A5083411738- Alzheimer's disease research and treatments
- Tryptophan and brain disorders
- Multiple Sclerosis Research Studies
- MicroRNA in disease regulation
- Herpesvirus Infections and Treatments
- Polyomavirus and related diseases
- Viral-associated cancers and disorders
- Renal cell carcinoma treatment
- Pediatric health and respiratory diseases
- RNA regulation and disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Nutrition and Health in Aging
- Systemic Lupus Erythematosus Research
- Viral Infections and Immunology Research
- Cytomegalovirus and herpesvirus research
- Immune Cell Function and Interaction
- Prostate Cancer Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Asthma and respiratory diseases
- Parvovirus B19 Infection Studies
- GDF15 and Related Biomarkers
- MRI in cancer diagnosis
- Muscle Physiology and Disorders
- T-cell and B-cell Immunology
- Inflammasome and immune disorders
Don Carlo Gnocchi Foundation
2016-2025
Azienda Ospedaliero-Universitaria Careggi
2005-2024
University of Florence
2022-2023
University of Milan
2011-2013
Azienda Sanitaria di Firenze
1997
Prostate cancer (PCa) is the most frequent male malignancy and assessment of PCa aggressiveness, for which a biopsy required, fundamental patient management. Currently, multiparametric (mp) MRI strongly recommended before biopsy. Quantitative mpMRI might provide radiologist with an objective noninvasive tool supporting decision-making in clinical practice decreasing intra- inter-reader variability. In this view, high dimensional radiomics features Machine Learning (ML) techniques, along Deep...
Background Interferon gamma (IFN-γ) production induces the transcription of indoleamine 2,3 dioxygenase (IDO) resulting in reduction T-cell activation and proliferation through depletion tryptophan elicitation Treg lymphocytes. IDO was shown to be involved pathogenesis autoimmune diseases; we investigated whether changes gene expression activity could indicative onset relapse multiple sclerosis (MS) patients. Methods interferon-γ expression, serum (Kynurenine/Tryptophan ratio) neopterin...
The etiology of Parkinson’s disease (PD) is poorly understood, and strongly suspected to include both genetic environmental factors. In this context, it essential investigate possible biomarkers for prognostic diagnostic purposes. Several studies reported dysregulated microRNA expression in neurodegenerative disorders, including PD. Using ddPCR, we investigated the concentrations miR-7-1-5p, miR-499-3p, miR-223-3p miR-223-5p—miRNAs involved α-synuclein pathway inflammation—in serum...
Alzheimer's Disease is the most common form of dementia; its key pathological findings include deposition extracellular-neurotoxic-plaques composed amyloid-beta (Ab). AD-pathogenesis involves mechanisms that operate outside brain, and new researches indicate peripheral inflammation an early event in disease. Herein, we focus on a receptor known as triggering-receptor-expressed-on-myeloid-cells2 (TREM2), which promotes optimal immune cells function required to attenuate AD-progression is,...
Chronic obstructive pulmonary disease (COPD) is a disorder characterized by an abnormal inflammatory response that persists even after smoking cessation, yet the underlying mechanisms are not fully understood.To investigate expression of B-cell activating factor tumor necrosis family (BAFF), crucial mediator in crosstalk between innate and adaptive immune responses, patients with COPD to explore its correlation severity.Using immunohistochemistry, BAFF was examined lung specimens from 21...
Retrospective studies show that natalizumab modifies oligoclonal immunoglobulin (IgG) bands (OCBs) in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients. In this study, we prospectively analyzed both serum and CSF samples from 24 MS patients, before after 2 years natalizumab-based therapy. Our results showed complete (55%) or partial (27%) disappearance OCBs were taken Intrathecal IgG production, represented by index Loc , was also quantitatively reduced. data substantially...
Abstract Nitazoxanide (Alinia ® , NTZ) and tizoxanide (TIZ), its active circulating metabolite, belong to a class of agents known as thiazolides (TZD) endowed with broad anti-infective activities. TIZ RM-4848, the metabolite RM-5038, were shown stimulate innate immunity in vitro . Because natural resistance HIV-1 infection HIV-exposed seronegative (HESN) individuals is suggested be associated strong immune responses, we verified whether RM-4848 could reduce infectiousness HIV-1. Peripheral...
The etiopathology of multiple sclerosis (MS) is believed to include genetic and environmental factors. Human leukocyte antigen (HLA) alleles, in particular, are associated with disease susceptibility, whereas Epstein Barr Virus (EBV) infection has long been suspected play a role pathogenesis. aim the present study evaluate correlations between HLA alleles EBV MS. viral load (VL) serum anti-EBV antibody titers were evaluated EBV-seropositive MS patients (N = 117) age- sex-matched healthy...
Abstract MiR-223-3p is involved in the regulation of a broad range cellular processes and many types pathological as cancer, autoimmune inflammatory diseases. has been indicated negative regulator NLRP3 protein, key protein inflammasome. The chronic inflammasome activation, an underlying feature neurodegenerative disorders, induced by misfolded aggregates, including amyloid-beta alpha-synuclein, resulting pro-inflammatory cytokines secretion propagating neuroinflammation. aim study was to...
Demyelination and failure of remyelination are core mechanisms in the pathogenesis multiple sclerosis (MS); factor(s) modulating these processes still mostly unknown. MicroRNA 572 (miR-572) is deregulated MS suggested to targets neural cell adhesion molecule (NCAM), a glycoprotein involved CNS reparative mechanisms. The aim this study analyze miR-572 patients with different clinical phenotypes MS.qPCR quantification isolated from serum was performed 16 primary progressive (PP), 15 secondary...
Alzheimer's disease (AD) is a multifactorial with still barely understood etiology. Herpes simplex virus 1 (HSV-1) has long been suspected to play role in the pathogenesis of AD because its neurotropism, high rate infection general population, and life-long persistence neuronal cells, particularly same brain regions that are usually altered AD. The goal this study was evaluate HSV-1-specific humoral immune responses patients diagnosis either or amnestic mild cognitive impairment (aMCI),...
It has been widely demonstrated that siblings of children with autism spectrum disorder (ASD) have an increased risk abnormal developmental trajectories. In response to this, early recognition protocols developed worldwide, aiming promote interventions can positively impact the neurodevelopment this population. This paper presents protocol a controlled trial: ERI-SIBS (Early Recognition and Intervention in SIBlingS at High Risk for Neurodevelopment Disorders) is innovative ecological...
Abstract B lymphocytes contribute to the pathogenesis of Multiple Sclerosis (MS) by secreting antibodies and producing cytokines. This latter function was analyzed in myelin olygodendrocyte protein (MOG)-stimulated CD19+ 71 MS patients with different disease phenotypes 40 age-and sex-matched healthy controls (HC). Results showed that: 1) CD19+/TNFα+, CD19+/IL-12+ CD19+/IFNγ+ are significantly increased primary progressive (PP) compared secondary (SP), relapsing-remitting (RR), benign (BE)...
Background: Alzheimer’s disease (AD), the most common form of dementia worldwide, is associated with impairment in mechanisms clearing amyloid-β within a scenario neuroinflammation. The etiopathogenesis AD unclear, but role for viral infection suspected to play initiating disease. We recently described positive correlation between high titers HSV-1-specific antibodies (Ab) and volumes brain regions typically affected Objective: exploration possible Herpesviridae was extended by analyzing...
Herpes simplex virus type 1 (HSV-1) has long been suspected to play a role in Alzheimer's disease (AD), the most common form of dementia. IFN-lambda (IFN-λ) is one key cytokine innate antiviral defenses and, particular, an appreciable activity against HSV-1 infection. IFN -λ expression regulated by interaction between two different proteins: Mediator Complex 23 (MED23) and Interferon-Responsive Transcription Factor 7 (IRF7); single nucleotide polymorphisms (SNPs) these genes as well IFNL3...
Abstract Background Frailty, defined as physical performance impairment, is a common condition in older adults and can anticipate the development of sarcopenia, geriatric syndrome characterized by loss muscle strength mass. microRNAs (miRNAs) are short molecules RNA endowed with ability to modulate gene expression; miRNAs present serum considered potential biomarkers for several diseases. Serum concentration miR-451a, miR-93-5p, miR-155-5p, miR-421-3p, miR-425-5p, miR-495-3p miR-744-5p was...
Recent studies performing fiberoptic bronchoscopy in children have improved our understanding of asthma pathophysiology. Eosinophilic, but also neutrophilic, inflammation has been described asthma, the relationship with atopy was incompletely investigated. The aim this study is to examine inflammatory cells and mediators compared appropriate controls, i.e. atopic without no or asthma. Moreover, asthmatic were analysed separately based on presence stratified by age.We recruited 191 undergoing...
Abstract Background Classic Kaposi's Sarcoma (cKS) is a rare vascular tumor associated with Human Herpesvirus 8 (KSHV) infection, nevertheless not all KSHV-infected individuals have cKS. Objective We investigated whether particular KIR/HLA receptor/ligand genotypes would be preferentially present in and uninfected who or developed Methods were analyzed by molecular genotyping 50 did cKS 33 age-and sex-matched KSHV seronegative individuals. Results There was no association of individual KIR,...