A5001367645- Sinusitis and nasal conditions
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Nasal Surgery and Airway Studies
- Head and Neck Surgical Oncology
- Pediatric health and respiratory diseases
- Infectious Diseases and Mycology
- IL-33, ST2, and ILC Pathways
- Cell Adhesion Molecules Research
- Respiratory and Cough-Related Research
- Hearing, Cochlea, Tinnitus, Genetics
- Global Healthcare and Medical Tourism
- Head and Neck Cancer Studies
- Osteomyelitis and Bone Disorders Research
- Mast cells and histamine
- Antifungal resistance and susceptibility
- Cytokine Signaling Pathways and Interactions
- Mycobacterium research and diagnosis
- Neonatal Respiratory Health Research
- Medical and Biological Sciences
- Ear Surgery and Otitis Media
- Inflammatory mediators and NSAID effects
- Ear and Head Tumors
- Biochemical Analysis and Sensing Techniques
- melanin and skin pigmentation
Toho University Ohashi Medical Center
2016-2025
Toho University
2016-2025
Jikei University School of Medicine
2002-2023
Stanford University
2023
Tokyo Medical Center
2023
Tohoku Medical and Pharmaceutical University
2015
Fukuoka University
2015
Osaka Prefectural Medical Center
2006
Kyoto University
2006
Kagoshima University
2006
Abstract Background Chronic rhinosinusitis ( CRS ) can be classified into with nasal polyps w NP and without s ). displays more intense eosinophilic infiltration the presence of Th2 cytokines. Mucosal eosinophilia is associated severe symptoms often requires multiple surgeries because recurrence; however, even in ECRS ), clinical course variable. In this study, we wanted to set objective criteria for diagnosis refractory . Methods This was a retrospective study conducted by 15 institutions...
Eosinophils and nasal polyps are believed to affect the surgical outcome of chronic rhinosinusitis (CRS). CRS is classified based on presence in western countries. The majority patients with (CRS NP) characterized by predominantly eosinophilic inflammation. However, Asian NP show characteristics indicative neutrophilic Therefore, eosinophils or more important for classification CRS?A prospective cohort study conducted from April 2007 March 2008 mucosal eosinophilia. recurrence rate was...
Endoscopic medial maxillectomy (EMM) is a safe and effective procedure for treatment of inverted papilloma (IP) originating from the maxillary sinus. However, EMM usually removes inferior turbinate nasolacrimal duct. The has critical function in conditioning nasal airflow, resection ducts risk epiphora. We developed newly derived surgical technique, endoscopic modified (EMMM), which enables preservation duct.A retrospective case series six patients with IP nine mucoceles sinus after...
Strong eosinophil infiltration in chronic rhinosinusitis with nasal polyp (CRSwNP) is highly associated recalcitrance and higher recurrence rate after surgery. The prevalence of eosinophilic CRSwNP (ECRS) increasing Asian countries including Japan. Benralizumab a humanized anti-IL-5R alpha monoclonal antibody that depletes eosinophils by antibody-dependent cell-mediated cytotoxicity.To assess the efficacy safety benralizumab patients ECRS.This phase II, randomized, double-blind,...
This randomised, double-blind, placebo-controlled, parallel-group, 52-week Phase III study (MERIT; NCT04607005) assessed mepolizumab efficacy and safety in patients with chronic rhinosinusitis nasal polyps (CRSwNP)/eosinophilic CRS (ECRS) Japan, Russia, China, for which data are limited.
Respiratory epithelial cells play important roles not only in host defense mechanisms, but also inflammatory responses. Inhaled corticosteroids are widely used for the treatment of patients with lung disorders, including asthma, chronic obstructive pulmonary disease, and sarcoidosis. Corticosteroids effectively reduce production mediators, such as cytokines chemokines. Although these molecules essential responses, there is no convincing evidence that inhaled increase susceptibility to lower...
Abstract Cochlear melanocytes are intermediate cells in the stria vascularis that generate endocochlear potentials required for auditory function. Human PAX3 mutations cause Waardenburg syndrome and abnormalities of skin retinal melanocytes, manifested as congenital hearing loss (~ 70%) hypopigmentation skin, hair eyes. However, underlying mechanism remains unclear. originated from Pax3 -traced melanoblasts Plp1 Schwann cell precursors, both which derive neural crest cells. Here, using a...
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The prevalence of patients with chronic rhinosinusitis (CRS) refractory to traditional therapy appears be on the increase. In these cases, CRS tends associated bronchial asthma (BA), especially, aspirin-intolerant (AIA). On other hand, arachidonic acid metabolites have been extensively investigated in pathogenesis BA. We sought assess role prostaglandin D2 (PGD2) and E2 (PGE2) recalcitrant pathophysiology CRS. Samples were prepared from nasal polyps mucosa 40 undergoing endoscopic sinus...
Abstract Background Deregulation of the EGFR signaling pathway is one most frequently observed genetic abnormalities that drives cancer development. Although mutations in downstream components pathway, including KRAS, BRAF and PIK3CA, have been reported numerous cancers, extensive mutation copy number analysis these genes clinical samples has not performed for head neck squamous cell carcinoma (HNSCC). Methods We examined alterations PIK3CA 115 specimens HNSCC obtained from surgically...
Interleukin (IL)-33, which is a member of the IL-1 family cytokines, now recognized as an important contributor to Th2-type immune responses. We examined whether levels IL-33 in sera and nasal secretions are upregulated allergic rhinitis (AR) patients, we tested for correlations between level parameters atopy symptom score.The study included 24 Japanese cedar pollinosis patients (12 male 12 female with mean age 47.7 years) history moderate-to-severe AR, 14 house-dust-mite-sensitized AR (9 5...
Sinus fungus ball is defined as noninvasive chronic fungal rhinosinusitis occurring in immunocompetent patients with regional characteristics. The clinical and imaging characteristics of paranasal sinus were retrospectively investigated 104 Japanese patients. All underwent endoscopic surgery. Preoperative computed tomography (CT), magnetic resonance (MR) imaging, age, sex, chief complaint, causative fungus, outcome analyzed. Patients aged from 25 to 79 years (mean 58.8 years). Female...
GM3 synthase (ST3GAL5) is the first biosynthetic enzyme of a- and b-series gangliosides. Patients with deficiency suffer severe neurological disability deafness. Eight children (ages 4.1 ± 2.3 years) homozygous for ST3GAL5 c.694C>T had no detectable (a-series) or GD3 (b-series) in plasma. Their auditory function was characterized by absence middle ear muscle reflexes, distortion product otoacoustic emissions cochlear microphonics, as well abnormal brainstem responses cortical auditory-evoked...
Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is known to have 2 phenotypes in East Asia. Eosinophilic CRSwNP (ECRSwNP), defined as tissue eosinophilia and easily recurrent, distinguished from other non‐eosinophilic (NECRSwNP) types. However, the pathogenesis of each remains unclear. Methods Nasal polyp tissues ECRS (ECRSwNP) NECRS patients were obtained, their comprehensive gene expression profiles investigated by microarray analysis. Bioinformatics approaches (eg, Ingenuity...
Chronic rhinosinusitis (CRS) is a persistent inflammatory disease of various endotypes, including eosinophilic CRS (eCRS), which characterized by marked infiltration and high refractory rates despite treatment. Recent findings suggest the interaction between local IgE mast cells in nasal polyps (NPs) key to eCRS pathogenesis; however, details remain unclear. This study investigated involvement MS4A2, component receptor, pathogenesis eCRS. NP tissue samples were collected from 47 patients...
The pathophysiology of chronic rhinosinusitis (CRS) is not fully understood. In Europe and the United States, major subsets CRS classification are based on presence or absence polyps. Although nasal polyps (NPs) a critical factor, many other factors also contribute to pathogenesis CRS. aim this study was investigate diverse phenotypes using cluster analysis.This multicenter examining clinical data from patients treated at five hospitals. design retrospective analysis prospectively collected...
Patients undergoing endoscopic sinus surgery (ESS) are at risk of complications because the close proximity sinuses to orbit and anterior skull base. The aim this study was evaluate ESS identify patient characteristics that were factors for complications.We conducted a prospective 706 patients who underwent chronic rhinosinusitis. completed preoperative examinations included computed tomography, observation nasal polyps, tests comorbidities including asthma vascular disease. Perioperative...
Reverse transcription-quantitative polymerase chain reaction is a valuable and reliable method for gene quantification. Target expression usually quantified by normalization using reference genes (RGs), accurate critical producing data. However, stable RGs in nasal polyps sinonasal tissues from patients with chronic rhinosinusitis (CRS) have not been well investigated. Here, we used two-stage study design to identify RGs. We assessed the stability of 15 commonly candidate five...