A5023815232- Polyomavirus and related diseases
- Multiple Sclerosis Research Studies
- Viral-associated cancers and disorders
- Tryptophan and brain disorders
- Alzheimer's disease research and treatments
- Herpesvirus Infections and Treatments
- Cytomegalovirus and herpesvirus research
- MicroRNA in disease regulation
- Full-Duplex Wireless Communications
- T-cell and Retrovirus Studies
- Lymphoma Diagnosis and Treatment
- Viral Infections and Immunology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Antenna Design and Analysis
- Nuclear Receptors and Signaling
- Parvovirus B19 Infection Studies
- Plant Virus Research Studies
- RNA regulation and disease
- Systemic Lupus Erythematosus Research
- Histiocytic Disorders and Treatments
- Immune Cell Function and Interaction
- HIV Research and Treatment
- RNA Interference and Gene Delivery
- CNS Lymphoma Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
Don Carlo Gnocchi Foundation
2015-2024
University of Catania
2023
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2018-2020
University of Milano-Bicocca
2020
Regis University
2020
University of Colorado Colorado Springs
2019
University of Palermo
2010
Istituti di Ricovero e Cura a Carattere Scientifico
1995-2009
Occidental College
2005
University of Milan
2001
Interleukin-1 beta (IL-1β) and its key regulator, the inflammasome, are suspected to play a role in neuroinflammation observed Alzheimer's disease (AD); no conclusive data nevertheless available AD patients. mRNA for inflammasome components (NLRP1, NLRP3, PYCARD, caspase 1, 5 8) downstream effectors (IL-1β, IL-18) was up-regulated severe MILD AD. Monocytes co-expressing NLRP3 with 1 or 8 were significantly increased alone, whereas those NLRP1 PYCARD augmented both Activation of inflammasomes...
The envelope protein from multiple sclerosis (MS) associated retroviral element (MSRV), a member of the Human Endogenous Retroviral family 'W' (HERV-W), induces dysimmunity and inflammation.The objective this study was to confirm specify association between HERV-W/MSRV (Env) expression MS.103 MS, 199 healthy controls (HC) with other neurological diseases (28), chronic infections (30) or autoimmunity were analysed an immunoassay detecting Env in serum. RNA DNA copy numbers peripheral blood...
Background Interferon gamma (IFN-γ) production induces the transcription of indoleamine 2,3 dioxygenase (IDO) resulting in reduction T-cell activation and proliferation through depletion tryptophan elicitation Treg lymphocytes. IDO was shown to be involved pathogenesis autoimmune diseases; we investigated whether changes gene expression activity could indicative onset relapse multiple sclerosis (MS) patients. Methods interferon-γ expression, serum (Kynurenine/Tryptophan ratio) neopterin...
HSV-1 infection of the central nervous system targets same brain regions most affected in Alzheimer's disease (AD) and could play a pathogenic role AD. serum IgG titers were analyzed patients with mild AD (n = 83) healthy controls (HC, n 51); results correlated cortical grey matter (GM) volumes as by MRI. Seroprevalence antibody (Ab) comparable between HC; elevated Ab (>75th percentile) nevertheless significantly more frequent positively bilateral temporal orbitofrontal GM volumes....
The etiology of Parkinson’s disease (PD) is poorly understood, and strongly suspected to include both genetic environmental factors. In this context, it essential investigate possible biomarkers for prognostic diagnostic purposes. Several studies reported dysregulated microRNA expression in neurodegenerative disorders, including PD. Using ddPCR, we investigated the concentrations miR-7-1-5p, miR-499-3p, miR-223-3p miR-223-5p—miRNAs involved α-synuclein pathway inflammation—in serum...
Abstract Background The incidence of Alzheimer's disease (AD)—the most frequent cause dementia—is expected to increase as life expectancies rise across the globe. While sex-based differences in AD have previously been described, there remain uncertainties regarding any association between sex and disease-associated molecular mechanisms. Studying sex-specific expression profiles regulatory factors such microRNAs (miRNAs) could contribute more accurate diagnosis treatment. Methods A systematic...
The persistently higher rates of adverse birth outcomes among African American women are a major public health concern.The purpose this study was to explore the relations psychosocial stress, socioeconomic status, and in women.A prospective survey research design used measure stress exposure, subjective responses stressors, including intrusive effects life events, medical sociodemographic variables sample 178 pregnant women. Birth were obtained from charts.Life event exposure high, but...
Retrospective studies show that natalizumab modifies oligoclonal immunoglobulin (IgG) bands (OCBs) in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients. In this study, we prospectively analyzed both serum and CSF samples from 24 MS patients, before after 2 years natalizumab-based therapy. Our results showed complete (55%) or partial (27%) disappearance OCBs were taken Intrathecal IgG production, represented by index Loc , was also quantitatively reduced. data substantially...
The etiopathology of multiple sclerosis (MS) is believed to include genetic and environmental factors. Human leukocyte antigen (HLA) alleles, in particular, are associated with disease susceptibility, whereas Epstein Barr Virus (EBV) infection has long been suspected play a role pathogenesis. aim the present study evaluate correlations between HLA alleles EBV MS. viral load (VL) serum anti-EBV antibody titers were evaluated EBV-seropositive MS patients (N = 117) age- sex-matched healthy...
Abstract MiR-223-3p is involved in the regulation of a broad range cellular processes and many types pathological as cancer, autoimmune inflammatory diseases. has been indicated negative regulator NLRP3 protein, key protein inflammasome. The chronic inflammasome activation, an underlying feature neurodegenerative disorders, induced by misfolded aggregates, including amyloid-beta alpha-synuclein, resulting pro-inflammatory cytokines secretion propagating neuroinflammation. aim study was to...
Demyelination and failure of remyelination are core mechanisms in the pathogenesis multiple sclerosis (MS); factor(s) modulating these processes still mostly unknown. MicroRNA 572 (miR-572) is deregulated MS suggested to targets neural cell adhesion molecule (NCAM), a glycoprotein involved CNS reparative mechanisms. The aim this study analyze miR-572 patients with different clinical phenotypes MS.qPCR quantification isolated from serum was performed 16 primary progressive (PP), 15 secondary...
Abstract The link between human herpesvirus 8 (KSHV) and Kaposi's sarcoma (KS) has been proven, but many important aspects including risk factors, genetic predisposition to tumor development, transmission of KSHV, the pathogenic potential different genotypes remain be elucidated. Possible associations clinical parameters antibody levels, viral load fluctuations, genotype were analyzed by quantitative real‐time PCR, an in‐house developed IFA assay, sequence analysis ORF K1‐VR1 in blood, serum...
Alzheimer's disease (AD) is a multifactorial with still barely understood etiology. Herpes simplex virus 1 (HSV-1) has long been suspected to play role in the pathogenesis of AD because its neurotropism, high rate infection general population, and life-long persistence neuronal cells, particularly same brain regions that are usually altered AD. The goal this study was evaluate HSV-1-specific humoral immune responses patients diagnosis either or amnestic mild cognitive impairment (aMCI),...
Abstract In order to investigate the possible involvement of viruses in Multiple Sclerosis (MS), study evaluated presence viral genomic sequences cerebrospinal fluid (CSF), as markers replication within central nervous system (CNS). A total 85 CSF samples were collected from 38 MS patients, 28 patients with other neurological diseases and 19 subjects without diseases. Using nested‐PCR, investigation focused on human herpes virus DNA, including simplex 1 (HSV‐1) 2 (HSV‐2), Epstein‐Barr (EBV),...
Abstract Human polyomavirus JC (JCV) infects the worldwide population, remains latent in kidney, and is excreted urine. A longitudinal study was performed order to evaluate JCV excretion, characterize molecularly virus determine if its presence urine a consequence of viral reactivation or merely epithelial squamous cell shedding. The cellular sediment genome were examined 333 samples collected periodically for 3 months from 17 healthy subjects; molecular characterization, quantitation also...
Abstract The role of viruses in the pathogenesis multiple sclerosis (MS) is a subject heated debate. presence six different neurotropic was sought, including JC virus (JCV), varicella zoster (VZV), human herpesvirus 6 (HHV‐6), and Epstein‐Barr (EBV), cerebrospinal fluid (CSF) samples collected from 51 patients with MS 30 other neurological diseases. Cell‐free or cell‐associated viral DNA CSF detected by real‐time PCR, loads were determined. Magnetic resonance imaging (MRI) examinations also...
Background: Alzheimer’s disease (AD), the most common form of dementia worldwide, is associated with impairment in mechanisms clearing amyloid-β within a scenario neuroinflammation. The etiopathogenesis AD unclear, but role for viral infection suspected to play initiating disease. We recently described positive correlation between high titers HSV-1-specific antibodies (Ab) and volumes brain regions typically affected Objective: exploration possible Herpesviridae was extended by analyzing...