A5043946098- Epilepsy research and treatment
- Cardiac Arrest and Resuscitation
- Pharmacological Effects and Toxicity Studies
- Acute Ischemic Stroke Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Ethics in Clinical Research
- Trauma and Emergency Care Studies
- Traumatic Brain Injury Research
- Neuroscience and Neuropharmacology Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Biomedical Ethics and Regulation
- Ethics in medical practice
- Venous Thromboembolism Diagnosis and Management
- Neonatal and fetal brain pathology
- Thermal Regulation in Medicine
- Statistical Methods in Clinical Trials
- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Palliative Care and End-of-Life Issues
- Health Systems, Economic Evaluations, Quality of Life
- Neurosurgical Procedures and Complications
- Stroke Rehabilitation and Recovery
- Meta-analysis and systematic reviews
- Emergency and Acute Care Studies
- S100 Proteins and Annexins
University of Michigan
2016-2025
Medical University of South Carolina
2017-2023
Massachusetts General Hospital
2021-2023
Michigan United
2017-2023
Michigan Medicine
2002-2023
The Ohio State University Wexner Medical Center
2021
Columbia University
2021
Children's National
2021
University of Washington
2021
Columbia University Irving Medical Center
2021
Limited data are available to guide the choice of a target for systolic blood-pressure level when treating acute hypertensive response in patients with intracerebral hemorrhage.We randomly assigned eligible participants hemorrhage (volume, <60 cm(3)) and Glasgow Coma Scale (GCS) score 5 or more (on scale from 3 15, lower scores indicating worse condition) 110 139 mm Hg (intensive treatment) 140 179 (standard order test superiority intensive reduction blood pressure standard reduction;...
Early termination of prolonged seizures with intravenous administration benzodiazepines improves outcomes. For faster and more reliable administration, paramedics increasingly use an intramuscular route.This double-blind, randomized, noninferiority trial compared the efficacy midazolam that lorazepam for children adults in status epilepticus treated by paramedics. Subjects whose convulsions had persisted than 5 minutes who were still convulsing after arrived given study medication either...
Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Progesterone has been shown to improve neurologic outcome in multiple experimental models two early-phase trials involving patients with TBI.
The choice of drugs for patients with status epilepticus that is refractory to treatment benzodiazepines has not been thoroughly studied.In a randomized, blinded, adaptive trial, we compared the efficacy and safety three intravenous anticonvulsive agents - levetiracetam, fosphenytoin, valproate in children adults convulsive was unresponsive benzodiazepines. primary outcome absence clinically evident seizures improvement level consciousness by 60 minutes after start drug infusion, without...
BackgroundEarly administration of convalescent plasma obtained from blood donors who have recovered coronavirus disease 2019 (Covid-19) may prevent progression in acutely ill, high-risk patients with Covid-19.MethodsIn this randomized, multicenter, single-blind trial, we assigned were being treated an emergency department for Covid-19 symptoms to receive either one unit a high titer antibodies against severe acute respiratory syndrome 2 (SARS-CoV-2) or placebo. All the 50 years age older had...
The recent "Advanced Neuroimaging for Acute Stroke Treatment" meeting on September 7 and 8, 2007 in Washington DC, brought together stroke neurologists, neuroradiologists, emergency physicians, neuroimaging research scientists, members of the National Institute Neurological Disorders (NINDS), Biomedical Imaging Bioengineering (NIBIB), industry representatives, US Food Drug Administration (FDA) to discuss role advanced acute treatment. goals were assess state-of-the-art practice terms imaging...
Although informed consent is important in clinical research, questions persist regarding when it necessary, what requires, and how should be obtained. The standard view research ethics that the function of to respect individual autonomy. However, processes are multidimensional serve other ethical functions as well. These deserve particular attention barriers exist. We argue serves seven ethically conceptually distinct functions. first four pertain principally participants: (1) providing...
Summary Early treatment of prolonged seizures with benzodiazepines given intravenously by paramedics in the prehospital setting has been shown to be associated improved outcomes. However, an increasing number Emergency Medical System (EMS) protocols use intramuscular (IM) route because it is faster and consistently achievable. RAMPART (Rapid Anticonvulsant Medication Prior Arrival Trial) a double‐blind randomized clinical trial determine if efficacy IM midazolam noninferior margin 10% that...
In a previous study, 0.3 and 0.45 mg/kg of intravenous recombinant tissue plasminogen activator (rt-PA) were safe when combined with eptifibatide 75 mcg/kg bolus 2-hour infusion (0.75 per minute). The Combined Approach to Lysis Utilizing Eptifibatide rt-PA in Acute Ischemic Stroke-Enhanced Regimen (CLEAR-ER) trial sought determine the safety higher-dose regimen establish evidence for phase III trial.CLEAR-ER was multicenter, double-blind, randomized study. stroke patients 0.6 plus (135 at...
Abstract Objective This study was undertaken to describe patterns of benzodiazepine use as first‐line treatment status epilepticus (SE) and test the association doses with response second‐line agents in patients enrolled Established Status Epilepticus Treatment Trial (ESETT). Methods Patients refractory an adequate dose benzodiazepines for SE were ESETT. Choice benzodiazepine, given prior administration agent, route administration, setting, patient weight characterized. These compared...
Summary Benzodiazepine‐refractory status epilepticus (established epilepticus, ESE) is a relatively common emergency condition with several widely used treatments. There are no controlled, randomized, blinded clinical trials to compare the efficacy and tolerability of currently available treatments for ESE. The ESE treatment trial designed determine most effective and/or least among patients older than 2 years by comparing three arms: fosphenytoin ( fPHT ) levetiracetam (LVT), valproic acid...
Summary Objective To examine the effectiveness of intramuscular ( IM ) midazolam versus intravenous IV lorazepam for treatment pediatric patients with status epilepticus SE in prehospital care setting. Methods This multicenter clinical trial randomized diagnosed to receive either or administered by paramedics Included this secondary analysis were only younger than 18 years age. Evaluated associations group vs. primary outcome, defined as seizure cessation prior emergency department ED...
Background and Purpose— An increased risk of hemorrhagic transformation is a major factor limiting the use tissue plasminogen activator for stroke. Increased also found in animals undergoing transient focal cerebral ischemia with hyperglycemia; this study examined whether hyperbaric oxygen (HBO) could reduce such rat model. Methods— Rats received an injection 50% glucose (6 mL/kg intraperitoneally) had middle artery occlusion 10 minutes later. were treated HBO (3 ATA 1 hour) 30 after...
Summary Early treatment of prolonged seizures with benzodiazepines given intravenously by paramedics in the prehospital setting had been shown to be associated improved outcomes, but comparative efficacy and safety an intramuscular ( IM ) route, which is faster consistently achievable, was previously unknown. RAMPART (the R apid A nticonvulsant M edication P rior rrival T rial) a double‐blind randomized clinical trial determine if (IM) midazolam noninferior margin 10% that intravenous IV...