A5075454255- Anesthesia and Neurotoxicity Research
- Anesthesia and Sedative Agents
- Epilepsy research and treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
- Economic and Financial Impacts of Cancer
- Health Systems, Economic Evaluations, Quality of Life
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- EEG and Brain-Computer Interfaces
- COVID-19 and healthcare impacts
- Infant Development and Preterm Care
- Multiple and Secondary Primary Cancers
- Lung Cancer Diagnosis and Treatment
- Cerebral Palsy and Movement Disorders
- Colorectal Cancer Treatments and Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pleural and Pulmonary Diseases
- Telemedicine and Telehealth Implementation
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Pediatric Pain Management Techniques
- Cardiac electrophysiology and arrhythmias
- Neonatal and fetal brain pathology
- Delphi Technique in Research
Boston Children's Hospital
2020-2025
Harvard University
2021-2025
Brown University
2021-2023
Medical University of South Carolina
2020-2021
Harvard University Press
2021
Abstract Objective This study was undertaken to describe patterns of benzodiazepine use as first‐line treatment status epilepticus (SE) and test the association doses with response second‐line agents in patients enrolled Established Status Epilepticus Treatment Trial (ESETT). Methods Patients refractory an adequate dose benzodiazepines for SE were ESETT. Choice benzodiazepine, given prior administration agent, route administration, setting, patient weight characterized. These compared...
Importance Low-dose computed tomography (LDCT) lung screening has been shown to reduce cancer mortality. Significant incidental findings (SIFs) have widely reported in patients undergoing LDCT screening. However, the exact nature of these SIF not described. Objective To describe SIFs arm National Lung Screening Trial and classify as reportable or referring clinician (RC) using American College Radiology’s white papers on findings. Design, Setting, Participants This was a retrospective case...
Abstract Introduction While telemedicine usage has increased due to the COVID-19 pandemic, there remains little consensus about how spine surgeons perceive virtual care. The purpose of this study was explore international perspectives providers on challenges and benefits telemedicine. Methods Responses from 485 members AO Spine were analyzed, covering provider perceptions All questions optional, blank responses excluded analysis. Results leading reported by decreased ability perform physical...
It is unknown how often and early EEG obtained in patients presenting with status epilepticus. The Established Status Epilepticus Treatment Trial enrolled benzodiazepine-refractory seizures randomized participants to fosphenytoin, levetiracetam, or valproate. use of EEG, including frequency electrographic seizures, was determined participants.Secondary analysis 475 enrollments at 58 hospitals determine the performed within 24 hours presentation. type, prevalence characteristics associated...
Previous studies have raised concerns regarding neurodevelopmental impacts of early exposures to general anesthesia and surgery. Electroencephalography (EEG) can be used study ontogeny brain networks during infancy. As a substudy an ongoing study, we examined measures functional connectivity in awake infants with prior prolonged anesthetic control infants. EEG was assessed using debiased weighted phase lag index at source sensor levels graph theoretical for resting state activity the (n = 26...
Objective: To evaluate recovery from neuromuscular blockade in infants using Train-of-Four nerve stimulation. Study Design: Ulnar stimulation was used to evoke thumb twitch and reported as a ratio. Thumb also recorded visually real-time. The primary outcome time near of muscle function (Train-of-Four ratio >70%). Secondary analyses were greater degrees recovery, >80%, 90%), the sensitivity accelerometry versus visual thumb-twitch clinical variates assess safety. Results: Patients enrolled...
Background Tactile sensitivity in the infant period is poorly characterized, particularly among children with prior surgery, anaesthesia or critical illness. The study aims were to investigate tactile of foot and associated coordination lower limb motor movement typically developing infants without hospital experience, develop feasible bedside sensory testing protocols. Materials methods A prospective, longitudinal 69 at 2 4 months-old, admission. Mechanical stimuli applied graded innocuous...
Background Atrial fibrillation/flutter (AF) after transient ischemic attack (TIA) has not been well studied. We compared the likelihood of new AF diagnosis stroke versus TIA. Methods and Results The POINT (Platelet-Oriented Inhibition in New TIA Minor Ischemic Stroke) trial enrolled adults within 12 hours minor or high-risk Our exposure was index event type (ischemic TIA). primary analysis used original definition (resolution symptoms/signs). In secondary analyses, cases with infarction on...
6597 Background: We prospectively assessed financial burden (FB) due to treatment costs among patients with colorectal cancer (CRC) recruited by NCI Community Oncology Research Program (NCORP) sites. Methods: Patients newly diagnosed CRC treated curative intent enrolled through NCORP sites and completed the FACIT Comprehensive Score for Financial Toxicity (COST) instrument at 0-, 3, 6, 12 months. Higher COST score (range 0-44) indicates greater well-being. Effects of demographic, clinical,...
1518 Background: Cancer therapy costs continue to rise, resulting in FB. FB CRC treated with curative intent remains unexplored, particularly the community oncology setting. We assess baseline and 3-month change, including predictors. Methods: Patients newly diagnosed were enrolled through NCI Community Oncology Research Program (NCORP) Sites a longitudinal study completed validated FACIT Comprehensive Score for Financial Toxicity (COST) instrument at 3 months. Higher COST score (range 0-44)...