A5044753603- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Colorectal Cancer Screening and Detection
- Cardiac Valve Diseases and Treatments
- Dementia and Cognitive Impairment Research
- Gastric Cancer Management and Outcomes
- Acute Myocardial Infarction Research
- Genetic factors in colorectal cancer
- Transplantation: Methods and Outcomes
- S100 Proteins and Annexins
- Alzheimer's disease research and treatments
- Prostate Cancer Diagnosis and Treatment
- Cardiac Structural Anomalies and Repair
- Prostate Cancer Treatment and Research
- Neuroendocrine Tumor Research Advances
- Cancer, Lipids, and Metabolism
- Viral Infections and Immunology Research
- Cell Adhesion Molecules Research
- Peripheral Artery Disease Management
- Peptidase Inhibition and Analysis
- Cancer, Hypoxia, and Metabolism
- Diverticular Disease and Complications
- Coronary Artery Anomalies
- Growth Hormone and Insulin-like Growth Factors
- Monoclonal and Polyclonal Antibodies Research
Hospital Clínic de Barcelona
2016-2025
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2008-2024
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2008-2023
Universitat de Barcelona
2006-2023
Global Brain Health Institute
2022
Trinity College Dublin
2022
TD Bank
2022
University of Cologne
2018
Centro de Investigación Biomédica en Red
2014-2015
Cancer Clinic
2014
Abstract Nasal allergen challenge (NAC) is an important tool to diagnose allergic rhinitis. In daily clinical routine, experimentally, or when measuring therapeutic success clinically, nasal fundamental. It further one of the key diagnostic tools initiating specific immunotherapy. So far, national recommendations offered guidance on its execution; however, international divergence left many questions unanswered. These differences in literature caused EAACI initiate a task force answer unmet...
Rationale: We have previously identified six serum tumor markers (TMs) (carcinoembryonic antigen, carbohydrate antigen 15.3, squamous cell carcinoma–associated cytokeratin-19 fragment, neuron-specific enolase, and pro–gastrin-releasing peptide) related to the presence of lung cancer (LC).Objectives: To validate their individual performance in an independent cohort, explore if combined assessment (≥1 abnormal TM value) is a more accurate marker for LC presence.Methods: determined these TMs...
Blood-based biomarkers have emerged as minimally invasive options for evaluating cognitive impairment. Most studies to date assessed them in research cohorts, limiting their generalization everyday clinical practice. We evaluated diagnostic performance and applicability a prospective, real-world, memory clinic cohort.
Synaptic damage, axonal neurodegeneration, and neuroinflammation are common features in Alzheimer's disease (AD), frontotemporal dementia (FTD), Creutzfeldt-Jakob (CJD).Unicentric cohort of 353 participants included healthy control (HC) subjects, AD continuum stages, genetic FTD, FTD CJD. We measured cerebrospinal fluid neurofilament light (NF-L), neurogranin (Ng), 14-3-3, YKL-40 proteins.Biomarkers showed differences HC subjects versus AD, Disease groups differed between them except for...
Abstract Metalloproteinase 7 (MMP‐7) plays an important role in tumor growth, invasion and dissemination, is secreted to the media. Because of close implication MMP‐7 cancer biology, we sought define prognostic significance serum levels metastatic colorectal (CRC) explore its possible impact daily clinical practice. expression was determined by enzyme‐linked immunoabsorbent assay. We assessed 87 healthy controls, 96 patients with nonmetastatic CRC 120 advanced CRC. Clinical information...
The efficacy of oxaliplatin in cancer chemotherapy is limited by the development drug resistance. MMP7 has been related to loss tumor cell response cytotoxic agents although exact mechanism not fully understood. Moreover, an independent prognosis factor for survival patients with colorectal cancer. aim present study was analyze role and its cross-talk Fas/FasL system during acquisition resistance colon cells.For this purpose we have developed three different oxaliplatin-resistant lines...
Cancer may be diagnosed in advanced stages, when the patient has already developed metastasis, with symptoms that can also observed benign diseases. The objective of this study was to evaluate tumor marker sensitivity and specificity differential diagnosis patients suspected signs cancer. We studied 2.711 consecutive admitted Internal Medicine Department our hospital cancer; 1.240 had non-malignant processes 1.471 malignant disease. Determinations were considered positive for malignancy...
Background and study aims Serrated polyposis syndrome (SPS) is a high risk condition for colorectal cancer (CRC). Surveillance strategies patients with serrated lesions remain controversial. We aimed to evaluate diagnostic strategy detect SPS consistently during reassessment colonoscopy in proximal lesions. Methods This was retrospective of all individuals from fecal immunochemical test (FIT)-based CRC screening program (2010 - 2013) one or more ≥ 5 mm the sigmoid colon on baseline...
Early-onset Alzheimer's disease (EOAD) shows a higher burden of neuropsychiatric symptoms than late-onset (LOAD). We aim to determine the differences in severity and locus coeruleus (LC) integrity between EOAD LOAD accounting for stage.
The long-term clinical course and results of biopsies in 21 patients studied with monoclonal antimyosin antibodies more than 12 months after heart transplantation according to the presence degree antimyosin-antibody uptake is described. Eighteen men three women aged 20-52 years (39 +/- 9 years) were 12-40 (mean, 22 months) transplantation, followed for a mean 18 (10-28 months). number performed during follow-up was 102. Results showed normal studies nine abnormal patients. Myocyte damage...
%p2PSA and prostate health index (phi) has shown valuable results in the detection of cancer (PCa), improving prediction aggressiveness tumor. The goal present study was to evaluate phi PCa, estimating their relationship with PCa.A total 354 patients positive or negative prostatic biopsy were included. Prospectively, 150 enrolled 204 retrospectively proceeding from our serum bank.The best performance observed for phi, obtaining an AUC 0.723 0.732, respectively. highest specificity at...
Abstract The utility of faecal immunochemical tests (FIT) in assessment symptomatic patients with lower gastrointestinal symptoms has not been well explored. aims this study were to evaluate the diagnostic yield for advanced colorectal neoplasia (ACRN) using first two FIT samples (FIT/1) and higher concentration (FIT/max). Samples from consecutive bowel motions 208 who required colonoscopy analysed HM-JACKarc analyser (Kyowa Medex Co., Ltd., Tokyo, Japan). Patients categorised into groups:...
Abstract Prior studies have described distinct patterns of brain gray matter and white alterations in Alzheimer's disease (AD) frontotemporal lobar degeneration (FTLD), as well differences their cerebrospinal fluid (CSF) biomarkers profiles. We aim to investigate the relationship between early‐onset AD (EOAD) FTLD structural CSF biomarker levels. included 138 subjects (64 EOAD, 26 FTLD, 48 controls), all them with a 3T MRI scan available (the 42 amino acid‐long form amyloid‐beta protein...
Detection and treatment for rejection after transplantation are based on the identification of myocyte damage upon endomyocardial biopsy. Noninvasive detection such is possible with 111In-labeled monoclonal antimyosin antibodies (MAA). Although presence degree MAA uptake parallels activity detected by biopsy, relation between occurrence severe rejection-related complications has not been previously assessed.Two hundred forty-seven studies were performed coinciding biopsies in 52 patients...
<h3>Background & Aims</h3> An algorithm based on fecal levels of 2 microRNAs (miR-421 and miR-27a-3p), hemoglobin concentration, patient age sex can identify patients with advanced colorectal neoplasia. We investigated whether this algorithm, called miRFec, could increase effectiveness efficiency immunochemical test (FIT)-based cancer (CRC) screening programs. <h3>Methods</h3> obtained data samples from 767 persons a positive result the FIT who then underwent colonoscopy examination while...