A5027334000- Advanced Neuroimaging Techniques and Applications
- Neonatal and fetal brain pathology
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Fetal and Pediatric Neurological Disorders
- Birth, Development, and Health
- Neurological disorders and treatments
- Neuroscience and Neuropharmacology Research
- Genetic Neurodegenerative Diseases
- Alzheimer's disease research and treatments
- Medical Image Segmentation Techniques
- Pregnancy and preeclampsia studies
- Tensor decomposition and applications
- Health, Environment, Cognitive Aging
- Biochemical effects in animals
- Infant Development and Preterm Care
- MRI in cancer diagnosis
- Anesthesia and Neurotoxicity Research
- Vagus Nerve Stimulation Research
- Tryptophan and brain disorders
- Neural dynamics and brain function
- Metabolomics and Mass Spectrometry Studies
- Metabolism and Genetic Disorders
- Sleep and Wakefulness Research
- Medical Imaging and Analysis
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2016-2025
Hospital Clínic de Barcelona
2012-2024
University Medical Center Freiburg
2024
University of Freiburg
2024
Instituto de Investigaciones Biomédicas Sols-Morreale
2024
Centro Nacional de Biotecnología
2024
Medical University of South Carolina
2024
Biomedical Research Institute
2024
Universitat de Barcelona
2012-2022
Champalimaud Foundation
2022
Background Intrauterine growth restriction (IUGR) affects 5–10% of all newborns and is associated with a high risk abnormal neurodevelopment. The timing patterns brain reorganization underlying IUGR are poorly documented. We developed rabbit model allowing neonatal neurobehavioral assessment resolution diffusion magnetic resonance imaging (MRI). aim the study was to describe pattern functional correlates fetal induced by IUGR. Methodology/Principal Findings in 10 New Zealand rabbits ligation...
Animal models of Alzheimer's disease (AD) are essential to understanding the progression and development early biomarkers. Because AD has been described as a disconnection syndrome, magnetic resonance imaging (MRI)-based connectomics provides highly translational approach characterizing disruption in connectivity associated with disease. In this study, transgenic rat model (TgF344-AD) was analyzed describe both cognitive performance brain at an stage (5 months age) before significant...
Higher risk for long-term cognitive and behavioral impairments is one of the hallmarks extreme prematurity (EP) pregnancy-associated fetal adverse conditions such as intrauterine growth restriction (IUGR). While neurodevelopmental delay abnormal brain function occur in absence overt lesions, these have been recently associated with changes microstructural development. Recent imaging studies indicate connectivity, particular involving white matter fibers belonging to cortico-basal...
While individual cardiac myocytes only have a limited ability to shorten, the heart efficiently pumps large volume-fraction thanks cell organization in complex 3D fibre structure. Subclinical subtle structural remodelling is often present before symptoms arise. Understanding and early detection of these changes crucial for diagnosis prevention. Additionally, personalized computational modelling requires knowledge on multi-scale structure whole vessels.We developed rapid acquisition together...
Huntington’s disease (HD) is a neurological disorder characterized by motor disturbances. HD pathology most prominent in the striatum, central hub of basal ganglia. The cerebral cortex main striatal afferent, and progressive cortico-striatal disconnection characterizes HD. We mapped network dysfunction mice to ultimately modulate activity specific circuit ameliorate symptoms recover synaptic plasticity. Multimodal MRI vivo indicates thalamo-striatal functional deficits reduced...
Cerebral hypoperfusion induced by bilateral common carotid artery occlusion (BCCAo) in rodents has been proposed as an experimental model of white matter damage and vascular dementia. However, the histopathological behavioral alterations reported this are variable a full characterization dynamic is not available. Here we implemented longitudinal multimodal magnetic resonance imaging (MRI) design, including time-of-flight angiography, high resolution T1-weighted images, T2 relaxometry...
Background Intrauterine growth restriction (IUGR) affects 5–10% of all newborns and is associated with increased risk memory, attention anxiety problems in late childhood adolescence. The neurostructural correlates long-term abnormal neurodevelopment IUGR are unknown. Thus, the aim this study was to provide a comprehensive description functional near-term rabbit model (delivered at 30 days gestation) evaluate development quantitative imaging biomarkers based on diffusion magnetic resonance...
Early-onset Alzheimer's disease (EOAD) shows a higher burden of neuropsychiatric symptoms than late-onset (LOAD). We aim to determine the differences in severity and locus coeruleus (LC) integrity between EOAD LOAD accounting for stage.
Background: Alzheimer's disease is characterized by progressive cognitive decline and neurodegeneration, with reserve playing a key role in mitigating impact. Cognitive stimulation has been suggested as non-pharmacological approach to enhance delay deterioration, but its underlying mechanism remains be fully understood. This study investigates the effects of pre-amyloid intervention on brain connectivity, memory, synaptic plasticity neuroinflammation aged TgF344-AD rats, considering...
Rabbit brain has been used in several works for the analysis of neurodevelopment. However, there are not specific digital rabbit atlases that allow an automatic identification regions, which is a crucial step various neuroimage analyses, and, instead, manual delineation areas interest must be performed order to evaluate structure. For this reason, we propose atlas based on magnetic resonance imaging, including both structural and diffusion weighted, can parcellation brain. Ten individual...
Adverse conditions during fetal life have been associated to both structural and functional changes in neurodevelopment from the neonatal period adolescence. In this study, connectomics was used assess evolution of brain networks infancy early Brain network reorganization over time subjects who had suffered adverse perinatal is characterized related cognition. Three cohorts prematurely born infants children (between 28 35 weeks gestational age), including individuals with a birth weight...
Abstract Objectives To conduct brainstem MRI shape analysis across neurodegenerative parkinsonisms and control subjects (CS), along with its association clinical cerebrospinal fluid (CSF) correlates. Methodology We collected demographic variables, performed planimetric analyses, determined CSF neurofilament-light chain (NfL) levels in 84 participants: 11 CS, 12 Parkinson’s disease (PD), 26 multiple system atrophy (MSA), 21 progressive supranuclear palsy (PSP), 14 corticobasal degeneration...
Primary brain neoplasms are associated with elevated mortality and morbidity rates. Brain tumour surgery aims to achieve maximal resection while minimizing damage healthy tissue. Research on Neuromodulation Induced Cortical Prehabilitation (NICP) has highlighted the potential, before neurosurgery, of establishing new connections transfer functional activity from one area another. Nonetheless, neural mechanisms underlying these processes, particularly in context space-occupying lesions,...
Introduction Neurosurgery for brain tumors needs to find a complex balance between the effective removal of targeted tissue and preservation surrounding areas. Neuromodulation-induced cortical prehabilitation (NICP) is promising strategy that combines temporary inhibition critical areas (virtual lesion) with intensive behavioral training foster activation alternative resources. By progressively reducing functional relevance areas, goal facilitate resection reduced risks neurological...