A5102839409- Multiple Sclerosis Research Studies
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Bone and Joint Diseases
- Systemic Sclerosis and Related Diseases
- Polyomavirus and related diseases
- Ultrasound and Hyperthermia Applications
- Enhanced Recovery After Surgery
- Intensive Care Unit Cognitive Disorders
- Peripheral Neuropathies and Disorders
- Fetal and Pediatric Neurological Disorders
- Spinal Dysraphism and Malformations
- Respiratory Support and Mechanisms
- Gastric Cancer Management and Outcomes
- Prion Diseases and Protein Misfolding
- Long-Term Effects of COVID-19
- Rheumatoid Arthritis Research and Therapies
- Metabolomics and Mass Spectrometry Studies
- Systemic Lupus Erythematosus Research
- Medical Imaging Techniques and Applications
- Infectious Aortic and Vascular Conditions
- Non-Invasive Vital Sign Monitoring
- Forensic Entomology and Diptera Studies
- Ultrasound Imaging and Elastography
- Cancer survivorship and care
Agostino Gemelli University Polyclinic
2024
Istituti di Ricovero e Cura a Carattere Scientifico
2024
Cleveland Clinic
2023
Hamad Medical Corporation
2023
University of Verona
2011-2020
University of Cagliari
2019-2020
Ospedale per gli Infermi
2018
Ospedale degli Infermi
2018
Vita-Salute San Raffaele University
2004-2010
IRCCS Ospedale San Raffaele
2004-2009
Conventional MRI can reveal decreases in brain volumes with aging but fails to provide information about the underlying microstructural modifications. Magnetization transfer (MT) and diffusion tensor (DT) part overcome these limitations.To investigate influence of on conventional MT DT MRI-derived measurements white (WM) gray (GM) matter.Dual-echo, T1-weighted, MR images were obtained 89 healthy subjects (age range 11 76 years). Normalized GM WM measured ratio (MTR) mean diffusivity (MD)...
<h3>Background</h3> Diffusion-tensor (DT) magnetic resonance imaging (MRI) has the potential to elucidate some characteristics of tissue microstructure inaccessible other MRI techniques. <h3>Objective</h3> To investigate whether normal-appearing brain abnormalities occur in patients with multiple sclerosis at earliest clinical stage and their severity is predictive a short-term disease evolution by using DT MRI. <h3>Design</h3> Forty-five 22 healthy control subjects were studied. All had...
<b>Objective:</b> To investigate the extent and severity of cervical cord damage using diffusion tensor MRI (DT-MRI) histogram analysis in patients with primary progressive MS (PPMS). <b>Methods:</b> Diffusion-weighted sensitivity-encoded (SENSE) echoplanar images brain dual-echo diffusion-weighted scans were acquired from 24 PPMS 13 healthy controls. Cord mean diffusivity fractional anisotropy histograms produced. An variance model, adjusting for volume, was used to compare DT-MRI...
<b>Background:</b> Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with severe cervical cord damage due to degeneration of the corticospinal tracts and loss lower motor neurones. Diffusion tensor magnetic resonance imaging (DT MRI) allows measurement quantities reflecting size (such as mean diffusivity) orientation fractional anisotropy) water-filled spaces in biological tissues. <b>Methods:</b> Mean diffusivity anisotropy histograms from patients ALS were obtained to: (1)...
<h3>Background</h3> Moderate-to-severe cancer-related fatigue occurs in 45% of patients with cancer and interferes many aspects quality life. Although physical exercise has level 1 evidence for improvement fatigue, it a relatively high behavioural demand compared other non-pharmacological interventions. The aim this updated meta-analysis was to address the efficacy light therapy improving cancer. <h3>Methods</h3> We included randomised controlled trials investigating bright white (BWL)...
Although the mechanisms underlying accumulation of disability in primary progressive (PP) multiple sclerosis (MS) are still unclear, a major role seems to be played by `occult' tissue damage. We investigated whether conventional and magnetization transfer (MT) MRI may provide complementary information for assessment PPMS severity. Conventional MT scans from 226 patients 84 healthy controls were collected centralized analysis. The expanded status scale (EDSS) score was rated at time...
The authors sought to identify clinical and MRI predictors of outcome in primary progressive multiple sclerosis (PPMS). Clinical assessments were performed at baseline 2 5 years (clinical only). At baseline, disease duration, expanded disability status scale (EDSS) brain volume predicted outcome. Adding short-term change variables, EDSS, changes T2* lesion load cord area, number new lesions predictive. variables predict long-term PPMS.
To define the nature and temporal evolution of neuronal/axonal injury in patients at earliest clinical stage multiple sclerosis (MS), using whole brain N-acetylaspartate (WBNAA) proton MR spectroscopy (1H-MRS).Thirty-five presentation with clinically isolated syndromes (CIS) MRI evidence disease dissemination space were studied. The following scans acquired within 3 months from onset after 12 months: 1) dual-echo; 2) WBNAA 1H-MRS; 3) pre- postcontrast T1-weighted. same obtained age-matched...
The authors assessed the ability of diffusion tensor MRI to grade cervical cord damage in 10 patients with neuromyelitis optica, multiple sclerosis, and healthy controls. three groups differed terms average mean diffusivity (<i>p</i> = 0.008) fractional anisotropy 0.04). There was a correlation between Expanded Standard Disability Status Scale score (<i>r</i> 0.52, <i>p</i> 0.02).
<h3>Background:</h3> Diffusion tensor (DT) MRI enables quantification of the severity brain and cervical cord pathology in multiple sclerosis (MS). <h3>Objective:</h3> To investigate DT patterns damage patients with benign MS (BMS) secondary progressive (SPMS), order to achieve a better understanding mechanisms underlying development irreversible disability MS. <h3>Methods:</h3> Conventional scans were acquired from 40 BMS patients, 28 SPMS 18 healthy individuals. Cervical mean diffusivity...
Cervical cord magnetization transfer ratio (MTR) histograms were obtained from 45 patients at presentation with clinically isolated syndromes (CIS) suggestive of multiple sclerosis (MS). The mean values MTR histogram-derived metrics not different between CIS and healthy control subjects or without evidence disease dissemination in time. Only three showed significantly lower than subjects. These findings suggest the absence intrinsic structural damage cervical soon after onset MS, even those...
Background: There is an increasing body of evidence that magnetic resonance imaging-occult tissue damage important component primary progressive multiple sclerosis (PPMS) pathology.Proton spectroscopy ( 1 H-MRS) can be used to measure in vivo wholebrain N-acetylaspartate (WBNAA) concentrations, the decrease whose levels considered a marker neuronalaxonal injury.Objectives: To study WBNAA H-MRS as tool provide information about irreversible brain PPMS and investigate relationship between...
Objective The term benign multiple sclerosis (BMS) is referred to patients who have a mild or absent disability several years after disease clinical onset. Axonal damage can be measured in vivo using proton MR spectroscopy ( 1 H-MRS). In this study, we quantified the severity of “global” axonal BMS and early relapsing–remitting (RR) MS patients, whole brain N-acetylaspartate (WBNAA) H-MRS, better elucidate structural correlates non-disabling evolution. Methods WBNAA concentration was 37 with...
<h3>BACKGROUND AND PURPOSE:</h3> Neuro-axonal damage is a well known sequelae of MS pathogeneses. Consequently, our aim was to test whether the ∼20% patients with exhibiting clinically benign disease course also have minimal neural dysfunction as reflected by global concentration their MR imaging marker NAA. <h3>MATERIALS METHODS:</h3> <i>Q</i><i><sub>NAA</sub></i> obtained nonlocalizing whole-head <sup>1</sup>H-MR spectroscopy in 43 RRMS (30 women, 13 men; mean age, 44.7 ± 7.3 years age)...
Inconvenient administration and side effects of some disease-modifying therapies (DMTs) for relapsing multiple sclerosis (RMS) can deter adherence. We evaluated treatment satisfaction with cladribine tablets (CladT) RMS in the Arabian Gulf. This was a non-interventional, multicentre, prospective observational study non-pregnant/lactating adults (aged ≥ 18 years) eligible 1st CladT (EU labelling). The primary outcome overall at 6 months (Treatment Satisfaction Questionnaire Medication...
<b>SUMMARY:</b> Although the concentration of <i>N</i>-acetylaspartate (NAA) is often used as a neuronal integrity marker, its normal temporal variations are not well documented. To assess them over 1–2 year periods typical clinical trials, whole-brain NAA was measured longitudinally, 4 years, in cohort healthy young adults. No significant change (adjusted for both sex and age) either interpersonally or intrapersonally entire duration study.
Whereas focal and diffuse brain damage on conventional MRI is seen in patients with neuropsychiatric systemic lupus erythematosus (NSLE), the spinal cord seems to be rarely involved. Diffusion tensor (DT) provides information patterns of tissue disruption central nervous system, which may go undetected by MRI.To quantify extent otherwise "occult" injury cervical NSLE, improve our understanding its nature.Conventional DT scans were acquired from 11 NSLE 10 healthy controls. Histograms mean...