A5038914778- Botulinum Toxin and Related Neurological Disorders
- Multiple Sclerosis Research Studies
- Cerebral Palsy and Movement Disorders
- Stroke Rehabilitation and Recovery
- Peripheral Neuropathies and Disorders
- Long-Term Effects of COVID-19
- Ultrasound and Hyperthermia Applications
- Systemic Sclerosis and Related Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Hereditary Neurological Disorders
- Traumatic Brain Injury Research
- Diphtheria, Corynebacterium, and Tetanus
- Intensive Care Unit Cognitive Disorders
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Amyotrophic Lateral Sclerosis Research
- Spinal Cord Injury Research
- Viral Infections and Immunology Research
- Acute Ischemic Stroke Management
- RNA regulation and disease
- Neurological and metabolic disorders
- Cancer Treatment and Pharmacology
- Cardiac Arrest and Resuscitation
- Rheumatoid Arthritis Research and Therapies
National Hospital for Neurology and Neurosurgery
2016-2025
University College London
2016-2025
University College London Hospitals NHS Foundation Trust
2018-2025
University of Michigan
1995-2024
Michigan State University
2021
Corewell Health Blodgett Hospital
2021
Stanford University
2021
Spectrum Health
2021
Cooper University Hospital
2021
Royal London Hospital
2021
BackgroundEarly administration of convalescent plasma obtained from blood donors who have recovered coronavirus disease 2019 (Covid-19) may prevent progression in acutely ill, high-risk patients with Covid-19.MethodsIn this randomized, multicenter, single-blind trial, we assigned were being treated an emergency department for Covid-19 symptoms to receive either one unit a high titer antibodies against severe acute respiratory syndrome 2 (SARS-CoV-2) or placebo. All the 50 years age older had...
The unique clinical characteristics of primary progressive multiple sclerosis (PPMS) pose particular diagnostic difficulties, both in excluding other causes syndromes and confirming the diagnosis MS, which is not adequately addressed by current criteria. This article presents new criteria developed a group investigators on basis review their considerable experience with PPMS. (We conclude that at least 1 year progression must be documented before PPMS made.) Three levels certainty have been...
<b><i>Background:</i></b> Patients with primary progressive MS have atypical clinical and MRI characteristics been excluded from most therapeutic trials. The authors report a randomized, controlled trial restricted to MS. <b><i>Methods:</i></b> Fifty subjects were randomized weekly IM interferon β-1a 30 μg, 60 or placebo for 2 years. endpoint was time sustained progression in disability. Secondary outcomes included the timed 10-meter walk, nine-hole peg test, on MRI, T2 T1 brain lesion loads...
<b>Objective:</b> To assess whether it is possible to measure changes in cord-sectional area during a 1-year period patients with MS reliably. <b>Background:</b> Involvement of the spinal cord extremely common and an important element development disability. Although little relation shown between lesion load disability, strong correlation atrophy expanded disability status scale (EDSS) has been demonstrated cross-sectional studies. <b>Method:</b> A highly reproducible semiautomated technique...
<b><i>Background:</i></b> Ten percent of patients with MS have a progressive course from onset no history relapses or remissions. A smaller subgroup follow similar but single relapse at some point (transitional [TP] MS). To date these been excluded receiving licensed treatments for and most therapeutic trials. <b><i>Objective:</i></b> document the clinical MRI characteristics large cohort patients, including 158 primary (PP) 33 TPMS. Data small reference group 20 secondary (SP) are also...
<h3>OBJECTIVE</h3> To document clinical and magnetic resonance imaging (MRI) characteristics of a large cohort primary transitional progressive multiple sclerosis (PP TP MS) patients over one year. <h3>INTRODUCTION</h3> Patients with PP or MS have been shown to low brain T2 T1 lesion loads slow rates new formation minimal gadolinium enhancement, despite their accumulating disability. Serial evaluation these is needed elucidate the pathological processes responsible for disease progression...
There are few longitudinal studies of cognition in patients with multiple sclerosis, and the results these remain inconclusive. No serial neuropsychological data an exclusively primary progressive series available. Cross-sectional analyses have revealed significant correlations between magnetic resonance imaging (MRI) parameters sclerosis (PPMS). This study investigated cognitive MRI change 99 PPMS from five European centres for 2 years. They were assessed at 12 month intervals using Brief...
Abstract Background Cardiac arrest is a common and devastating emergency of both the heart brain. More than 380,000 patients suffer out-of-hospital cardiac annually in USA. Induced cooling comatose markedly improved neurological functional outcomes pivotal randomized clinical trials, but optimal duration therapeutic hypothermia has not yet been established. Methods This study multi-center randomized, response-adaptive, (dose) finding, comparative effectiveness trial with blinded outcome...
The authors sought to identify clinical and MRI predictors of outcome in primary progressive multiple sclerosis (PPMS). Clinical assessments were performed at baseline 2 5 years (clinical only). At baseline, disease duration, expanded disability status scale (EDSS) brain volume predicted outcome. Adding short-term change variables, EDSS, changes T2* lesion load cord area, number new lesions predictive. variables predict long-term PPMS.
People with Hereditary and Sporadic Spastic Parapresis (SP) walk a stiff legged gait characterised by lack of knee flexion. We investigated the relationship between lower limb strength stiffness flexion during swing phase while walking in 20 people SP 18 matched controls. Maximal isometric was measured using dynamometer. Passive spasticity assessed motor-driven slow (5°/s) fast (60°/s) stretches at ankle subject relaxed or preactivating muscle. Walking 3D motion analysis. Isometric muscle...
This study documents changes in clinical and magnetic resonance imaging (MRI) characteristics a large cohort of patients with primary transitional progressive multiple sclerosis (PP TPMS) over 2 years. Patients PPMS TPMS were recruited from six European centres underwent MRI examination at three time points: baseline, year one two. Of the 190 data available on 125 (66%, five centres) 113 (59%, four Significant increases seen T2 load T1 hypointensity, while brain cord volume decreased. In...
Motion sickness is associated with gastric slow wave disruption. Animal models of disturbances show dependence on neural and prostaglandin pathways. Roles these pathways in circular vection-evoked dysrhythmias nausea were tested. Eight volunteers histories motion underwent vection (60 degrees/s), during which (0 = none to 3 severe) electrogastrographic parameters assessed. Tachygastric activity was expressed as the signal percentage at frequencies > 4.5 cycles/min. Circular induced a...