A5004889443- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Stroke Rehabilitation and Recovery
- Neurological Disease Mechanisms and Treatments
- MRI in cancer diagnosis
- Cerebrospinal fluid and hydrocephalus
- Cerebrovascular and genetic disorders
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Health and Disease Prevention
- Intracranial Aneurysms: Treatment and Complications
- Neurological Disorders and Treatments
- Fetal and Pediatric Neurological Disorders
- Genetic Associations and Epidemiology
- Epigenetics and DNA Methylation
- Cerebral Venous Sinus Thrombosis
- Neurosurgical Procedures and Complications
- Medical Image Segmentation Techniques
- Retinal Imaging and Analysis
- Alzheimer's disease research and treatments
University of Edinburgh
2016-2025
UK Dementia Research Institute
2017-2025
NHS Lothian
2013-2025
Edinburgh Royal Infirmary
1988-2025
University of Lausanne
2024
University of Oslo
2024
University College London
2011-2024
University of Bristol
2024
University of Glasgow
1839-2024
Hospital de Sant Pau
2024
This article represents the update of European Stroke Initiative Recommendations for Management. These guidelines cover both ischaemic stroke and transient attacks, which are now considered to be a single entity. The covers referral emergency management, Unit service, diagnostics, primary secondary prevention, general treatment, specific treatment including acute management complications, rehabilitation.
In this cross-sectional study, we tested the construct validity of a "total SVD score," which combines individual MRI features small-vessel disease (SVD) in one measure, by testing associations with vascular risk factors and stroke subtype.We analyzed data from patients lacunar or nondisabling cortical 2 prospective studies. Brain was rated for presence lacunes, white matter hyperintensities, cerebral microbleeds, perivascular spaces independently. The each feature summed an ordinal "SVD...
Enlarged perivascular spaces in the brain are common but generally overlooked and of uncertain pathophysiology. They may reflect underlying cerebral small vessel disease. We determined whether enlarged were associated with lacunar stroke subtype white matter hyperintensities, markers established disease.We prospectively recruited patients acute ischemic or cortical stroke. Age-matched nonstroke control subjects also recruited. rated basal ganglia centrum semiovale 0 to 4 (0=none, 4=>40) on...
Age-associated disease and disability are placing a growing burden on society. However, ageing does not affect people uniformly. Hence, markers of the underlying biological process needed to help identify at increased risk age-associated physical cognitive impairments ultimately, death. Here, we present such biomarker, 'brain-predicted age', derived using structural neuroimaging. Brain-predicted age was calculated machine-learning analysis, trained neuroimaging data from large healthy...
Abstract Increasing evidence recognizes Alzheimer's disease (AD) as a multifactorial and heterogeneous with multiple contributors to its pathophysiology, including vascular dysfunction. The recently updated AD Research Framework put forth by the National Institute on Aging–Alzheimer's Association describes biomarker‐based pathologic definition of focused amyloid, tau, neuronal injury. In response this article, here we first discussed that dysfunction is an important early event in...
Quantifying the microstructural properties of human brain's connections is necessary for understanding normal ageing and disease. Here we examine brain white matter magnetic resonance imaging (MRI) data in 3,513 generally healthy people aged 44.64-77.12 years from UK Biobank. Using conventional water diffusion measures newer, rarely studied indices neurite orientation dispersion density imaging, document large age associations with microstructure. Mean diffusivity most age-sensitive measure,...
Two previous pan-European consensus meetings, the 1995 and 2006 Helsingborg were convened to review scientific evidence state of current services identify priorities for research development set targets stroke care decade follow. Adhering same format, European Stroke Organisation (ESO) prepared a Action Plan (ESAP) years 2018 2030, in cooperation with Alliance Europe (SAFE). The ESAP included seven domains: primary prevention, organisation services, management acute stroke, secondary...
The bedside clinical assessment of the patient with suspected stroke has not been well studied. Improving skills may accelerate progress through emergency department. We aimed to determine frequency and nature mimics identify key features that distinguish between mimic at bedside.Consecutive presentations an urban teaching hospital were recruited. A standard was performed. final diagnosis determined by expert panel, which had access features, brain imaging, other tests. Univariate...