A5047028269- Sinusitis and nasal conditions
- Nasal Surgery and Airway Studies
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Tracheal and airway disorders
- Obstructive Sleep Apnea Research
- Olfactory and Sensory Function Studies
- Cancer Immunotherapy and Biomarkers
- Neural and Behavioral Psychology Studies
- Cancer Diagnosis and Treatment
- Healthcare cost, quality, practices
- Venous Thromboembolism Diagnosis and Management
- 14-3-3 protein interactions
- Patient-Provider Communication in Healthcare
- Respiratory and Cough-Related Research
- Psychology of Moral and Emotional Judgment
- Spinal Hematomas and Complications
- Immunotherapy and Immune Responses
- Cardiac Health and Mental Health
- Neurosurgical Procedures and Complications
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Animal Genetics and Reproduction
- Pediatric health and respiratory diseases
- Stroke Rehabilitation and Recovery
- Neurobiology and Insect Physiology Research
Eastern Virginia Medical School
2019-2025
Kyushu University
2024
University of Calgary
2024
Tangshan Gongren Hospital
2020
Soochow University
2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2020
First Hospital of Shijiazhuang
2020
Creative Commons
2020
Peking Union Medical College Hospital
2020
North China University of Science and Technology
2020
This randomised, double-blind, placebo-controlled, parallel-group, 52-week Phase III study (MERIT; NCT04607005) assessed mepolizumab efficacy and safety in patients with chronic rhinosinusitis nasal polyps (CRSwNP)/eosinophilic CRS (ECRS) Japan, Russia, China, for which data are limited.
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a type 2 inflammatory disease high symptom burden and poor quality of life. Treatment options include recurrent surgeries and/or frequent systemic corticosteroids (SCS). Dupilumab, fully human monoclonal antibody, blocks the shared receptor component for interleukin-4 interleukin-13, key drivers 2-mediated inflammation. We report results pooled analyses from randomised, double-blind, placebo-controlled phase 3 studies (SINUS 24...
Loss of smell is one the most bothersome and difficult-to-treat symptoms in patients with severe chronic rhinosinusitis nasal polyps (CRSwNP).
Transcutaneous Electrical Acupoint Stimulation (TEAS), as a non-invasive treatment method, has been increasingly applied in the perioperative period due to its simplicity, non-invasiveness, and high patient acceptance. It shown certain effects reducing postoperative complications promoting recovery. This review summarizes research progress of TEAS analgesia, improvement neurocognitive disorders, immune function regulation, alleviation sleep disturbances, promotion recovery, organ protection,...
We have microinjected a mAb specifically directed to phosphatidylinositol 4,5-bisphosphate (PIP2) into one blastomere of two-cell stage Xenopus laevis embryos. This antibody binds endogenous PIP2 and reduces its rate hydrolysis by phospholipase C. Antibody-injected blastomeres undergo partial or complete arrest the cell cycle whereas uninjected sister divided normally. Since normally produces diacylglycerol (DG) inositol 1,4,5-triphosphate (Ins[1,4,5]P3), we attempted measure changes in...
In March 2023, the European Forum for Research and Education in Allergy Airways diseases (EUFOREA) organized its bi-annual Summit Brussels with expert panel members of EUFOREA, representatives EUFOREA patient advisory board, board management teams. Its aim was to define research, educational advocacy initiatives be developed by over next 2 years until 10th anniversary 2025. is an international non-for-profit organization forming alliance all stakeholders dedicated reducing prevalence burden...
Using double-barreled, Ca2(+)-sensitive microelectrodes, we have examined the characteristics of Ca2+ release by inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) in various layers Xenopus laevis eggs which organelles had been stratified centrifugation. Centrifugation living stratifies yet retains them normal cytoplasmic milieu. The local increase intracellular free each layer was directly measured under physiological conditions using theta-tubing, microelectrodes one barrel filled with sensor and...
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BACKGROUND: Temperature-controlled radiofrequency (TCRF) device treatment of nasal valve dysfunction (NVD) was superior to a sham procedure control in reducing the symptoms airway obstruction (NAO) this randomised controlled trial (RCT). METHODOLOGY: Two-year outcomes for 108 patients actively treated prospective, multicenter, patient-blinded RCT were used determine effect durability and changes medication/nasal dilator usage. A responder defined as ≥20% reduction NOSE score or ≥1 severity...
Background The level of physical activity (PA) among patients with coronary heart disease (CHD) living in Chinese communities who do not participate cardiac rehabilitation programs and the factors contributing to patient maintenance PA are unclear. Objective This cross-sectional study, guided by Transtheoretical Model, evaluated (1) CHD 12 months after hospital discharge (2) demographic, clinical, psychological characteristics associated PA. Methods A total 1162 completed 6 questionnaires at...
Temperature-controlled radiofrequency (TCRF) device treatment of nasal valve dysfunction (NVD) was superior to a sham procedure control in reducing the symptoms airway obstruction (NAO) this randomised controlled trial (RCT).
Background: Medico-legal complaints against physicians are a significant source of anxiety and could be associated with defensive medical practices that may correlate poor patient outcomes. Little is known about concerns brought to regulatory bodies courts dermatologists in Canada. Objective: To characterize factors contributing medico-legal Methods: The Canadian Medical Protective Association (CMPA) repository was queried for all closed cases involving over the past decade. Aggregate,...
Prof. Martin Wagenmann MD is presenting the data on behalf of all authors with their permissions. The abstract was previously presented at ERS2020, Eur Respir J. 2020;56(Suppl. 64):4616.
BACKGROUND: Loss of smell is one the most bothersome and difficult-to-treat symptoms in patients with severe chronic rhinosinusitis nasal polyps (CRSwNP). METHODOLOGY: SYNAPSE was a 52-week Phase III study 4-weekly mepolizumab (100 mg subcutaneously) plus standard care adults bilateral CRSwNP. This post hoc analysis assessed changes from baseline to end loss visual analogue scale (VAS) symptom score, stratified by several clinical characteristics. SinoNasal Outcomes Test (SNOT)-22 sense...