A5020372887- Immune Cell Function and Interaction
- Autism Spectrum Disorder Research
- Multiple Sclerosis Research Studies
- Alzheimer's disease research and treatments
- Genetics and Neurodevelopmental Disorders
- Parkinson's Disease Mechanisms and Treatments
- Reproductive System and Pregnancy
- Vitamin D Research Studies
- T-cell and B-cell Immunology
- Neuroinflammation and Neurodegeneration Mechanisms
- Cellular transport and secretion
- COVID-19 and Mental Health
- Polyomavirus and related diseases
- Tryptophan and brain disorders
- Immunotherapy and Immune Responses
- Extracellular vesicles in disease
- Long-Term Effects of COVID-19
- Virology and Viral Diseases
- Diabetes and associated disorders
- Endoplasmic Reticulum Stress and Disease
- Psoriasis: Treatment and Pathogenesis
- Lymphoma Diagnosis and Treatment
- Adenosine and Purinergic Signaling
- Viral-associated cancers and disorders
- RNA regulation and disease
Don Carlo Gnocchi Foundation
2015-2024
University of Milan
2021
Istituti di Ricovero e Cura a Carattere Scientifico
2009-2011
Blood-based biomarkers are needed to be used as easy, reproducible, and non-invasive tools for the diagnosis prognosis of chronic neurodegenerative disorders including Parkinson's Disease (PD). In PD, aggregated toxic forms α-Synuclein (α-Syn) accumulate within neurons in brain cause neurodegeneration; α-Syn interaction with SNARE proteins also results synaptic disfunction. We isolated neural derived extravesicles (NDEs) from peripheral blood 32 PD patients 40 healthy controls (HC) measured...
Approximately 15% of multiple sclerosis (MS) patients develop a progressive form disease from onset; this condition (primary progressive-PP) MS is difficult to diagnose and treat, associated with poor prognosis. Extracellular vesicles (EVs) brain origin isolated blood their protein cargoes could function as biomarker pathological conditions. We verified whether MBP MOG content in oligodendrocytes-derived EVs (ODEVs) be biomarkers help the differential diagnosis clinical phenotypes. A total...
The early differential diagnosis of Parkinson's disease (PD) and atypical Parkinsonian syndromes (APS), including corticobasal degeneration (CBD) progressive supranuclear palsy (PSP), is challenging because an overlap clinical features the lack reliable biomarkers. Neural-derived extracellular vesicles (NDEVs) isolated from blood provide a window into brain's biochemistry may assist in distinguishing between PD APS. We verified case-control study whether oligomeric α-Synuclein Tau aggregates...
The etiopathology of multiple sclerosis (MS) is believed to include genetic and environmental factors. Human leukocyte antigen (HLA) alleles, in particular, are associated with disease susceptibility, whereas Epstein Barr Virus (EBV) infection has long been suspected play a role pathogenesis. aim the present study evaluate correlations between HLA alleles EBV MS. viral load (VL) serum anti-EBV antibody titers were evaluated EBV-seropositive MS patients (N = 117) age- sex-matched healthy...
Abstract MiR-223-3p is involved in the regulation of a broad range cellular processes and many types pathological as cancer, autoimmune inflammatory diseases. has been indicated negative regulator NLRP3 protein, key protein inflammasome. The chronic inflammasome activation, an underlying feature neurodegenerative disorders, induced by misfolded aggregates, including amyloid-beta alpha-synuclein, resulting pro-inflammatory cytokines secretion propagating neuroinflammation. aim study was to...
Alzheimer's disease (AD) is a multifactorial with still barely understood etiology. Herpes simplex virus 1 (HSV-1) has long been suspected to play role in the pathogenesis of AD because its neurotropism, high rate infection general population, and life-long persistence neuronal cells, particularly same brain regions that are usually altered AD. The goal this study was evaluate HSV-1-specific humoral immune responses patients diagnosis either or amnestic mild cognitive impairment (aMCI),...
REM sleep behavior disorder (RBD) has a tighter link with synucleinopathies than other neurodegenerative disorders. Parkinson's Disease (PD) patients RBD have more severe motor and cognitive impairment; biomarkers for are currently unavailable. Synaptic accumulation of α-Syn oligomers their interaction SNARE proteins is responsible synaptic dysfunction in PD. We verified whether oligomeric components neural-derived extracellular vesicles (NDEVs) serum could be RBD. Forty-seven PD were...
The activation of natural killer (NK) cells is modulated by surface molecules. We analyzed NK in human immunodeficiency virus (HIV)-exposed seronegative (HESN) individuals means molecular typing HLA B, Cw, and cell immunoglobulin-like receptor (KIR) In HESN individuals, compared with HIV patients, the frequency inhibitory KIR3DL1 allele KIR3DL1(+)/Bw4(+) complex was reduced, whereas that activatory KIR3DS1(+) ligand Bw4(+)/3DL1(-)/3DS1(+) increased, resulting a statistically significant...
Herpes simplex virus type 1 (HSV-1) has long been suspected to play a role in Alzheimer's disease (AD), the most common form of dementia. IFN-lambda (IFN-λ) is one key cytokine innate antiviral defenses and, particular, an appreciable activity against HSV-1 infection. IFN -λ expression regulated by interaction between two different proteins: Mediator Complex 23 (MED23) and Interferon-Responsive Transcription Factor 7 (IRF7); single nucleotide polymorphisms (SNPs) these genes as well IFNL3...
Vitamin D is endowed with a number of biological properties, including down-regulation inflammation, and might contribute to the pathogenesis autism spectrum disorders (ASD). binds vitamin Receptor (VDR); activity ensuing complex depends on VDR FokI, BsmI, ApaI, TaqI gene polymorphisms. We evaluated such Single Nucletoide Polymorphismsm (SNPs) in cohort 100 Italian families ASD children. FokI genotype distribution was skewed children compared their healthy sibs (Pc = 0.03 2 df) group 170...
Activation of the purinergic receptor P2X7 (P2X7R) is believed to be deleterious in autoimmune diseases and it was hypothesized play a role pathogenesis MS. P2X7R an ATP-gated non-selective cationic channel; its activation can driven by high concentrations ATP leads generation large, cytolytic conductance pores. also result apoptosis as consequence caspase cascade via P2X7R-dependent stimulation NLRP3 inflammasome. We measured oligodendrocyte derived extracellular vesicles (ODEVs) MS...
Synaptosomal-associated protein of 25 kDa (SNAP-25) is an age-regulated vesicular SNARE involved in the exocytosis neurotransmitters from synapses, a process that altered Alzheimer's disease (AD). Changes SNAP-25 levels are sugges
Better knowledge about the possible role of genetic factors in modulating response to multiple sclerosis (MS) treatment, including rehabilitation, known promote neural plasticity, could improve standard care for this disease. Vitamin D receptor (VDR) gene polymorphisms are associated with MS risk, probably because played by vitamin regulating inflammatory and reparative processes. The aim study was evaluate association most important functional VDR SNPs (TaqI (T/C), ApaI (A/C), FokI (C/T))...
Abstract Background Classic Kaposi's Sarcoma (cKS) is a rare vascular tumor associated with Human Herpesvirus 8 (KSHV) infection, nevertheless not all KSHV-infected individuals have cKS. Objective We investigated whether particular KIR/HLA receptor/ligand genotypes would be preferentially present in and uninfected who or developed Methods were analyzed by molecular genotyping 50 did cKS 33 age-and sex-matched KSHV seronegative individuals. Results There was no association of individual KIR,...
Multiple sclerosis (MS) is a chronic autoimmune inflammatory disease of the central nervous system (CNS) that leads to progressive physical disability. Recent evidence has suggested P2X7 receptor (P2X7R)-mediated purinergic signalling pathways play role in MS-associated neuroinflammation, possibly contributing pathogenesis. To evaluate possible associations between P2X7R polymorphisms and MS severity, we performed an association study five non-synonymous SNPs coding variants gene: rs1718119...
A possible role of Snap25 polymorphisms in type 2 diabetes mellitus (T2DM) was evaluated by analyzing three SNPs within intron 1 a region known to affect the gene expression vitro. Genomic DNA from 1019 Saudi individuals (489 confirmed T2DM and 530 controls) genotyped for rs363039, rs363043, rs363050 using TaqMan Genotyping Assay. Significantly higher levels fasting glucose HbA1c were detected patients carrying (AG/GG) genotypes compared (AA) genotype (f = 4.41, df 1, p 0.03 f 5.31, 0.03,...
Alzheimer's disease (AD) is a highly prevalent neurodegenerative disorder. Rate of decline and functional restoration in AD greatly depend on the capacity for neural plasticity within residual tissues; this at least partially influenced by polymorphisms genes that determine plasticity, including Apolipoprotein E4 (ApoE4) synaptosomal-associated protein 25 kDa (SNAP-25).We investigated whether correlations could be detected between ApoE4 SNAP-25 outcome multidimensional rehabilitative...
HLA allelic distribution was analysed in a cohort of 96 Northern Italian subjects (53M/43F) (mean age 59.9 ± 13.3 years) from Lombardy who developed COVID-19 during the first two pandemic waves to investigate possible correlations between molecules and disease severity. An important role HLA- B HLA-C loci modulating clinical severity identified. In particular, HLA-B07 supertype observed be associated with significant risk for severe disease; conversely, HLA-B27 C*12:02 allele played...