A5005439850- Multiple Sclerosis Research Studies
- Advanced Neuroimaging Techniques and Applications
- Immunotherapy and Immune Responses
- Polyomavirus and related diseases
- T-cell and B-cell Immunology
- Peripheral Neuropathies and Disorders
- Amyotrophic Lateral Sclerosis Research
- Systemic Sclerosis and Related Diseases
- Viral Infections and Immunology Research
- Herpesvirus Infections and Treatments
- Monoclonal and Polyclonal Antibodies Research
- T-cell and Retrovirus Studies
- Advanced MRI Techniques and Applications
- Virology and Viral Diseases
- Vestibular and auditory disorders
- Cerebral Palsy and Movement Disorders
- Bone and Joint Diseases
- Plant Virus Research Studies
- Reproductive System and Pregnancy
- RNA regulation and disease
- Neurogenesis and neuroplasticity mechanisms
- Immune Response and Inflammation
- Ophthalmology and Eye Disorders
- Chromosomal and Genetic Variations
- Complement system in diseases
Sapienza University of Rome
2015-2024
Istituto Nazionale di Fisica Nucleare, Sezione di Roma I
2024
Don Carlo Gnocchi Foundation
2014-2024
Istituti di Ricovero e Cura a Carattere Scientifico
1995-2018
Universidade do Estado do Rio de Janeiro
2018
National Centre for Disease Prevention and Control
2013
Institute of Biostructure and Bioimaging
2013
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2013
International Flame Research Foundation
2012
Politecnico di Milano
2011
<h3>Background</h3> Diffusion-tensor magnetic resonance imaging is sensitive to the more destructive aspects of multiple sclerosis (MS) evolution occurring outside and within T2-visible lesions and, as a consequence, holds promise for providing complete picture primary progressive (PP) MS–related tissue damage than conventional imaging. <h3>Objective</h3> To improve our understanding PPMS by assessing extent occult pathological features in normal-appearing white gray matter brain using...
The envelope protein from multiple sclerosis (MS) associated retroviral element (MSRV), a member of the Human Endogenous Retroviral family 'W' (HERV-W), induces dysimmunity and inflammation.The objective this study was to confirm specify association between HERV-W/MSRV (Env) expression MS.103 MS, 199 healthy controls (HC) with other neurological diseases (28), chronic infections (30) or autoimmunity were analysed an immunoassay detecting Env in serum. RNA DNA copy numbers peripheral blood...
Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the progressive and simultaneous degeneration of upper lower motor neurons. The pathological process associated to ALS, albeit more pronounced in motor/premotor cortices along corticospinal tracts (CST), does not spare extra‐motor brain gray (GM) white (WM) matter structures. However, it remains unclear whether such cerebral abnormalities occur with mildly disabling disease, how irreversible tissue...
<h3>BACKGROUND AND PURPOSE:</h3> Most DTI studies in ALS have been limited to the assessment of CST damage. In this study, we used tractography investigate whether microstructural abnormalities occur major motor and extramotor WM tracts mildly disabled patients with ALS. <h3>MATERIALS METHODS:</h3> Brain conventional MR imaging were performed 24 probable or definite mild disability (ALSFRS score, ≥20) 20 healthy controls. The mean disease progression rate was 0.62 (range = 0.08–2.50)....
Pathogenesis of autoimmune disorders, including Multiple Sclerosis (MS), has been linked to an alteration the resident microbial commensal community and interplay between microbiota immune system. Dietary components such as fibers, acting on composition, could, in principle, result modulation and, thus, could be used obtain beneficial outcomes for patients. We verified this hypothesis a pilot study involving two groups clinically similar Relapsing-Remitting (RR) MS patients who had undergone...
To evaluate Bacille Calmette-Guérin (BCG) effects after clinically isolated syndromes (CIS).In a double-blind, placebo-controlled trial, participants were randomly assigned to receive BCG or placebo and monitored monthly with brain MRI (6 scans). Both groups then entered preplanned phase IM interferon-β-1a for 12 months. From month 18 onward, the patients took disease-modifying therapies (DMTs) that their neurologist considered indicated in an open-label extension lasting up 60 months.Of 82...
<h3>Objective:</h3> In this multicenter study, a new semiautomatic method for segmenting the cervical cord from C2 to C5 was used investigate correlation between atrophy and clinical disability in large sample of patients with multiple sclerosis (MS). <h3>Methods:</h3> T2 3-dimensional T1-weighted scans dual-echo brain were acquired 143 healthy controls, 22 clinically isolated syndromes (CIS), 101 relapsing-remitting MS (RRMS), 79 secondary progressive (SPMS), 58 benign (BMS), 75 primary...
Approximately 15% of multiple sclerosis (MS) patients develop a progressive form disease from onset; this condition (primary progressive-PP) MS is difficult to diagnose and treat, associated with poor prognosis. Extracellular vesicles (EVs) brain origin isolated blood their protein cargoes could function as biomarker pathological conditions. We verified whether MBP MOG content in oligodendrocytes-derived EVs (ODEVs) be biomarkers help the differential diagnosis clinical phenotypes. A total...
In patients with primary progressive (PP) multiple sclerosis, brain MRI lesion activity and burden are low, despite the presence of severe neurological impairment. On contrary, degree cord atrophy diffuse tissue damage in cervical have been found to be associated clinical disability. Against this background, study aimed at providing an vivoindirect assessment pathology a large cohort PP sclerosis patients, using conventional magnetization transfer imaging (MTI). Ninety-one 36 secondary (SP)...
<b><i>Background:</i></b> Previous work has suggested that functional reorganization of cortical motor areas might have a role in limiting the deficits patients with MS. <b><i>Objective:</i></b> To test whether movement-associated changes MS extend beyond "classic" and involve sites for multimodal integration. <b><i>Methods:</i></b> fMRI was used to assess patterns brain activations associated 3 different tasks 30 right-handed primary progressive (PPMS) variable degrees impairment, which...
<h3>Objective:</h3> To define the temporal evolution of intrinsic tissue damage and atrophy in cervical cord brain portion corticospinal tracts (CST) from patients with amyotrophic lateral sclerosis (ALS). <h3>Methods:</h3> Conventional diffusion tensor (DT) magnetic resonance imaging (MRI) were obtained 17 ALS 20 controls, at baseline after a mean follow-up 9 months. The following measurements assessed: (a) cross-sectional area, average diffusivity (MD) fractional anisotropy (FA); (b) CST...
Abstract Corpus callosum (CC), the largest compact white matter fiber bundle of human brain involved in interhemispheric transfer, is frequently damaged course multiple sclerosis (MS). Cognitive impairment one factors affecting quality life patients with benign MS (BMS). The aim this study was to investigate relationship between cognitive profile BMS and extent tissue damage CC. Brain conventional DT MRI scans were acquired from 54 21 healthy controls. Neuropsychological tests (NPT)...
Background Interferon gamma (IFN-γ) production induces the transcription of indoleamine 2,3 dioxygenase (IDO) resulting in reduction T-cell activation and proliferation through depletion tryptophan elicitation Treg lymphocytes. IDO was shown to be involved pathogenesis autoimmune diseases; we investigated whether changes gene expression activity could indicative onset relapse multiple sclerosis (MS) patients. Methods interferon-γ expression, serum (Kynurenine/Tryptophan ratio) neopterin...
Background: Diffusion tensor magnetic resonance imaging (DT MRI) has the potential to provide in vivo information about tissue microstructure.In multiple sclerosis (MS), DT MRI disclosed presence of occult structural damage normal-appearing brain tissues.Objective: To investigate whether is sensitive longitudinal changes that may occur beyond resolution T2-weighted images patients with relapsing-remitting MS.Design: Twenty-six untreated relapsingremitting MS were followed up for 18...
<b>Objective: </b> Although in benign multiple sclerosis (BMS) locomotor disability is absent or only minimal, subclinical cognitive impairment seems to occur many cases. Diffusion tensor (DT) MRI enables us quantify the extent of "actual" tissue damage, which goes undetected when using conventional MRI. Against this background, we investigated structural brain damage underlying dysfunction BMS, with ultimate aim move a first step toward more reliable definition disease phenotype....
T lymphocytes costimulatory molecules, including CD80, CD86, CD28, CTLA4, PD-1, PD-L1, and B7-H3, are associated with the preferential production of pro- or anti-inflammatory cytokines. We analyzed expression these molecules myelin basic protein (MBP)-specific IL-10 IFN-gamma in patients multiple sclerosis (MS) relapsing-remitting acute (AMS, n = 40) stable (SMS, 38). Twenty-two successfully undergoing therapy glatimer acetate (n 12) IFNbeta 10) were also analyzed. MBP-specific...
To apply voxelwise analysis of diffusion-tensor (DT) magnetic resonance (MR) tractography and T2-weighted MR lesion measurements to characterize intrinsic damage the brain white matter (WM) tracts relation this presence location focal lesions among main clinical phenotypes multiple sclerosis (MS).The study was conducted with institutional review board approval. Written informed consent obtained from each participant. Brain dual-echo DT images were in 172 patients MS (22 [13%] clinically...
To assess the effect on diffusion tensor (DT) magnetic resonance imaging (MRI) of acquiring data with different scanners.Forty-four healthy controls and 36 multiple sclerosis patients low disability were studied using eight MR scanners acquisition protocols that as close to a standard protocol possible. Between 7 13 subjects in each center. Region-of-interest (ROI) histogram-based analyses fractional anisotropy (FA), axial (D(ax)), radial (D(rad)), mean diffusivity (MD) performed. The...