibitor, has neuroregenerative effects in rodent models of spinal cord and optic nerve injury. VPA potential to provide new therapeutic strategy for sensorineural olfactory dysfunction. To elucidate the on regeneration sensory neurons, we examined vivo oral administration recovery from methimazole-induced degeneration neuroepithelium mice. Methods Male ICR mice (10 weeks old) were intraperitoneally...
The aims of the present study were to clarify time-course olfactory recovery and prognostic factors in PIOD patients treated with Toki-shakuyaku-san (TSS).A retrospective cohort was conducted by reviewing patients' medical records. This included who received TSS or a combination zinc sulfate. Olfactory function examined T&T olfactometer at each 3-monthly follow-up visit. Patients normal mild dysfunction excluded. Gender, age, treatment, duration disease until first visit scores analyzed as...
Heparin is one of the most important anticoagulant drugs. It has been known that heparin also possesses anti-inflammatory activities. Mucus hypersecretion an characteristic airway inflammation. However, little about regulatory effects on mucus in epithelial cells. To elucidate function cells, we examined vivo and neutrophil infiltration rat nasal epithelium. We vitro mucin production IL-8 secretion from cultured human cells.We induced hypertrophic metaplastic changes goblet cells epithelium...
Aquaporins (AQPs) are water-specific membrane channel proteins that regulate water homeostasis for cells and organisms. The purpose of this study was to elucidate the role AQPs 1, 2, 3, 4, 5 in normal diseased human nasal mucosa.Nasal polyps were obtained from eight patients with chronic rhinosinusitis (CRS). Inferior turbinate tissue five allergic rhinitis (AR) six septal deviation (controls). Expression AQP1-5 mRNA examined using reverse transcriptase-polymerase chain reaction (RT-PCR)...
Abstract Background Ezrin, ERK, STAT3, and AKT are proteins that overexpressed in various types of cancer, although their expressions tongue cancer has received less focus. This study aimed to address associations between the expression levels these with characteristics tumor patient survival. Methods We performed immunohistochemical staining ezrin, tumors from patients carcinoma situ (CIS, n = 17) squamous cell (SCC, 46). Statistical differences SCC versus CIS cohorts were estimated by...
Objectives: The resolution of inflammation is an active process controlled by several anti-inflammatory and pro-resolution mediators. Lipoxin A4, endogenous lipid mediator, a potential mediator that could attenuate inflammation. This study was conducted to elucidate the role lipoxin A4 in upper airway Methods: Nasal secretions were collected from patients with chronic rhinosinusitis nasal polyposis, allergic rhinitis, control subjects. concentration measured enzyme-linked immunosorbent...
Heparin is a potential anti-inflammatory drug for allergic airway inflammation. To elucidate the effects of heparin on inflammation, we examined in vivo antigen-induced mucus hypersecretion and infiltration eosinophils neutrophils nasal epithelium sensitized rats. We induced hypertrophic metaplastic changes goblet cells ovalbumin (OVA)-sensitized rats by intranasal challenge with OVA. The instillation low molecular weight (LMWH; 1–1000 IU/0.1 ml) production eosinophil/neutrophil were...
The antibiotic validamycin A (1a) has been synthesized for the first time (as its undeca-O-acetate) by glycosylation of partially protected derivative (8) aglycone, validoxylamine (2a), with 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl chloride (11), followed deprotection, thereby establishing structure previously assigned. totally O-acetytated (19) 7-deoxyvalidemycin in a similar fashion.
An 80-year-old woman with rheumatoid arthritis during treatment etanercept, a tumor necrosis factor (TNF) inhibitor, showed swelling of the salivary glands and retroperitoneal fibrosis, which was diagnosed as IgG4-related disease. Although some reports have shown efficacy TNF inhibitors for disease or sometimes cause paradoxical reactions like psoriasis, mechanisms are considered to involve upregulation plasmacytoid dendritic cells IFN-α, is also common in patients This case report fibrosis...
内視鏡下に根治切除を行った鼻副鼻腔良性腫瘍23例, 悪性腫瘍4例について検討を加えた. 内視鏡下良性腫瘍切除の適応は鼻腔, 上顎洞内側壁, 篩骨洞, 蝶形骨洞前壁に存在し, 前頭洞, 上顎洞前壁, 蝶形骨洞, 眼窩, 翼口蓋窩へ腫瘍が大きく進展していない症例とした. 悪性腫瘍切除の適応は鼻腔, 鼻腔に面した副鼻腔壁に存在し, en bloc切除可能な小腫瘍で, 組織学的に低悪性度の症例とした. 良性腫瘍の組織型は内反性乳頭腫10例, 血管腫9例, 若年性血管線維腫2例, 多形腺腫1例, 線維腫1例であり, 悪性腫瘍では嗅神経芽細胞腫, 腺房細胞癌, 扁平上皮癌, 軟骨様脊索腫であった. 再発性内反性乳頭腫2例, 軟骨様脊索腫1例を除き, bloc切除が可能であった. 良性腫瘍では術後平均観察期間は21ヵ月で再発例はなかった. 悪性腫瘍では軟骨様脊索腫症例で術後早期に再発した. 内視鏡下にサルベージ手術を行い, 術後陽子線治療を行った. サルベージ手術後3年5ヵ月間再発を認めない. 術前塞栓術, 内視鏡下蝶口蓋動脈結紮術, レーザーを中心とした焼灼機器を使用することにより良性,...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthetic studies on the validamycins. 10. Total synthesis of DL-validoxylamines A and BSeiichiro Ogawa, Takao Yoshikazu Iwasawa, Tatsushi Toyokuni, Noritaka Chida, Tetsuo SuamiCite this: J. Org. Chem. 1984, 49, 14, 2594–2599Publication Date (Print):July 1, 1984Publication History Published online1 May 2002Published inissue 1 July 1984https://pubs.acs.org/doi/10.1021/jo00188a016https://doi.org/10.1021/jo00188a016research-articleACS...
A 75-year-old male was admitted to our hospital for severe nasal bleeding. He had undergone right nephrectomy 11 years previously renal cell cancer. metastatic clear carcinoma from the kidney identified in cavity. Computer tomography and magnetic resonance imaging showed large mass extending left cavity, maxillary sinus, ethmoid sphenoid optic nerve, pars petrosa of internal carotid artery. For treatment bleeding, packing arterial embolization were ineffective. However, radiotherapy (36Gy)...
Objective: To evaluate the effectiveness and usefulness of transnasal endoscopic surgery for treatment odontogenic maxillary cysts.Methods: Between February 2003 2008, was performed under general anesthesia in 13 patients (male 6 female 7, 19 to 75 years old) with cysts that extended sinus.Ten had a radicular cyst three dentigerous cyst.After resection anterior edge inferior turbinate, lateral wall nasal meatus opened.Then, sinus partially or completely removed endoscope.Results: The walls...