A5024199819- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Systemic Lupus Erythematosus Research
- RNA regulation and disease
- Mitochondrial Function and Pathology
- Cerebrovascular and genetic disorders
- Functional Brain Connectivity Studies
- Rheumatoid Arthritis Research and Therapies
- Polyomavirus and related diseases
- Ultrasound and Hyperthermia Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Ultrasound Imaging and Elastography
- Viral Infections and Immunology Research
- Genetic Neurodegenerative Diseases
- Alzheimer's disease research and treatments
- Neurogenesis and neuroplasticity mechanisms
- Metabolism and Genetic Disorders
- Metalloenzymes and iron-sulfur proteins
- Moyamoya disease diagnosis and treatment
- Long-Term Effects of COVID-19
- Traumatic Brain Injury and Neurovascular Disturbances
- Systemic Sclerosis and Related Diseases
- Herpesvirus Infections and Treatments
University of Siena
2016-2025
Center for Neurosciences
2023-2025
University College London
2007-2024
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2024
University of Turin
1998-2024
Azienda Ospedaliera Universitaria Senese
2007-2024
National Hospital for Neurology and Neurosurgery
2010-2024
National Institute for Health Research
2024
John Wiley & Sons (United States)
2024
Hudson Institute
2024
<h3>Objective</h3> To assess axonal damage and its contribution to disability at different stages of multiple sclerosis (MS). <h3>Background</h3> Recent in vivo imaging situ pathologic studies have demonstrated that substantial accompanies the inflammatory lesions MS. However, relation duration MS disease remain poorly defined. <h3>Design</h3> We performed proton magnetic resonance spectroscopic 88 patients with a wide range clinical measure<i>N</i>-acetylaspartate (NAA, an index integrity)...
It has been difficult to establish a strong correlation between total brain T2-weighted lesion volume on MRI and clinical disability in multiple sclerosis, part because of the lack pathological specificity signal changes. Proton magnetic resonance spectroscopy studies have shown that measurements intensity N-acetylaspartate (which is localized exclusively neurons neuronal processes mature brain) can provide specific index axonal damage or dysfunction. Here we report 30-month longitudinal...
Normal ageing is associated with gradual brain atrophy. Determining spatial and temporal patterns of change can help shed light on underlying mechanisms. Neuroimaging provides various measures structure that be used to assess such age-related but studies date have typically considered single imaging measures. Although there consensus the notion deteriorates age, evidence precise time course distribution changes mixed. We assessed grey matter (GM) white (WM) in a group 66 adults aged between...
Purpose Quantitative measurement of change in brain size and shape (e.g., to estimate atrophy) is an important current area research. New methods analysis attempt improve robustness, accuracy, extent automation. A fully automated method has been developed that achieves high estimation accuracy. Method longitudinal presented here, which automatically segments from nonbrain each image, registers the two images while using estimated skull constrain scaling skew, finally estimates surface motion...
To assess cortical gray matter (GM) changes in MS and establish their relevance to clinical disability inflammatory of white (WM) patients with the relapsing-remitting (RR) primary progressive (PP) forms disease.Conventional MRI examinations were obtained definite who had either RR or PP form disease. An automated analysis tool was used conventional T1-weighted MR images obtain total brain volumes normalized for head size. Total lesion load estimated on proton density T2-weighted images. The...
Abstract N ‐Acetylaspartate (NAA), which constitutes the major proportion of dominant resonance in proton MR spectra brain, is localized mature brain exclusively neurons and neuronal processes. A decrease NAA has been observed many cerebral pathologies usually interpreted as an index irreversible loss. The authors report a follow‐up study six patients with acute damage (four from demyelinating lesion two mitochondrial encephalopathy lactic acidosis stroke‐like episodes [MELAS]). All...
Objective Gray matter (GM) atrophy occurs in all multiple sclerosis (MS) phenotypes. We investigated whether there is a spatiotemporal pattern of GM that associated with faster disability accumulation MS. Methods analyzed 3,604 brain high‐resolution T1‐weighted magnetic resonance imaging scans from 1,417 participants: 1,214 MS patients (253 clinically isolated syndrome [CIS], 708 relapsing‐remitting [RRMS], 128 secondary‐progressive [SPMS], and 125 primary‐progressive [PPMS]), over an...
See Stankoff and Louapre (doi:10.1093/brain/awy114) for a scientific commentary on this article. Grey matter atrophy is present from the earliest stages of multiple sclerosis, but its temporal ordering poorly understood. We aimed to determine sequence in which grey regions become atrophic sclerosis association with disability accumulation. In longitudinal study, we included 1417 subjects: 253 clinically isolated syndrome, 708 relapsing-remitting 128 secondary-progressive 125...
To assess the time course of brain atrophy and difference across clinical subtypes in multiple sclerosis (MS).The percent volume change (PBVC) was computed on existing longitudinal (2 points) T1-weighted MRI from untreated (trial nontrial) patients with MS. Patients (n = 963) were classified as clinically isolated syndromes suggestive MS (CIS, 16%), relapsing-remitting (RR, 60%), secondary progressive (SP, 15%), primary (9%) The median length follow-up 14 months (range 12-68).There marked...
Background: A significant inflammatory pathologic disorder in the cortex of patients with multiple sclerosis (MS) has been demonstrated by ex vivo studies.Objective: To determine frequency, time appearance, and clinical relevance intracortical lesions (ICLs) MS vivo.Design: Double inversion recovery sequence study.Setting: Multiple Sclerosis Centre Veneto Region.Patients: We enrolled 380 (116 clinically isolated syndrome [CIS], 163 relapsingremitting [RRMS], 101 secondary progressive [SPMS])...
<h3>Objective</h3> To determine whether brain atrophy and lesion volumes predict subsequent 10 year clinical evolution in multiple sclerosis (MS). <h3>Design</h3> From eight MAGNIMS (MAGNetic resonance Imaging MS) centres, we retrospectively included 261 MS patients with MR imaging at baseline after 1–2 years, Expanded Disability Status Scale (EDSS) scoring years. Annualised whole atrophy, central rates T2 were calculated. Patients categorised by diagnosis as primary progressive (n=77),...
Abstract MR‐based measurements of brain volumes may be affected by the presence white matter (WM) lesions. Here, we assessed how and to what extent this happen for WM lesions various sizes intensities. After inserting different intensities into T1‐W images healthy subjects, effect on two widely used automatic methods volume measurement such as SIENAX (segmentation‐based) SIENA (registration‐based). To explore relevance partial (PV) estimation, performed experiments with PV models,...
To report the 5-year risk and to identify factors for development of a seminal acute or progressive clinical event in multi-national cohort asymptomatic subjects meeting 2009 RIS Criteria.Retrospectively identified from 22 databases within 5 countries were evaluated. Time first related demyelination (acute 12-month progression neurological deficits) was compared across different groups by univariate multivariate analyses utilizing Cox regression model.Data available 451 (F: 354 (78.5%)). The...