A5031248234- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Venous Thromboembolism Diagnosis and Management
- Advanced MRI Techniques and Applications
- Intracerebral and Subarachnoid Hemorrhage Research
- Radiation Dose and Imaging
- Advanced X-ray and CT Imaging
- Stroke Rehabilitation and Recovery
- Intracranial Aneurysms: Treatment and Complications
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Medical Imaging Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Medical Imaging and Analysis
- Glioma Diagnosis and Treatment
- Neurosurgical Procedures and Complications
- Radiology practices and education
- Peripheral Artery Disease Management
- Meningioma and schwannoma management
- Cardiac Imaging and Diagnostics
- Emergency and Acute Care Studies
- Machine Learning in Healthcare
- Artificial Intelligence in Healthcare and Education
- Trauma and Emergency Care Studies
Massachusetts General Hospital
2016-2025
Harvard University
2016-2025
Boston University
2003-2025
MSB Medical School Berlin
2025
Brigham and Women's Hospital
2019-2025
University of Washington
2025
Athinoula A. Martinos Center for Biomedical Imaging
2009-2024
University of California, Irvine
2024
Pennsylvania State University
2024
University of Pennsylvania
2024
To evaluate acute stroke with conventional, multisection diffusion-weighted (DW), and hemodynamically weighted (HW) magnetic resonance (MR) imaging.The three MR imaging techniques were performed in 11 patients within 10 hours of the onset hemiparesis. The volume DW HW abnormalities compared infarct volumes depicted at initial and/or follow-up or computed tomography (CT).Findings abnormal nine patients, despite normal findings CT MR. In all infarcts abnormality was generally smaller larger...
Background and Purpose— Acute ischemic stroke due to large vessel occlusion (LVO)—vertebral, basilar, carotid terminus, middle anterior cerebral arteries—likely portends a worse prognosis than unassociated with LVO. Because little prospective angiographic data have been reported on cohort of unselected patients transient attack, the clinical impact LVO has difficult quantify. Methods— The Screening Technology Outcome Project in Stroke Study is imaging-based study outcomes performed at 2...
Background: Rapid and easy clinical assessments for volumes of infarction perfusion mismatch are needed. We tested whether simple geometric models generated accurate estimates these volumes.
Background and Purpose— Despite the abundance of emerging multimodal imaging techniques in field stroke, there is a paucity data demonstrating strong correlation between findings clinical outcome. This study explored how proximal arterial occlusions alter flow collateral vessels whether occlusion or extent collaterals correlates with prehospital symptoms fluctuation worsening since onset predict in-hospital worsening. Methods— Among 741 patients enrolled prospective cohort involving CT...
Background and Purpose— The role of noninvasive methods in the evaluation collateral circulation has yet to be defined. We hypothesized that a favorable pattern leptomeningeal collaterals, as identified by CT angiography, correlates with improved outcomes. Methods— Data from prospective cohort study at 2 university-based hospitals where angiography was systematically performed acute phase ischemic stroke were analyzed. Patients complete occlusion intracranial internal carotid artery and/or...
<b>Background: </b> A subset of patients with cerebral amyloid angiopathy (CAA) present cognitive symptoms, seizures, headaches, T2-hyperintense MRI lesions, and neuropathologic evidence CAA-associated vascular inflammation. <b>Objective: To analyze the risk factors, diagnostic characteristics, long-term course this disorder. <b>Methods: We assessed 14 consecutive pathologically diagnosed CAA-related inflammation, 12 available neuroimaging follow-up data. Patients were evaluated for...
<h3>BACKGROUND AND PURPOSE:</h3> Large admission DWI lesion volumes are associated with poor outcomes despite acute stroke treatment. The primary aims of our study were to determine whether CTA collaterals correlate in patients AIS proximal occlusions, and a collateral profile could identify large high specificity. <h3>MATERIALS METHODS:</h3> We studied 197 M1 and/or intracranial ICA occlusions. segmented follow-up volumes, categorized by using 5-point CS system. ROC analysis was used...
Background and Purpose— Patients with large vessel occlusion strokes (LVOS) may be better served by direct transfer to endovascular capable centers avoiding hazardous delays between primary comprehensive stroke centers. However, accurate field triage remains challenging. We aimed develop a simple scale identify LVOS. Methods— The Field Assessment Stroke Triage for Emergency Destination (FAST-ED) was based on items of the National Institutes Health Scale (NIHSS) higher predictive value LVOS...
Background and Purpose — The goal of this study was to evaluate the utility perfusion-weighted CT (PWCT) in predicting final infarct volume clinical outcome patients with acute middle cerebral artery (MCA) stroke. Methods Twenty-two consecutive MCA stem occlusion who underwent intra-arterial thrombolysis within 6 hours stroke onset had noncontrast angiography whole-brain PWCT imaging before treatment. Infarct volumes were computed from initial follow-up scans; measured modified Rankin scale....
<b>Background: </b> Patients with acute intracerebral hemorrhage (ICH) presenting within 3 hours of symptom onset are known to be at increased risk expansion. However, only a minority arrive this time frame. Therefore, alternative markers for expansion needed. <b>Objective: To examine whether contrast extravasation on CT angiography (CTA) presentation predicts subsequent hematoma <b>Methods: Consecutive patients primary ICH an urban tertiary care hospital were prospectively captured in...
Purpose The purpose of this work was to evaluate the accuracy CT angiography (CTA) for detection large vessel intracranial thrombus in clinically suspected hyperacute (<6 h) stroke patients. Method Forty-four consecutive intraarterial thrombolysis candidates underwent noncontrast followed immediately by CTA. Axial source and two-dimensional collapsed maximum intensity projection reformatted CTA images were rated presence or absence occlusion. Five hundred seventy-two circle-of-Willis vessels...
PURPOSE: To assess the use of nonstandard, variable window width and level review settings in computed tomography (CT) without contrast material administration detection acute stroke. MATERIALS AND METHODS: Nonenhanced CT was performed 21 patients with (<6 hours) middle cerebral arterial stroke nine control patients. Two blinded neuroradiologists rated all scans for presence parenchymal hypoattenuation. Images were reviewed at a picture archiving communication system (PACS) workstation,...
Lesion volume is often used as an end point in clinical trials of oncology therapy. We sought to compare the common method using orthogonal diameters estimate lesion (the diameter method) with a computer-assisted planimetric technique perimeter method).Radiologists reviewed 825 magnetic resonance imaging studies from 219 patients glioblastoma multiforme. Each study had independently estimated via and methods. Cystic areas were subtracted out or excluded outlined lesion. Inter- intrareader...
PURPOSE: To measure mean cerebral blood flow (CBF) in ischemic and nonischemic territories low-attenuation regions patients with acute stroke by using deconvolution-derived hemodynamic imaging. MATERIALS AND METHODS: Twelve middle artery 12 control were examined single-section computed tomography (CT) perfusion scanning. Analysis was performed a deconvolution-based algorithm. Comparisons of CBF, volume (CBV), transit time (MTT) determined between hemispheres all low- normal-attenuation...
Object. After conventional doses of 55 to 65 Gy fractionated irradiation, glioblastoma multiforme (GBM) usually recurs at its original location. This institutional phase II study was designed assess whether dose escalation 90 cobalt gray equivalent (CGE) with conformal protons and photons in accelerated fractionation would improve local tumor control patient survival. Methods. Twenty-three patients were enrolled this study. Eligibility criteria included age between 18 70 years, Karnofsky...
The recent "Advanced Neuroimaging for Acute Stroke Treatment" meeting on September 7 and 8, 2007 in Washington DC, brought together stroke neurologists, neuroradiologists, emergency physicians, neuroimaging research scientists, members of the National Institute Neurological Disorders (NINDS), Biomedical Imaging Bioengineering (NIBIB), industry representatives, US Food Drug Administration (FDA) to discuss role advanced acute treatment. goals were assess state-of-the-art practice terms imaging...
The presence of active contrast extravasation (the spot sign) on computed tomography (CT) angiography has been recognized as a predictor hematoma expansion in patients with intracerebral hemorrhage. We aim to systematically characterize the sign identify features that are most predictive and construct scoring system.