A5048354088- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Sinusitis and nasal conditions
- Dermatology and Skin Diseases
- Food Allergy and Anaphylaxis Research
- IL-33, ST2, and ILC Pathways
- Nasal Surgery and Airway Studies
- Health and Medical Studies
- Urticaria and Related Conditions
- Immunodeficiency and Autoimmune Disorders
- Otitis Media and Relapsing Polychondritis
- Inhalation and Respiratory Drug Delivery
- Respiratory and Cough-Related Research
- Drug-Induced Adverse Reactions
- Contact Dermatitis and Allergies
- Pediatric health and respiratory diseases
- Salivary Gland Tumors Diagnosis and Treatment
- Ear and Head Tumors
- COVID-19 Clinical Research Studies
- Oral Health Pathology and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Eosinophilic Esophagitis
- Head and Neck Surgical Oncology
- Ear Surgery and Otitis Media
- Sarcoidosis and Beryllium Toxicity Research
Technical University of Munich
2015-2024
Klinikum rechts der Isar
2015-2024
German Center for Lung Research
2015-2024
Helmholtz Zentrum München
2015-2024
München Klinik
2024
Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde
2011-2023
Helmholtz Association of German Research Centres
2021
Universitätsklinik für Hals-, Nasen- und Ohrenheilkunde
2018-2021
Praxis
2020
Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
2020
Allergen immunotherapy (AIT) is an effective treatment for allergic rhinoconjunctivitis (AR) with or without asthma. It important to note that due the complex interaction between patient, allergy triggers, symptomatology and vaccines used AIT, some patients do not respond optimally treatment. Furthermore, there are no validated generally accepted candidate biomarkers predictive of clinical response AIT. Clinical management receiving AIT efficacy in randomised controlled trials drug...
Abstract Nasal allergen challenge (NAC) is an important tool to diagnose allergic rhinitis. In daily clinical routine, experimentally, or when measuring therapeutic success clinically, nasal fundamental. It further one of the key diagnostic tools initiating specific immunotherapy. So far, national recommendations offered guidance on its execution; however, international divergence left many questions unanswered. These differences in literature caused EAACI initiate a task force answer unmet...
Severe chronic rhinosinusitis with nasal polyps (CRSwNP) is a debilitating disease significant impact on the quality of life (QoL). It typically characterized by type 2 inflammatory reaction and comorbidities such as asthma, allergies NSAID-Exacerbated Respiratory Disease (N-ERD). Here, European Forum for Research Education in Allergy Airway diseases discusses practical guidelines patients biologic treatment. Criteria selection who would benefit from biologics were updated. Guidelines are...
BackgroundIn the phase III SYNAPSE study, mepolizumab reduced nasal polyp (NP) size and obstruction in chronic rhinosinusitis with NP.ObjectiveWe sought to assess efficacy of patients from grouped by comorbid asthma, aspirin-exacerbated respiratory disease (AERD), baseline blood eosinophil count (BEC).MethodsSYNAPSE, a randomized, double-blind, 52-week study (NCT03085797), included severe bilateral NP eligible for surgery despite intranasal corticosteroid treatment. Patients received...
The persistently high prevalence of allergic diseases in Western industrial nations and the limited possibilities causal therapy make evidence-based recommendations for primary prevention necessary.
Nasal endoscopy is not only used for the diagnosis of chronic rhinosinusitis with nasal polyps (CRSwNP), but also monitoring response to therapy playing an important role in both daily practice and research. In contrast patient-reported outcomes, endoscopic polyp scoring by independent blinded readers objective measurement, influenced placebo effect. It safer cheaper compared computed tomography imaging therefore, better suited regular assessments extent disease. Since early 90s, a variety...
Severe chronic rhinosinusitis with nasal polyps (CRSwNP), a form of diffuse bilateral (usually type 2) CRS, is debilitating disease significant impact on quality life (QoL). With novel knowledge and treatment options becoming available, there growing need to update or revise key definitions enable communication across different specialties dealing agree goals care in CRSwNP. The European Forum for Research Education Allergy Airway diseases (EUFOREA) EPOS expert members discussed how measure...
Hundreds of plant species release their pollen into the air every year during early spring. During that period, allergic as well non-allergic patients frequently present to doctors with severe respiratory tract infections. Our objective was therefore assess whether may interfere antiviral immunity.We combined data from real-life human exposure cohorts, a mouse model and cell culture test our hypothesis.Pollen significantly diminished interferon-λ pro-inflammatory chemokine responses airway...
Interferon-γ (IFN-γ) and interleukin-4 (IL-4) are key effector cytokines for the differentiation of T helper type 1 2 (Th1 Th2) cells. Both induce fate-decisive transcription factors such as GATA3 TBX21 that antagonize polarized development opposite phenotypes by direct regulation each other's expression along with many other target genes. Although it is well established mesenchymal cells directly respond to Th1 Th2 cytokines, nature antagonistic programs in airway epithelial only partially...
The number of patients affected by allergies is increasing worldwide. resulting allergic diseases are leading to significant costs for health care and social systems. Integrated pathways needed enable comprehensive within the national ARIA (Allergic Rhinitis its Impact on Asthma) initiative develops internationally applicable guidelines respiratory diseases. serves improve with chronic In collaboration other international initiatives, associations patient organizations in field diseases,...
The outbreak of the SARS-CoV-2-induced coronavirus disease 2019 (COVID-19) pandemic re-shaped doctor-patient interaction and challenged capacities healthcare systems. It created many issues around optimal safest way to treat complex patients with severe allergic disease. A significant number are on treatment biologicals, clinicians face challenge provide care during pandemic. Uncertainty potential risks for these is related fact that exact sequence immunological events SARS-CoV-2 not known....
Summary Two employees of the National Health Service (NHS) in England developed severe allergic reactions following administration BNT162b2 vaccine against COVID-19 (coronavirus disease 2019). The British SmPC for already includes reference to a contraindication use individuals who have had an reaction or any its components. As precautionary measure, Medicines and Healthcare products Regulatory Agency (MHRA) has issued interim guidance NHS not vaccinate principle “patients with allergies”....
Monocyte-derived macrophages (MDM) drive the inflammatory response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and they are a major source of eicosanoids in airway inflammation. Here we report that MDM from SARS-CoV-2-infected individuals with mild disease show an transcriptional metabolic imprint lasts for at least 5 months after SARS-CoV-2 infection. convalescent showed downregulation pro-resolving factors increased production pro-inflammatory eicosanoids, particularly...
Hymenoptera venom (HV) is injected into the skin during a sting by such as bees or wasps. Some components of HV are potential allergens and can cause large local and/or systemic allergic reactions (SAR) in sensitized individuals. During their lifetime, ~ 3% general population will develop SAR following sting. This guideline presents diagnostic therapeutic approach to stings. Symptomatic therapy usually required after severe reaction, but specific diagnosis allergen immunotherapy (AIT) with...
BackgroundAllergen-specific immunotherapy (AIT) is a causative treatment in allergic airway disease, comprising long-term allergen administration and requiring three years of treatment. Mechanisms biomarkers that translate into clinical efficacy remain urgently needed.MethodsIn an exploratory observational allergy cohort we phenotyped 32 grass-pollen patients with hayfever undergoing AIT for over controls using local systemic samples ex vivo FACS, nasal transcriptomes vitro...
Abstract Background Chronic rhinosinusitis is regarded as a chronic airway disease. According to WHO recommendations, it may be risk factor for COVID‐19 patients. In most CRSwNP cases, the inflammatory changes affecting nasal and paranasal mucous membranes are type‐2 (T2) inflammation endotypes. Methods The current knowledge on treatment options CRS was analyzed by literature search in Medline, Pubmed, international guidelines, Cochrane Library Internet. Results Based literature,...
While several systemic immunomodulatory effects of allergen-specific immunotherapy (AIT) have been discovered, local anti-inflammatory mechanisms in the respiratory tract are largely unknown. We sought to elucidate and epithelial underlying a genome-wide approach.We induced sputum hay fever patients healthy controls during pollen peak season stratified by effective allergen or as untreated. Sputum was directly processed after induction subjected whole transcriptome RNA microarray analysis....